Graded
Ministerstwo zdrowia USA opublikowało projekt zasad, według którego nie będzie ścigać aptek przygotowujących BPC-157 na receptę dla konkretnej osoby, dopóki FDA nie zdecyduje w przepisach. To nadal nie jest dopuszczony lek.
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SS-31

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Prace naukowe

BadaniaRodzaj badaniaRok
Effect of mitochondrial-targeted antioxidants on glycaemic control, cardiovascular health, and oxidative stress in humans: A systematic review and meta-analysis of randomized controlled trials.Diabetes Obes MetabAnaliza zbiorcza2022
Initial Psychometric Evaluation of the Barth Syndrome Symptom Assessment (BTHS-SA) for Adolescents and Adults in a Phase 2 Clinical Study.Orphanet J Rare DisZ losowaniem grup2025
Genotype-specific effects of elamipretide in patients with primary mitochondrial myopathy: a post hoc analysis of the MMPOWER-3 trial.Orphanet J Rare DisZ losowaniem grup2024
Effect of Aficamten on Health Status Outcomes in Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA-HCM.J Am Coll CardiolZ losowaniem grup2024
Elamipretide Topical Ophthalmic Solution for the Treatment of Subjects with Leber Hereditary Optic Neuropathy: A Randomized Trial.OphthalmologyZ losowaniem grup2024
Identifying responders to elamipretide in Barth syndrome: Hierarchical clustering for time series data.Orphanet J Rare DisZ losowaniem grup2023
In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial.PLoS OneZ losowaniem grup2021
A phase 2/3 randomized clinical trial followed by an open-label extension to evaluate the effectiveness of elamipretide in Barth syndrome, a genetic disorder of mitochondrial cardiolipin metabolism.Genet MedZ losowaniem grup2021
Effects of Elamipretide on Left Ventricular Function in Patients With Heart Failure With Reduced Ejection Fraction: The PROGRESS-HF Phase 2 Trial.J Card FailZ losowaniem grup2020
The mitochondria-targeting peptide elamipretide diminishes circulating HtrA2 in ST-segment elevation myocardial infarction.Eur Heart J Acute Cardiovasc CareZ losowaniem grup2019
Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide.Circ Heart FailZ losowaniem grup2017
Phase 2a Clinical Trial of Mitochondrial Protection (Elamipretide) During Stent Revascularization in Patients With Atherosclerotic Renal Artery Stenosis.Circ Cardiovasc IntervZ losowaniem grup2017
Relation of Left Ventricular Mass and Infarct Size in Anterior Wall ST-Segment Elevation Acute Myocardial Infarction (from the EMBRACE STEMI Clinical Trial).Am J CardiolZ losowaniem grup2016
Effects of Single Vs. Multiple Sets during 10 Weeks of Water-based Resistance Training on Neuromuscular Adaptations in Young Women.Int J Sports MedZ losowaniem grup2016
EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention.Eur Heart JZ losowaniem grup2016
Comparison of the pharmacokinetics of a new 30 mg modified-release tablet formulation of metoclopramide for once-a-day administration versus 10 mg immediate-release tablets: a single and multiple-dose, randomized, open-label, parallel study in healthy male subjects.Eur J Drug Metab PharmacokinetZ losowaniem grup2012
Natural history comparison study to assess the efficacy of elamipretide in patients with Barth syndrome.Orphanet J Rare DisBez losowania grup2022
Antibodies to pancreatic duct cells in Sjögren's syndrome and rheumatoid arthritis.GutBez losowania grup1977
RePOWER: An International, Prospective, Non-Interventional Registry of Patients With Primary Mitochondrial Myopathy.Clin GenetObserwacja grupy2026
Elamipretide in pediatric Barth syndrome: from heart failure to school return.Orphanet J Rare DisOpisy przypadków2026
Cardiac pathology in a patient with a novel pathogenic variant c.703del (p.Ile235SerfsTer4) of the TAFAZZIN gene.Cardiovasc PatholOpisy przypadków2025
Elamipretide in the Management of Barth Syndrome: Current Evidence and a Case Report.Mol Genet MetabOpisy przypadków2025
Expanded-access use of elamipretide in a newborn with Barth syndrome: a case report.Eur Heart J Case RepOpisy przypadków2025
Expanded-access use of elamipretide in a patient with membrane protein-associated neurodegeneration.Clin Case RepOpisy przypadków2024
Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes.Adv Sci (Weinh)Przegląd badań2026
Mitochondrial Quality Control in Inherited Mitochondrial Cardiomyopathy: Convergent Pathobiology and a Testable Therapeutic Framework.Int J Mol SciPrzegląd badań2026
The Oxidative-Mitochondrial-Inflammatory Axis in Retinitis Pigmentosa: Extracellular mtDNA as Biomarker and Therapeutic Read-Out.Antioxidants (Basel)Przegląd badań2026
Microvascular dysfunction and neurovascular signalling impairment in diabetic silent myocardial ischemia.Microvasc ResPrzegląd badań2026
