| Effect of mitochondrial-targeted antioxidants on glycaemic control, cardiovascular health, and oxidative stress in humans: A systematic review and meta-analysis of randomized controlled trials.Diabetes Obes Metab | Pooled analysis | 2022 |
| Initial Psychometric Evaluation of the Barth Syndrome Symptom Assessment (BTHS-SA) for Adolescents and Adults in a Phase 2 Clinical Study.Orphanet J Rare Dis | Random groups | 2025 |
| Genotype-specific effects of elamipretide in patients with primary mitochondrial myopathy: a post hoc analysis of the MMPOWER-3 trial.Orphanet J Rare Dis | Random groups | 2024 |
| Effect of Aficamten on Health Status Outcomes in Obstructive Hypertrophic Cardiomyopathy: Results From SEQUOIA-HCM.J Am Coll Cardiol | Random groups | 2024 |
| Elamipretide Topical Ophthalmic Solution for the Treatment of Subjects with Leber Hereditary Optic Neuropathy: A Randomized Trial.Ophthalmology | Random groups | 2024 |
| Identifying responders to elamipretide in Barth syndrome: Hierarchical clustering for time series data.Orphanet J Rare Dis | Random groups | 2023 |
| In vivo mitochondrial ATP production is improved in older adult skeletal muscle after a single dose of elamipretide in a randomized trial.PLoS One | Random groups | 2021 |
| A phase 2/3 randomized clinical trial followed by an open-label extension to evaluate the effectiveness of elamipretide in Barth syndrome, a genetic disorder of mitochondrial cardiolipin metabolism.Genet Med | Random groups | 2021 |
| Effects of Elamipretide on Left Ventricular Function in Patients With Heart Failure With Reduced Ejection Fraction: The PROGRESS-HF Phase 2 Trial.J Card Fail | Random groups | 2020 |
| The mitochondria-targeting peptide elamipretide diminishes circulating HtrA2 in ST-segment elevation myocardial infarction.Eur Heart J Acute Cardiovasc Care | Random groups | 2019 |
| Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide.Circ Heart Fail | Random groups | 2017 |
| Phase 2a Clinical Trial of Mitochondrial Protection (Elamipretide) During Stent Revascularization in Patients With Atherosclerotic Renal Artery Stenosis.Circ Cardiovasc Interv | Random groups | 2017 |
| Relation of Left Ventricular Mass and Infarct Size in Anterior Wall ST-Segment Elevation Acute Myocardial Infarction (from the EMBRACE STEMI Clinical Trial).Am J Cardiol | Random groups | 2016 |
| Effects of Single Vs. Multiple Sets during 10 Weeks of Water-based Resistance Training on Neuromuscular Adaptations in Young Women.Int J Sports Med | Random groups | 2016 |
| EMBRACE STEMI study: a Phase 2a trial to evaluate the safety, tolerability, and efficacy of intravenous MTP-131 on reperfusion injury in patients undergoing primary percutaneous coronary intervention.Eur Heart J | Random groups | 2016 |
| Comparison of the pharmacokinetics of a new 30 mg modified-release tablet formulation of metoclopramide for once-a-day administration versus 10 mg immediate-release tablets: a single and multiple-dose, randomized, open-label, parallel study in healthy male subjects.Eur J Drug Metab Pharmacokinet | Random groups | 2012 |
| Natural history comparison study to assess the efficacy of elamipretide in patients with Barth syndrome.Orphanet J Rare Dis | No random groups | 2022 |
| Antibodies to pancreatic duct cells in Sjögren's syndrome and rheumatoid arthritis.Gut | No random groups | 1977 |
| RePOWER: An International, Prospective, Non-Interventional Registry of Patients With Primary Mitochondrial Myopathy.Clin Genet | Group followed over time | 2026 |
| Elamipretide in pediatric Barth syndrome: from heart failure to school return.Orphanet J Rare Dis | Case reports | 2026 |