Redox imbalance and mitochondrial dysfunction in gestational diabetes mellitus: Implications for maternal health, placental function, and offspring metabolic programming.Free Radic Biol MedPrzegląd badań2026
Reactive oxygen species and antioxidant strategies in human sperm cryodamage.Front Med (Lausanne)Przegląd badań2026
Targeting Mitochondria for Postoperative Cognitive Dysfunction: From Mechanisms to Therapeutics.Mol NeurobiolPrzegląd badań2026
Clinical development in primary mitochondrial diseases at a translational inflection point: Lessons, mechanisms, and emerging therapeutic strategies.Biomed PharmacotherPrzegląd badań2026
The Role of Oxidative Stress in Heart Failure: Mechanisms and Therapeutic Targets.CureusPrzegląd badań2026
Therapeutic targeting of mitochondrial dysfunction in heart failure: a systematic review & meta-analysis of clinical outcomes.Front Cardiovasc MedPrzegląd badań2026
Drug repurposing in Alzheimer's disease: Emerging therapeutic strategies and promising candidates.Ageing Res RevPrzegląd badań2026
Cardiolipin remodelling in mitochondrial therapeutics: translational evidence chains from elamipretide to emerging strategies.Front PhysiolPrzegląd badań2026
Mitochondrial Dysfunction at the Intersection of CKM Syndrome: Molecular Mechanisms and Path-to-Target Therapies.Int J Mol SciPrzegląd badań2026
Effect of mitochondrial dysfunction on scar formation after spinal cord injury.Front NeurolPrzegląd badań2026
Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives.Int J Mol SciPrzegląd badań2026
Mitochondrial dysfunction-driven inflammation and β-Cell apoptosis in type 2 diabetes mellitus: mechanistic insights and therapeutic implications.Mol Biol RepPrzegląd badań2026
Mitochondrial dysfunction, neuroinflammation, and associated mechanisms in sepsis-associated encephalopathy: from pathogenesis to emerging therapeutics.Front NeurosciPrzegląd badań2026
Mitochondrial Calcium Dysregulation and Targeted Therapies in Heart Failure.Rev Cardiovasc MedPrzegląd badań2026
Paradigm shift: from pulmonary vasodilation to cardiopulmonary dual-track therapy-a comprehensive review of pathophysiology and advances in pulmonary hypertension-associated right heart failure.Respir ResPrzegląd badań2026
Elamipretide: First Approval.DrugsPrzegląd badań2026
Mitochondria at the Crossroads of Cardiovascular Disease: Mechanistic Drivers and Emerging Therapeutic Strategies.CellsPrzegląd badań2026
2025 FDA TIDES (Peptides and Oligonucleotides) Harvest.Pharmaceuticals (Basel)Przegląd badań2026
New Insights on Mitochondria-Targeted Neurological Drugs.Biology (Basel)Przegląd badań2026
Mitochondrial Metabolic Checkpoints in Human Fertility: Reactive Oxygen Species as Gatekeepers of Gamete Competence.CellsPrzegląd badań2026
Mitochondrial Dysfunction: The Cellular Bridge from Emotional Stress to Disease Onset: A Narrative Review.BiomoleculesPrzegląd badań2026
Therapeutic Approaches Involving Mitochondria in the Treatment of Acute Kidney Injury.Semin NephrolPrzegląd badań2026
Targeted nanoliposomal nutrient delivery for human health.World J Gastrointest Pharmacol TherPrzegląd badań2025
Role of Peptides in Skeletal Muscle Wasting: A Scoping Review.J Cachexia Sarcopenia MusclePrzegląd badań2025
Mitochondrial dysfunction, reactive oxygen species, and diabetes mellitus - A triangular relationship: A review.Biomol BiomedPrzegląd badań2025
Role of the mitochondrial regulatory factor CHCHD2 in neurodegenerative diseases.Front NeurosciPrzegląd badań2025
The Redox Revolution in Brain Medicine: Targeting Oxidative Stress with AI, Multi-Omics and Mitochondrial Therapies for the Precision Eradication of Neurodegeneration.Int J Mol SciPrzegląd badań2025
Dry Eye Disease: Oxidative Stress on Ocular Surface and Cutting-Edge Antioxidants.Glob ChallPrzegląd badań2025
Advances in Management of Mitochondrial Myopathies.Int J Mol SciPrzegląd badań2025
Beyond the injection: delivery systems reshaping retinal disease management.Expert Opin PharmacotherPrzegląd badań2025
Contemporary insights into elamipretide's mitochondrial mechanism of action and therapeutic effects.Biomed PharmacotherPrzegląd badań2025
The Potential of Mitochondrial Therapeutics in the Treatment of Oxidative Stress and Inflammation in Aging.Mol NeurobiolPrzegląd badań2025
Mitochondrial Dysfunction: The Silent Catalyst of Kidney Disease Progression.CellsPrzegląd badań2025
Targeting the Electron Transport System for Enhanced Longevity.BiomoleculesPrzegląd badań2025
The Application and Molecular Mechanisms of Mitochondria-Targeted Antioxidants in Chemotherapy-Induced Cardiac Injury.Curr Issues Mol BiolPrzegląd badań2025
Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential.Int J Mol SciPrzegląd badań2025
Innovative technologies for the treatment of dry age-related macular degeneration (AMD) - modern therapeutic perspectives and their future.Rom J OphthalmolPrzegląd badań2025
Podocyte senescence: from molecular mechanisms to therapeutics.Ren FailPrzegląd badań2024
Nanozymes targeting mitochondrial repair in disease treatment.J BiotechnolPrzegląd badań2024
The bioenergetics of traumatic brain injury and its long-term impact for brain plasticity and function.Pharmacol ResPrzegląd badań2024
Cardiomyopathy in Duchenne Muscular Dystrophy and the Potential for Mitochondrial Therapeutics to Improve Treatment Response.CellsPrzegląd badań2024
Challenging and target-based shifting strategies for heart failure treatment: An update from the last decades.Biochem PharmacolPrzegląd badań2024
Mitochondrial disorders leading to Alzheimer's disease-perspectives of diagnosis and treatment.GerosciencePrzegląd badań2024
Genetic Mutations and Mitochondrial Redox Signaling as Modulating Factors in Hypertrophic Cardiomyopathy: A Scoping Review.Int J Mol SciPrzegląd badań2024
Mitofilin in cardiovascular diseases: Insights into the pathogenesis and potential pharmacological interventions.Pharmacol ResPrzegląd badań2024
Application research of novel peptide mitochondrial-targeted antioxidant SS-31 in mitigating mitochondrial dysfunction.MitochondrionPrzegląd badań2024
Biomaterials Functionalized with Inflammasome Inhibitors-Premises and Perspectives.J Funct BiomaterPrzegląd badań2024
The emerging significance of mitochondrial targeted strategies in NAFLD treatment.Life SciPrzegląd badań2023
Temporal evolution of the heart failure phenotype in Barth syndrome and treatment with elamipretide.Future CardiolPrzegląd badań2023
Skeletal muscle mitochondrial remodeling in heart failure: An update on mechanisms and therapeutic opportunities.Biomed PharmacotherPrzegląd badań2022
Targeting mitochondrial dysfunction with elamipretide.Heart Fail RevPrzegląd badań2022
Elamipretide for Barth syndrome cardiomyopathy: gradual rebuilding of a failed power grid.Heart Fail RevPrzegląd badań2022
Current and emerging drug targets in heart failure treatment.Heart Fail RevPrzegląd badań2022
SS-31, a Mitochondria-Targeting Peptide, Ameliorates Kidney Disease.Oxid Med Cell LongevPrzegląd badań2022
Mitochondria as Therapeutic Targets in Heart Failure.Curr Heart Fail RepPrzegląd badań2022
Role of Mitochondrial Therapy for Ischemic-Reperfusion Injury and Acute Kidney Injury.NephronPrzegląd badań2022
Current and future treatment approaches for Barth syndrome.J Inherit Metab DisPrzegląd badań2022
Neuroprotective Effects of a Small Mitochondrially-Targeted Tetrapeptide Elamipretide in Neurodegeneration.Front Integr NeurosciPrzegląd badań2021
Pharmacologic approaches to prevent skeletal muscle atrophy after spinal cord injury.Curr Opin PharmacolPrzegląd badań2021
Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD).CellsPrzegląd badań2021
Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer's disease.Pharmacol ResPrzegląd badań2021
Barth syndrome cardiomyopathy: targeting the mitochondria with elamipretide.Heart Fail RevPrzegląd badań2021
Emerging Therapies in Nonexudative Age-Related Macular Degeneration in 2020.Asia Pac J Ophthalmol (Phila)Przegląd badań2021
Treatment of Leber's hereditary optic neuropathy: An overview of recent developments.Eur J OphthalmolPrzegląd badań2020
Mitochondrial targeted therapy with elamipretide (MTP-131) as an adjunct to tumor necrosis factor inhibition for traumatic optic neuropathy in the acute setting.Exp Eye ResPrzegląd badań2020
Targeting reactive oxygen species (ROS) to combat the age-related loss of muscle mass and function.BiogerontologyPrzegląd badań2020
Oxidative stress and inflammation in the evolution of heart failure: From pathophysiology to therapeutic strategies.Eur J Prev CardiolPrzegląd badań2020
Advances in primary mitochondrial myopathies.Curr Opin NeurolPrzegląd badań2019
Cardiolipin-targeted peptides rejuvenate mitochondrial function, remodel mitochondria, and promote tissue regeneration during aging.Arch Biochem BiophysPrzegląd badań2018
Mitochondrial bioenergetics, redox state, dynamics and turnover alterations in renal mass reduction models of chronic kidney diseases and their possible implications in the progression of this illness.Pharmacol ResPrzegląd badań2018
Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review.Antioxidants (Basel)Przegląd badań2018
Myocardial Energetics and Heart Failure: a Review of Recent Therapeutic Trials.Curr Heart Fail RepPrzegląd badań2018
Stealth Peptides Target Cellular Powerhouses to Fight Rare and Common Age-Related Diseases.Protein Pept LettPrzegląd badań2018