| Cardiac pathology in a patient with a novel pathogenic variant c.703del (p.Ile235SerfsTer4) of the TAFAZZIN gene.Cardiovasc Pathol | Case reports | 2025 |
| Elamipretide in the Management of Barth Syndrome: Current Evidence and a Case Report.Mol Genet Metab | Case reports | 2025 |
| Expanded-access use of elamipretide in a newborn with Barth syndrome: a case report.Eur Heart J Case Rep | Case reports | 2025 |
| Expanded-access use of elamipretide in a patient with membrane protein-associated neurodegeneration.Clin Case Rep | Case reports | 2024 |
| Mitochondrial Quality Control in Degenerative Musculoskeletal Diseases: Signaling Networks and Therapeutic Landscapes.Adv Sci (Weinh) | Review of studies | 2026 |
| Mitochondrial Quality Control in Inherited Mitochondrial Cardiomyopathy: Convergent Pathobiology and a Testable Therapeutic Framework.Int J Mol Sci | Review of studies | 2026 |
| The Oxidative-Mitochondrial-Inflammatory Axis in Retinitis Pigmentosa: Extracellular mtDNA as Biomarker and Therapeutic Read-Out.Antioxidants (Basel) | Review of studies | 2026 |
| Microvascular dysfunction and neurovascular signalling impairment in diabetic silent myocardial ischemia.Microvasc Res | Review of studies | 2026 |
| Redox imbalance and mitochondrial dysfunction in gestational diabetes mellitus: Implications for maternal health, placental function, and offspring metabolic programming.Free Radic Biol Med | Review of studies | 2026 |
| Reactive oxygen species and antioxidant strategies in human sperm cryodamage.Front Med (Lausanne) | Review of studies | 2026 |
| Targeting Mitochondria for Postoperative Cognitive Dysfunction: From Mechanisms to Therapeutics.Mol Neurobiol | Review of studies | 2026 |
| Clinical development in primary mitochondrial diseases at a translational inflection point: Lessons, mechanisms, and emerging therapeutic strategies.Biomed Pharmacother | Review of studies | 2026 |
| The Role of Oxidative Stress in Heart Failure: Mechanisms and Therapeutic Targets.Cureus | Review of studies | 2026 |
| Therapeutic targeting of mitochondrial dysfunction in heart failure: a systematic review & meta-analysis of clinical outcomes.Front Cardiovasc Med | Review of studies | 2026 |
| Drug repurposing in Alzheimer's disease: Emerging therapeutic strategies and promising candidates.Ageing Res Rev | Review of studies | 2026 |
| Cardiolipin remodelling in mitochondrial therapeutics: translational evidence chains from elamipretide to emerging strategies.Front Physiol | Review of studies | 2026 |
| Mitochondrial Dysfunction at the Intersection of CKM Syndrome: Molecular Mechanisms and Path-to-Target Therapies.Int J Mol Sci | Review of studies | 2026 |
| Effect of mitochondrial dysfunction on scar formation after spinal cord injury.Front Neurol | Review of studies | 2026 |
| Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives.Int J Mol Sci | Review of studies | 2026 |
| Mitochondrial dysfunction-driven inflammation and β-Cell apoptosis in type 2 diabetes mellitus: mechanistic insights and therapeutic implications.Mol Biol Rep | Review of studies | 2026 |
| Mitochondrial dysfunction, neuroinflammation, and associated mechanisms in sepsis-associated encephalopathy: from pathogenesis to emerging therapeutics.Front Neurosci | Review of studies | 2026 |
| Mitochondrial Calcium Dysregulation and Targeted Therapies in Heart Failure.Rev Cardiovasc Med | Review of studies | 2026 |
| Paradigm shift: from pulmonary vasodilation to cardiopulmonary dual-track therapy-a comprehensive review of pathophysiology and advances in pulmonary hypertension-associated right heart failure.Respir Res | Review of studies | 2026 |
| Elamipretide: First Approval.Drugs | Review of studies | 2026 |