Mitochondrial genetics and therapeutic overview of Leber's hereditary optic neuropathy.Indian J OphthalmolPrzegląd badań2017
Therapies for mitochondrial diseases and current clinical trials.Mol Genet MetabPrzegląd badań2017
Targeting mitochondrial function to treat optic neuropathy.MitochondrionPrzegląd badań2017
Targeting Mitochondrial Calcium Handling and Reactive Oxygen Species in Heart Failure.Curr Heart Fail RepPrzegląd badań2017
Targeting Metabolic Modulation and Mitochondrial Dysfunction in the Treatment of Heart Failure.DiseasesPrzegląd badań2017
Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury.Oxid Med Cell LongevPrzegląd badań2016
Serendipity and the discovery of novel compounds that restore mitochondrial plasticity.Clin Pharmacol TherPrzegląd badań2014
Mitochondria-targeted agents: Future perspectives of mitochondrial pharmaceutics in cardiovascular diseases.World J CardiolPrzegląd badań2014
Mitochondria-targeted therapies for acute kidney injury.Expert Rev Mol MedPrzegląd badań2014
Mechanisms of skeletal muscle ageing; avenues for therapeutic intervention.Curr Opin PharmacolPrzegląd badań2014
Mitochondrial oxidative stress in aging and healthspan.Longev HealthspanPrzegląd badań2014
First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics.Br J PharmacolPrzegląd badań2014
Is further improvement of the treatment of acute coronary syndromes still possible?Postepy Kardiol InterwencyjnejPrzegląd badań2013
Mitochondrial approaches for neuroprotection.Ann N Y Acad SciPrzegląd badań2008
[Therapeutic options for patients with localized prostatic carcinoma: our experience with 454 patients].Actas Urol EspPrzegląd badań2004
Seawater immersion reshapes the temporal dynamics of traumatic brain injury and reveals mitochondrial oxidative stress as a modifiable therapeutic target.Exp NeurolNa zwierzętach2026
Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats.Brain Behav ImmunNa zwierzętach2026
Oral Colon- and Mitochondria-Targeted Nanoparticles Alleviate Ulcerative Colitis by Reeducating Macrophage Polarization via SIRT3/FOXO3a-Mediated Mitochondrial Restoration.J Gastroenterol HepatolNa zwierzętach2026
Targeting Mitochondria in MASLD: Comparative Evaluation of MitoQ and SS-31 (Elamipretide) in Aged Female Mice under Nutritional Stress.Physiol ResNa zwierzętach2026
Targeting Mitochondrial Dysfunction With Elamipretide (SS-31) Improves Skeletal Muscle Performance in a HFpEF Rat Model.Circ Heart FailNa zwierzętach2026
Breaking a mitochondrial danger-STING feed-forward amplifier preserves alveolar-capillary architecture and dampens interferon-chemokine signaling in acute lung injury.Tissue CellNa zwierzętach2026
Mitochondrial dysfunction drives age-related degeneration of the thoracic aorta.GeroscienceNa zwierzętach2026
Elamipretide (SS-31) and Nicotinamide Mononucleotide (NMN) Combination Therapy Targets TREM2 to Mitigate Post-ischemic Brain Injury in Mice.Neurochem ResNa zwierzętach2026
Topology-Controlled PEGylation Enhances Renal Accumulation of Therapeutic Peptide for Treating Ischemia-Reperfusion Injury.Nano LettNa zwierzętach2026
Elamipretide (SS-31) promotes recovery by preserving mitochondrial bioenergetics and neural remodeling after spinal cord injury.Neurochem IntNa zwierzętach2026
Peroxiredoxin Ⅲ safeguards cardiac function against doxorubicin by regulating mitochondrial quality control via H2O2 detoxification.Redox BiolNa zwierzętach2026
Mitochondria-Targeted Liposomes Boost Thermogenesis for Adipose Tissue Regulation.Adv Healthc MaterNa zwierzętach2026
Protective Effect of Mitochondria-Targeted Polydopamine Nanoparticles in Alleviating Hepatic Ischemia-Reperfusion Injury.ACS NanoNa zwierzętach2026
SLC25A28 Ameliorates Hyperoxic Lung Injury by Improving Mitochondrial Oxidative Phosphorylation in Alveolar Epithelial Cells.Int J Mol SciNa zwierzętach2026
Early targets and progressive deterioration in cardiac performance in response to chronically modified cardiac troponin I.Am J Physiol Heart Circ PhysiolNa zwierzętach2026
NNT inhibits microglial activation via mitochondrial oxidative stress in spinal cord injury.Neurosci LettNa zwierzętach2026
SS-31 improves the quality of maternally aged oocytes by ameliorating mitochondrial function and metabolism.J Ovarian ResNa zwierzętach2026
Mitochondrial Targeting by Elamipretide Improves Myocardial Bioenergetics Without Translating into Functional Benefits in HFpEF.Int J Mol SciNa zwierzętach2026
SS-31 improves post-cardiac arrest brain injury by inhibiting microglial ferroptosis and polarization.NeurotherapeuticsNa zwierzętach2026
Targeted Delivery of AGO-2 to Myocardial Mitochondria via Functionalized Nanoparticles Attenuates Oxidative Stress in Diabetic Cardiomyopathy.ACS Appl Mater InterfacesNa zwierzętach2025
Endothelial Glycocalyx Degradation as a Mediator of Neuroinflammation and Cognitive Impairment in Aged Rats: Protective Role of SS-31.Mol NeurobiolNa zwierzętach2025
Environmental enrichment highlights mitochondrial inner membrane function as a therapeutic target for sepsis-associated encephalopathy.Brain ResNa zwierzętach2025
A Polytherapy Intervention in an Experimental Traumatic Optic Neuropathy Mouse Model.Ophthalmic Plast Reconstr SurgNa zwierzętach2025
Elamipretide enhances post-thaw rooster sperm quality by mitigating oxidative stress and optimizing mitochondrial function during cryopreservation.Sci RepNa zwierzętach2025
Acute mitochondrial reactive oxygen species emissions drive mitochondrial dysfunction after traumatic muscle injury in male mice.Am J Physiol Cell PhysiolNa zwierzętach2025
Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high-throughput machine learning-driven imaging pipeline for cerebromicrovascular protection therapeutic screening.GeroscienceNa zwierzętach2025
The Mitochondria-Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age.Aging CellNa zwierzętach2025
The mitochondrial dysfunction regulated by JAK2/STAT3 pathway leads to the necroptosis in the renal cells under patulin exposure.Ecotoxicol Environ SafNa zwierzętach2025
SS-31: A promising therapeutic agent against bleomycin-induced pulmonary fibrosis in Mice.PLoS OneNa zwierzętach2025
Mitochondrial Cardiolipin-Targeted Tetrapeptide, SS-31, Exerts Neuroprotective Effects Within In Vitro and In Vivo Models of Spinal Cord Injury.Int J Mol SciNa zwierzętach2025
Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization.Nat CommunNa zwierzętach2025
Acid-Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function.Adv Healthc MaterNa zwierzętach2025
Effect of elamipretide and methylprednisolone treatment on optic nerve, retina and brain damage in a methanol poisoning model: biochemical and histopathological evaluation.Cutan Ocul ToxicolNa zwierzętach2025
The potential of mitochondrially-targeted tetrapeptide in protecting against noise-induced hearing impairment.NeuroreportNa zwierzętach2025
SS-31@Fer-1 Alleviates ferroptosis in hypoxia/reoxygenation cardiomyocytes via mitochondrial targeting.Biomed PharmacotherNa zwierzętach2025
The Mitochondria-Targeted Micelle Inhibits Alzheimer's Disease Progression by Alleviating Neuronal Mitochondrial Dysfunction and Neuroinflammation.SmallNa zwierzętach2025
Synergistic effects of PS-NPs and Cd on ovarian toxicity in adolescent rats: Ferroptosis by induction of mitochondrial redox imbalance via the SIRT3-SOD2/Gpx4 pathway.Ecotoxicol Environ SafNa zwierzętach2025
Low expression of Frataxin might contribute to diabetic peripheral neuropathy in a mouse model.Biochem Biophys Res CommunNa zwierzętach2025
Age-related changes of skeletal muscle metabolic response to contraction are also sex-dependent.J PhysiolNa zwierzętach2025
The involvement and possible targeting of cardiolipins degradation and disturbed linoleic acid metabolism in cardiac atrophy under cancer cachexia.Eur J PharmacolNa zwierzętach2024
New insight for SS‑31 in treating diabetic cardiomyopathy: Activation of mitoGPX4 and alleviation of mitochondria‑dependent ferroptosis.Int J Mol MedNa zwierzętach2024
Effect of Elamipretide on the Vitrification of Mouse Ovarian Tissue by Freezing.Biopreserv BiobankNa zwierzętach2024
Post-sepsis chronic muscle weakness can be prevented by pharmacological protection of mitochondria.Mol MedNa zwierzętach2024
Mitochondria-targeting peptide SS-31 attenuates ferroptosis via inhibition of the p38 MAPK signaling pathway in the hippocampus of epileptic rats.Brain ResNa zwierzętach2024
Skeletal muscle mitochondrial dysfunction mediated by Pseudomonas aeruginosa quorum-sensing transcription factor MvfR: reversing effects with anti-MvfR and mitochondrial-targeted compounds.mBioNa zwierzętach2024
SS-31 treatment ameliorates cardiac mitochondrial morphology and defective mitophagy in a murine model of Barth syndrome.Sci RepNa zwierzętach2024
Mitochondrial antioxidant elamipretide improves learning and memory impairment induced by chronic sleep deprivation in mice.Brain BehavNa zwierzętach2024
Hepatocyte mitochondrial DNA mediates macrophage immune response in liver injury induced by trichloroethylene.Ecotoxicol Environ SafNa zwierzętach2024
A free and user-friendly software protocol for the quantification of microfauna swimming behavior.BiotechniquesNa zwierzętach2024
Mitochondria-targeted reactive oxygen species blockor SS-31 blocks hepatic stellate cell activation and alleviates hepatic fibrosis by regulating NLRP3 inflammasomes.Cell Mol Biol (Noisy-le-grand)Na zwierzętach2024