| Mitochondria at the Crossroads of Cardiovascular Disease: Mechanistic Drivers and Emerging Therapeutic Strategies.Cells | Review of studies | 2026 |
| 2025 FDA TIDES (Peptides and Oligonucleotides) Harvest.Pharmaceuticals (Basel) | Review of studies | 2026 |
| New Insights on Mitochondria-Targeted Neurological Drugs.Biology (Basel) | Review of studies | 2026 |
| Mitochondrial Metabolic Checkpoints in Human Fertility: Reactive Oxygen Species as Gatekeepers of Gamete Competence.Cells | Review of studies | 2026 |
| Mitochondrial Dysfunction: The Cellular Bridge from Emotional Stress to Disease Onset: A Narrative Review.Biomolecules | Review of studies | 2026 |
| Therapeutic Approaches Involving Mitochondria in the Treatment of Acute Kidney Injury.Semin Nephrol | Review of studies | 2026 |
| Targeted nanoliposomal nutrient delivery for human health.World J Gastrointest Pharmacol Ther | Review of studies | 2025 |
| Role of Peptides in Skeletal Muscle Wasting: A Scoping Review.J Cachexia Sarcopenia Muscle | Review of studies | 2025 |
| Mitochondrial dysfunction, reactive oxygen species, and diabetes mellitus - A triangular relationship: A review.Biomol Biomed | Review of studies | 2025 |
| Role of the mitochondrial regulatory factor CHCHD2 in neurodegenerative diseases.Front Neurosci | Review of studies | 2025 |
| The Redox Revolution in Brain Medicine: Targeting Oxidative Stress with AI, Multi-Omics and Mitochondrial Therapies for the Precision Eradication of Neurodegeneration.Int J Mol Sci | Review of studies | 2025 |
| Dry Eye Disease: Oxidative Stress on Ocular Surface and Cutting-Edge Antioxidants.Glob Chall | Review of studies | 2025 |
| Advances in Management of Mitochondrial Myopathies.Int J Mol Sci | Review of studies | 2025 |
| Beyond the injection: delivery systems reshaping retinal disease management.Expert Opin Pharmacother | Review of studies | 2025 |
| Contemporary insights into elamipretide's mitochondrial mechanism of action and therapeutic effects.Biomed Pharmacother | Review of studies | 2025 |
| The Potential of Mitochondrial Therapeutics in the Treatment of Oxidative Stress and Inflammation in Aging.Mol Neurobiol | Review of studies | 2025 |
| Mitochondrial Dysfunction: The Silent Catalyst of Kidney Disease Progression.Cells | Review of studies | 2025 |
| Targeting the Electron Transport System for Enhanced Longevity.Biomolecules | Review of studies | 2025 |
| The Application and Molecular Mechanisms of Mitochondria-Targeted Antioxidants in Chemotherapy-Induced Cardiac Injury.Curr Issues Mol Biol | Review of studies | 2025 |
| Elamipretide: A Review of Its Structure, Mechanism of Action, and Therapeutic Potential.Int J Mol Sci | Review of studies | 2025 |
| Innovative technologies for the treatment of dry age-related macular degeneration (AMD) - modern therapeutic perspectives and their future.Rom J Ophthalmol | Review of studies | 2025 |
| Podocyte senescence: from molecular mechanisms to therapeutics.Ren Fail | Review of studies | 2024 |
| Nanozymes targeting mitochondrial repair in disease treatment.J Biotechnol | Review of studies | 2024 |
| The bioenergetics of traumatic brain injury and its long-term impact for brain plasticity and function.Pharmacol Res | Review of studies | 2024 |
| Cardiomyopathy in Duchenne Muscular Dystrophy and the Potential for Mitochondrial Therapeutics to Improve Treatment Response.Cells | Review of studies | 2024 |
| Challenging and target-based shifting strategies for heart failure treatment: An update from the last decades.Biochem Pharmacol | Review of studies | 2024 |
| Mitochondrial disorders leading to Alzheimer's disease-perspectives of diagnosis and treatment.Geroscience | Review of studies | 2024 |