Role of Mitochondrial ROS for Calcium Alternans in Atrial Myocytes.BiomoleculesNa zwierzętach2024
Mitochondrial dysfunction and endoplasmic reticulum stress induced by activation of PPARα leaded testicular to apoptosis in SD rats explored to di-(2-ethylhexyl) phthalate (DEHP).Ecotoxicol Environ SafNa zwierzętach2023
Targeting mitochondria in the aged cerebral vasculature with SS-31, a proteomic study of brain microvessels.GeroscienceNa zwierzętach2023
Synovial fluid mitochondrial DNA concentration reflects the degree of cartilage damage after naturally occurring articular injury.Osteoarthritis CartilageNa zwierzętach2023
Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice.GeroscienceNa zwierzętach2023
SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop.J Headache PainNa zwierzętach2023
Mitochondrial connexin43 and mitochondrial KATP channels modulate triggered arrhythmias in mouse ventricular muscle.Pflugers ArchNa zwierzętach2023
Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock.Sci RepNa zwierzętach2023
The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging.ElifeNa zwierzętach2023
Peptide coacervate-Prussian blue hybrid supraparticle-tailored scaffolds for revitalizing diabetic heart valve regeneration via multiplex oxidative stress regulation.BiomaterialsW probówce2026
Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury.J Mol Cell CardiolW probówce2012
Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells.J Pharmacol Exp TherW probówce2009
Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function.J Am Soc NephrolW probówce2007
Pre-qualifications, learning strategies, and study satisfaction among medical students: insights from a multicenter German study.Med Educ OnlineInna praca2026
Mitochondria-targeted MXene-based nanozymes promote mitophagy and inhibit mtDNA-triggered cGAS/STING inflammation in osteoarthritis.Bioact MaterInna praca2026
Report from the 2026 Barth Syndrome Foundation International Scientific, Medical & Family Conference: Advances in Barth Syndrome Research, Therapy Development, and Clinical Care.J Dev BiolInna praca2026
Mitochondria-targeted peptide elamipretide alleviates cisplatin-induced ovarian failure by activating the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway.Front PharmacolInna praca2026
Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging.Aging CellInna praca2026
Engineered Mitochondria-Targeted Biomimetic Hybrid Nanovesicles Ameliorate Rheumatoid Arthritis via Regulating Macrophage Autophagy and cGAS-STING Signaling.ACS Appl Mater InterfacesInna praca2026
Elamipretide: a mitochondria-targeting drug for Barth syndrome.Trends Pharmacol SciInna praca2026
Mitochondrial-targeted SS-31 peptide attenuates radiation-induced cardiomyocyte senescence.J Radiat ResInna praca2026
AMCP Market Insights: Managed care considerations in Barth syndrome.J Manag Care Spec PharmInna praca2026
Mitochondrial-Targeted SS-31 Attenuates the Doxorubicin-Induced Cardiomyoblast H9C2 Cell Senescence.Biology (Basel)Inna praca2026
Is an emerging pharmacotherapeutic era for rare mitochondrial diseases here?Cell MetabInna praca2026
Therapeutic Peptide SS-31 Modulates Membrane Binding and Aggregation of α-Synuclein and Restores Impaired Mitochondrial Function.Chem Biol Drug DesInna praca2026
Synergistic mitochondrial homeostasis regulation and cholinergic circuits reconstruction via a one-step synthesized multifunctional hydrogel facilitates spinal cord injury repair.Bioact MaterInna praca2026
Patient self-selection does not influence postoperative improvements in pain, function, or satisfaction in ream-and-run arthroplasty patients.J Shoulder Elbow SurgInna praca2026
Restoring cardiolipin homeostasis mitigates cerebral ischemia-reperfusion injury by suppressing ATG5-mediated neuronal autophagy-dependent ferroptosis.J Adv ResInna praca2026
Energy-replenishing, mitochondria-targeted hydrogel microspheres mitigate sarcopenia via cellular senescence amelioration.J Control ReleaseInna praca2026
Mechanisms of Anti-Oxidants, N-Acetylcysteine and Elamipretide (SS-31), on Ozone-Induced Airway Hyperresponsiveness and Mucus Hypersecretion.LungInna praca2026
Mitochondria dysfunction and increased expression of WNT5A and BNIP3 in tenocytes obtained from patients with tendinopathy.JSES IntInna praca2026
Association of hippocampus, entorhinal cortex, and amygdala with thyroid function: a bilateral volumetric analysis.Thyroid ResInna praca2026
Elamipretide Hydrochloride.Am J Health Syst PharmInna praca2026
Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats.bioRxivInna praca2026
Cuproptosis of bronchial epithelial cells triggers airway remodeling in chronic asthma.Sci RepInna praca2026