| Genetic Mutations and Mitochondrial Redox Signaling as Modulating Factors in Hypertrophic Cardiomyopathy: A Scoping Review.Int J Mol Sci | Review of studies | 2024 |
| Mitofilin in cardiovascular diseases: Insights into the pathogenesis and potential pharmacological interventions.Pharmacol Res | Review of studies | 2024 |
| Application research of novel peptide mitochondrial-targeted antioxidant SS-31 in mitigating mitochondrial dysfunction.Mitochondrion | Review of studies | 2024 |
| Biomaterials Functionalized with Inflammasome Inhibitors-Premises and Perspectives.J Funct Biomater | Review of studies | 2024 |
| The emerging significance of mitochondrial targeted strategies in NAFLD treatment.Life Sci | Review of studies | 2023 |
| Temporal evolution of the heart failure phenotype in Barth syndrome and treatment with elamipretide.Future Cardiol | Review of studies | 2023 |
| Skeletal muscle mitochondrial remodeling in heart failure: An update on mechanisms and therapeutic opportunities.Biomed Pharmacother | Review of studies | 2022 |
| Targeting mitochondrial dysfunction with elamipretide.Heart Fail Rev | Review of studies | 2022 |
| Elamipretide for Barth syndrome cardiomyopathy: gradual rebuilding of a failed power grid.Heart Fail Rev | Review of studies | 2022 |
| Current and emerging drug targets in heart failure treatment.Heart Fail Rev | Review of studies | 2022 |
| SS-31, a Mitochondria-Targeting Peptide, Ameliorates Kidney Disease.Oxid Med Cell Longev | Review of studies | 2022 |
| Mitochondria as Therapeutic Targets in Heart Failure.Curr Heart Fail Rep | Review of studies | 2022 |
| Role of Mitochondrial Therapy for Ischemic-Reperfusion Injury and Acute Kidney Injury.Nephron | Review of studies | 2022 |
| Current and future treatment approaches for Barth syndrome.J Inherit Metab Dis | Review of studies | 2022 |
| Neuroprotective Effects of a Small Mitochondrially-Targeted Tetrapeptide Elamipretide in Neurodegeneration.Front Integr Neurosci | Review of studies | 2021 |
| Pharmacologic approaches to prevent skeletal muscle atrophy after spinal cord injury.Curr Opin Pharmacol | Review of studies | 2021 |
| Potential Therapeutic Candidates for Age-Related Macular Degeneration (AMD).Cells | Review of studies | 2021 |
| Mitochondrial dysfunction and beneficial effects of mitochondria-targeted small peptide SS-31 in Diabetes Mellitus and Alzheimer's disease.Pharmacol Res | Review of studies | 2021 |
| Barth syndrome cardiomyopathy: targeting the mitochondria with elamipretide.Heart Fail Rev | Review of studies | 2021 |
| Emerging Therapies in Nonexudative Age-Related Macular Degeneration in 2020.Asia Pac J Ophthalmol (Phila) | Review of studies | 2021 |
| Treatment of Leber's hereditary optic neuropathy: An overview of recent developments.Eur J Ophthalmol | Review of studies | 2020 |
| Mitochondrial targeted therapy with elamipretide (MTP-131) as an adjunct to tumor necrosis factor inhibition for traumatic optic neuropathy in the acute setting.Exp Eye Res | Review of studies | 2020 |
| Targeting reactive oxygen species (ROS) to combat the age-related loss of muscle mass and function.Biogerontology | Review of studies | 2020 |
| Oxidative stress and inflammation in the evolution of heart failure: From pathophysiology to therapeutic strategies.Eur J Prev Cardiol | Review of studies | 2020 |
| Advances in primary mitochondrial myopathies.Curr Opin Neurol | Review of studies | 2019 |
| Cardiolipin-targeted peptides rejuvenate mitochondrial function, remodel mitochondria, and promote tissue regeneration during aging.Arch Biochem Biophys | Review of studies | 2018 |
| Mitochondrial bioenergetics, redox state, dynamics and turnover alterations in renal mass reduction models of chronic kidney diseases and their possible implications in the progression of this illness.Pharmacol Res | Review of studies | 2018 |
| Targeting Oxidative Stress and Mitochondrial Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review.Antioxidants (Basel) | Review of studies | 2018 |
| Myocardial Energetics and Heart Failure: a Review of Recent Therapeutic Trials.Curr Heart Fail Rep | Review of studies | 2018 |
| Stealth Peptides Target Cellular Powerhouses to Fight Rare and Common Age-Related Diseases.Protein Pept Lett | Review of studies | 2018 |
| Mitochondrial genetics and therapeutic overview of Leber's hereditary optic neuropathy.Indian J Ophthalmol | Review of studies | 2017 |
| Therapies for mitochondrial diseases and current clinical trials.Mol Genet Metab | Review of studies | 2017 |
| Targeting mitochondrial function to treat optic neuropathy.Mitochondrion | Review of studies | 2017 |
| Targeting Mitochondrial Calcium Handling and Reactive Oxygen Species in Heart Failure.Curr Heart Fail Rep | Review of studies | 2017 |
| Targeting Metabolic Modulation and Mitochondrial Dysfunction in the Treatment of Heart Failure.Diseases | Review of studies | 2017 |
| Mitochondria-Targeted Antioxidants: Future Perspectives in Kidney Ischemia Reperfusion Injury.Oxid Med Cell Longev | Review of studies | 2016 |
| Serendipity and the discovery of novel compounds that restore mitochondrial plasticity.Clin Pharmacol Ther | Review of studies | 2014 |
| Mitochondria-targeted agents: Future perspectives of mitochondrial pharmaceutics in cardiovascular diseases.World J Cardiol | Review of studies | 2014 |
| Mitochondria-targeted therapies for acute kidney injury.Expert Rev Mol Med | Review of studies | 2014 |
| Mechanisms of skeletal muscle ageing; avenues for therapeutic intervention.Curr Opin Pharmacol | Review of studies | 2014 |
| Mitochondrial oxidative stress in aging and healthspan.Longev Healthspan | Review of studies | 2014 |
| First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics.Br J Pharmacol | Review of studies | 2014 |
| Is further improvement of the treatment of acute coronary syndromes still possible?Postepy Kardiol Interwencyjnej | Review of studies | 2013 |
| Mitochondrial approaches for neuroprotection.Ann N Y Acad Sci | Review of studies | 2008 |
| [Therapeutic options for patients with localized prostatic carcinoma: our experience with 454 patients].Actas Urol Esp | Review of studies | 2004 |
| Seawater immersion reshapes the temporal dynamics of traumatic brain injury and reveals mitochondrial oxidative stress as a modifiable therapeutic target.Exp Neurol | In animals | 2026 |
| Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats.Brain Behav Immun | In animals | 2026 |
| Oral Colon- and Mitochondria-Targeted Nanoparticles Alleviate Ulcerative Colitis by Reeducating Macrophage Polarization via SIRT3/FOXO3a-Mediated Mitochondrial Restoration.J Gastroenterol Hepatol | In animals | 2026 |
| Targeting Mitochondria in MASLD: Comparative Evaluation of MitoQ and SS-31 (Elamipretide) in Aged Female Mice under Nutritional Stress.Physiol Res | In animals | 2026 |
| Targeting Mitochondrial Dysfunction With Elamipretide (SS-31) Improves Skeletal Muscle Performance in a HFpEF Rat Model.Circ Heart Fail | In animals | 2026 |
| Breaking a mitochondrial danger-STING feed-forward amplifier preserves alveolar-capillary architecture and dampens interferon-chemokine signaling in acute lung injury.Tissue Cell | In animals | 2026 |
| Mitochondrial dysfunction drives age-related degeneration of the thoracic aorta.Geroscience | In animals | 2026 |
| Elamipretide (SS-31) and Nicotinamide Mononucleotide (NMN) Combination Therapy Targets TREM2 to Mitigate Post-ischemic Brain Injury in Mice.Neurochem Res | In animals | 2026 |