Elamipretide Improves Mitochondrial Function in Mitochondrial Trifunctional Protein-Deficient Mice and Human Fibroblasts.J Inherit Metab DisInna praca2026
Mitochondria-Targeted Peptides and Bilayer Composition Modulate Membrane Electroporation under Elevated Electrochemical Stress.LangmuirInna praca2025
Real-world disease burden and health care resource utilization for patients with Barth syndrome.J Med EconInna praca2025
SS-31 Targets NOS2 to Enhance Osteogenic Differentiation in Aged BMSCs by Restoring Mitochondrial Function.OrganogenesisInna praca2025
Targeting ANT1 to regulate PINK1/Parkin-mediated mitophagy is an effective treatment of trauma-induced tendon heterotopic ossification.J Orthop TranslatInna praca2025
YTHDF1-mediated mitochondrial dysfunction and allergic airway inflammation by interaction with β-catenin/TCF4 signaling.Int ImmunopharmacolInna praca2025
Sirt6 deficiency exacerbates angiotensin II-induced lipid nephrotoxicity by affecting PLD6-derived cardiolipin metabolism in podocytes.Cell SignalInna praca2025
Deciphering the Effects of Quenching on the Chemodiversity of Low- and Non-volatile Disinfection Byproducts in Drinking Source Water Using ESI(-)-FT-ICR MS.Environ Sci TechnolInna praca2025
Mitochondrial-Targeted Protective Potential of Elamipretide for the In Vitro Production of Porcine Embryos.Animals (Basel)Inna praca2025
Examination of mitochondria- and inflammasome-mediated mechanisms of clozapine-induced myocarditis using patient-derived iPSC cardiomyocytes.Mol PsychiatryInna praca2025
Szeto-Schiller 31 eases acute lung injury in neonatal mice with acute respiratory distress syndrome by mediating TXNIP expression and NLRP3 inflammasome activation.Transl PediatrInna praca2025
The Efficacy and Sustainability of an Implementation Intervention (FOCUS Program) on Linkage to Hepatitis C Care Time at a Community Health Center in the Deep South: A Longitudinal Study Based on Electronic Medical Records.J Viral HepatInna praca2025
[Down-regulation of ACADM-mediated lipotoxicity inhibits invasion and metastasis of estrogen receptor-positive breast cancer cells].Nan Fang Yi Ke Da Xue Xue BaoInna praca2025
Polyphosphate- and Antioxidant Peptide-Based Coacervate Delivers miRNA.ACS Appl Mater InterfacesInna praca2025
Mitochondrial Dysfunction Drives Age-Related Degeneration of the Thoracic Aorta.bioRxivInna praca2025
A multifunctional mitochondria-protective gene delivery platform promote intervertebral disc regeneration.BiomaterialsInna praca2025
What do employers need when supporting stroke survivors to return to work?: a mixed-methods study.Top Stroke RehabilInna praca2025
Enhancing Mitochondrial Function Through Pharmacological Modification: A Novel Approach to Mitochondrial Transplantation in a Sepsis Model.BiomedicinesInna praca2025
Milk-derived exosome-loaded SS31 as a novel strategy to mitigate UV-induced photodamage in skin.J Photochem Photobiol BInna praca2025
Reprogramming of Treg cell-derived small extracellular vesicles effectively prevents intestinal inflammation from PANoptosis by blocking mitochondrial oxidative stress.Trends BiotechnolInna praca2025
Cadmium-cardiolipin disruption of respirasome assembly and redox balance through mitochondrial membrane rigidification.J Lipid ResInna praca2025
ReCLAIM-2: A Randomized Phase II Clinical Trial Evaluating Elamipretide in Age-related Macular Degeneration, Geographic Atrophy Growth, Visual Function, and Ellipsoid Zone Preservation.Ophthalmol SciInna praca2025
Age-related changes of skeletal muscle metabolic response to contraction are also sex-dependent.J PhysiolInna praca2025
Expanded-Access Use of Elamipretide Improves Quality of Life in Patients With Rare Mitochondrial Disorders Characterized by Ophthalmic Symptoms: A Case Series.Clin Case RepInna praca2024
The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age.bioRxivInna praca2024
SS-31 modification alleviates ferroptosis induced by superparamagnetic iron oxide nanoparticles in hypoxia/reoxygenation cardiomyocytes.HeliyonInna praca2024
Scar sarcoidosis: Clinical features and prognostic significance.Sarcoidosis Vasc Diffuse Lung DisInna praca2024
Discovery of novel SS-31 (d-Arg-dimethylTyr-Lys-Phe-NH2) derivatives as potent agents to ameliorate inflammation and increase mitochondrial ATP synthesis.RSC AdvInna praca2024
SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.Chem Biol InteractInna praca2024
Silver nanoparticle-induced cell damage via impaired mtROS-JNK/MnSOD signaling pathway.Toxicol Mech MethodsInna praca2024
Megalin-targeting and ROS-responsive elamipretide-conjugated polymeric prodrug for treatment of acute kidney injury.Biomed PharmacotherInna praca2024