| Topology-Controlled PEGylation Enhances Renal Accumulation of Therapeutic Peptide for Treating Ischemia-Reperfusion Injury.Nano Lett | In animals | 2026 |
| Elamipretide (SS-31) promotes recovery by preserving mitochondrial bioenergetics and neural remodeling after spinal cord injury.Neurochem Int | In animals | 2026 |
| Peroxiredoxin Ⅲ safeguards cardiac function against doxorubicin by regulating mitochondrial quality control via H2O2 detoxification.Redox Biol | In animals | 2026 |
| Mitochondria-Targeted Liposomes Boost Thermogenesis for Adipose Tissue Regulation.Adv Healthc Mater | In animals | 2026 |
| Protective Effect of Mitochondria-Targeted Polydopamine Nanoparticles in Alleviating Hepatic Ischemia-Reperfusion Injury.ACS Nano | In animals | 2026 |
| SLC25A28 Ameliorates Hyperoxic Lung Injury by Improving Mitochondrial Oxidative Phosphorylation in Alveolar Epithelial Cells.Int J Mol Sci | In animals | 2026 |
| Early targets and progressive deterioration in cardiac performance in response to chronically modified cardiac troponin I.Am J Physiol Heart Circ Physiol | In animals | 2026 |
| NNT inhibits microglial activation via mitochondrial oxidative stress in spinal cord injury.Neurosci Lett | In animals | 2026 |
| SS-31 improves the quality of maternally aged oocytes by ameliorating mitochondrial function and metabolism.J Ovarian Res | In animals | 2026 |
| Mitochondrial Targeting by Elamipretide Improves Myocardial Bioenergetics Without Translating into Functional Benefits in HFpEF.Int J Mol Sci | In animals | 2026 |
| SS-31 improves post-cardiac arrest brain injury by inhibiting microglial ferroptosis and polarization.Neurotherapeutics | In animals | 2026 |
| Targeted Delivery of AGO-2 to Myocardial Mitochondria via Functionalized Nanoparticles Attenuates Oxidative Stress in Diabetic Cardiomyopathy.ACS Appl Mater Interfaces | In animals | 2025 |
| Endothelial Glycocalyx Degradation as a Mediator of Neuroinflammation and Cognitive Impairment in Aged Rats: Protective Role of SS-31.Mol Neurobiol | In animals | 2025 |
| Environmental enrichment highlights mitochondrial inner membrane function as a therapeutic target for sepsis-associated encephalopathy.Brain Res | In animals | 2025 |
| A Polytherapy Intervention in an Experimental Traumatic Optic Neuropathy Mouse Model.Ophthalmic Plast Reconstr Surg | In animals | 2025 |
| Elamipretide enhances post-thaw rooster sperm quality by mitigating oxidative stress and optimizing mitochondrial function during cryopreservation.Sci Rep | In animals | 2025 |
| Acute mitochondrial reactive oxygen species emissions drive mitochondrial dysfunction after traumatic muscle injury in male mice.Am J Physiol Cell Physiol | In animals | 2025 |
| Aging, mitochondrial dysfunction, and cerebral microhemorrhages: a preclinical evaluation of SS-31 (elamipretide) and development of a high-throughput machine learning-driven imaging pipeline for cerebromicrovascular protection therapeutic screening.Geroscience | In animals | 2025 |
| The Mitochondria-Targeted Peptide Therapeutic Elamipretide Improves Cardiac and Skeletal Muscle Function During Aging Without Detectable Changes in Tissue Epigenetic or Transcriptomic Age.Aging Cell | In animals | 2025 |
| The mitochondrial dysfunction regulated by JAK2/STAT3 pathway leads to the necroptosis in the renal cells under patulin exposure.Ecotoxicol Environ Saf | In animals | 2025 |
| SS-31: A promising therapeutic agent against bleomycin-induced pulmonary fibrosis in Mice.PLoS One | In animals | 2025 |
| Mitochondrial Cardiolipin-Targeted Tetrapeptide, SS-31, Exerts Neuroprotective Effects Within In Vitro and In Vivo Models of Spinal Cord Injury.Int J Mol Sci | In animals | 2025 |