Expanded-access use of elamipretide in a critically ill patient with Barth syndrome.Genet Med OpenInna praca2024
SS-31 inhibits the inflammatory response by increasing ATG5 and promoting autophagy in lipopolysaccharide-stimulated HepG2 cells.Biochem Biophys Res CommunInna praca2024

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Zarejestrowane badania na ludziach (29)

BadaniaEtapStatusLiczba uczestnikówAktualizacja
An Intermediate Size Expanded Access Protocol of Elamipretide–Dostęp poza badaniem–2026-10-27
ReNEW:Phase 3 Study of Efficacy, Safety & Pharmacokinetics of Subcutaneous Injections of Elamipretide in Subjects With Dry Age-Related Macular Degeneration (Dry AMD)Etap 3Trwa, bez nowych osób3132026-09-17
Clinical Trial in Patients With Barth Syndrome- 4TAZPowerEtap 4Szuka uczestników482026-09-17
FRDA Investigator Initiated Study (IIS) With ElamipretideEtap 1, Etap 2Zakończone202025-12-12
Study of Healthy Aging and Physical Function With ElamipretideEtap 2Szuka uczestników302025-12-10
Study to Evaluate Efficacy and Safety of Elamipretide in Subjects With Primary Mitochondrial Disease From Nuclear DNA Mutations (nPMD)Etap 3Zakończone1022025-10-24
ReCLAIM-2 Study to Evaluate Safety,Efficacy & Pharmacokinetics of Elamipretide in Subjects With AMD With Non-central GAEtap 2Zakończone1762024-07-12
A Trial to Evaluate Safety, Tolerability and Efficacy of Elamipretide in Subjects With Barth SyndromeEtap 2, Etap 3Zakończone122024-04-16
A Trial to Evaluate Safety and Efficacy of Elamipretide Primary Mitochondrial Myopathy Followed by Open-Label ExtensionEtap 3Przerwane2182022-01-24
Open-Label Extension Trial to Characterize the Long-term Safety and Tolerability of Elamipretide in Subjects With Genetically Confirmed Primary Mitochondrial Myopathy (PMM)Etap 2Przerwane282021-12-17
A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for Treatment of Leber's Hereditary Optic NeuropathyEtap 2Zakończone122021-11-30
A Study Investigating the Safety, Tolerability, and Efficacy of Elamipretide Topical Ophthalmic Solution for the Treatment of Fuchs' Corneal Endothelial Dystrophy (FCED)Etap 1, Etap 2Zakończone222021-09-17
An Open-Label, Phase 1 Clinical Study to Evaluate the Safety and Tolerability of Subcutaneous Elamipretide in Subjects With Intermediate Age-Related Macular DegenerationEtap 1Zakończone402020-10-20
Effects of Intravenous Bendavia™ on Reperfusion Injury in Patients Undergoing Angioplasty of the Renal ArteryEtap 1, Etap 2Przerwane162020-08-11
A Phase 2 Study to Evaluate the Cardiac and Renal Effects of Short Term Treatment With Elamipretide in Patients Hospitalized With Congestion Due to Heart FailureEtap 2Zakończone3082020-07-28
Safety, Tolerability, Efficacy of MTP-131 for Treatment of Mitochondrial Disease in Subjects From the MMPOWER StudyEtap 2Zakończone302020-07-17
A Phase 2 Study to Evaluate the Impact of MTP-131 (Bendavia™) on Skeletal Muscle Function in ElderlyEtap 2Zakończone412020-06-23
Evaluation of Myocardial Effects of MTP-131 for Reducing Reperfusion Injury in Patients With Acute Coronary EventsEtap 2Zakończone3002020-06-11
Effect of Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Reduced Ejection FractionEtap 2Zakończone712020-05-14
Safety, Tolerability, and Efficacy of MTP-131 for the Treatment of Mitochondrial MyopathyEtap 1, Etap 2Zakończone362019-12-27
A Study to Evaluate the Effects of 4 Weeks Treatment With Subcutaneous Elamipretide on Left Ventricular Function in Subjects With Stable Heart Failure With Preserved Ejection FractionEtap 2Zakończone462017-09-07
A Phase 1 Study Investigating the Safety and Pharmacokinetics of Repeat-dose Intravenous Infusion of MTP-131 in Subjects With Impaired Renal FunctionEtap 1Zakończone232015-11-18
A Study of MTP-131 Topical Ophthalmic Solution in Subjects With Diabetic Macular Edema and Non-Exudative Intermediate Age-related Macular DegenerationEtap 1, Etap 2Zakończone202015-10-26
A Multiple Ascending Dose Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Efficacy of Bendavia™ (MTP-131) in Patients With Heart FailureEtap 1Wycofane02015-10-15
A Study Investigating the Safety, Tolerability, and Pharmacokinetics of MTP-131 in Subjects With Congestive Heart FailureEtap 1Zakończone362015-09-17
Safety and Pharmacokinetic (PK) Study of Oral Bendavia Administered for 7 DaysEtap 1Zakończone302014-04-02
A Phase 1 Study Examining the Pharmacokinetics and Tolerability of a Single Oral Dose of Bendavia (MTP-131)Etap 1Zakończone302013-02-06
The Impact of Intravenous Bendavia™ on Endothelial Reactivity Dysfunction in Cigarette SmokingEtap 1Zakończone62012-04-19
Study to Evaluate Safety, Tolerability, and Pharmacokinetics (PK) of Intravenous (IV) Infusion of MTP-131 (Bendavia™) in Healthy AdultsEtap 1Zakończone402010-11-18