| Telomere length in offspring is determined by mitochondrial-nuclear communication at fertilization.Nat Commun | In animals | 2025 |
| Acid-Triggered Cascaded Responsive Supramolecular Peptide Alleviates Myocardial Ischemia‒Reperfusion Injury by Restoring Redox Homeostasis and Protecting Mitochondrial Function.Adv Healthc Mater | In animals | 2025 |
| Effect of elamipretide and methylprednisolone treatment on optic nerve, retina and brain damage in a methanol poisoning model: biochemical and histopathological evaluation.Cutan Ocul Toxicol | In animals | 2025 |
| The potential of mitochondrially-targeted tetrapeptide in protecting against noise-induced hearing impairment.Neuroreport | In animals | 2025 |
| SS-31@Fer-1 Alleviates ferroptosis in hypoxia/reoxygenation cardiomyocytes via mitochondrial targeting.Biomed Pharmacother | In animals | 2025 |
| The Mitochondria-Targeted Micelle Inhibits Alzheimer's Disease Progression by Alleviating Neuronal Mitochondrial Dysfunction and Neuroinflammation.Small | In animals | 2025 |
| Synergistic effects of PS-NPs and Cd on ovarian toxicity in adolescent rats: Ferroptosis by induction of mitochondrial redox imbalance via the SIRT3-SOD2/Gpx4 pathway.Ecotoxicol Environ Saf | In animals | 2025 |
| Low expression of Frataxin might contribute to diabetic peripheral neuropathy in a mouse model.Biochem Biophys Res Commun | In animals | 2025 |
| Age-related changes of skeletal muscle metabolic response to contraction are also sex-dependent.J Physiol | In animals | 2025 |
| The involvement and possible targeting of cardiolipins degradation and disturbed linoleic acid metabolism in cardiac atrophy under cancer cachexia.Eur J Pharmacol | In animals | 2024 |
| New insight for SS‑31 in treating diabetic cardiomyopathy: Activation of mitoGPX4 and alleviation of mitochondria‑dependent ferroptosis.Int J Mol Med | In animals | 2024 |
| Effect of Elamipretide on the Vitrification of Mouse Ovarian Tissue by Freezing.Biopreserv Biobank | In animals | 2024 |
| Post-sepsis chronic muscle weakness can be prevented by pharmacological protection of mitochondria.Mol Med | In animals | 2024 |
| Mitochondria-targeting peptide SS-31 attenuates ferroptosis via inhibition of the p38 MAPK signaling pathway in the hippocampus of epileptic rats.Brain Res | In animals | 2024 |
| Skeletal muscle mitochondrial dysfunction mediated by Pseudomonas aeruginosa quorum-sensing transcription factor MvfR: reversing effects with anti-MvfR and mitochondrial-targeted compounds.mBio | In animals | 2024 |
| SS-31 treatment ameliorates cardiac mitochondrial morphology and defective mitophagy in a murine model of Barth syndrome.Sci Rep | In animals | 2024 |
| Mitochondrial antioxidant elamipretide improves learning and memory impairment induced by chronic sleep deprivation in mice.Brain Behav | In animals | 2024 |
| Hepatocyte mitochondrial DNA mediates macrophage immune response in liver injury induced by trichloroethylene.Ecotoxicol Environ Saf | In animals | 2024 |
| A free and user-friendly software protocol for the quantification of microfauna swimming behavior.Biotechniques | In animals | 2024 |
| Mitochondria-targeted reactive oxygen species blockor SS-31 blocks hepatic stellate cell activation and alleviates hepatic fibrosis by regulating NLRP3 inflammasomes.Cell Mol Biol (Noisy-le-grand) | In animals | 2024 |
| Role of Mitochondrial ROS for Calcium Alternans in Atrial Myocytes.Biomolecules | In animals | 2024 |
| Mitochondrial dysfunction and endoplasmic reticulum stress induced by activation of PPARα leaded testicular to apoptosis in SD rats explored to di-(2-ethylhexyl) phthalate (DEHP).Ecotoxicol Environ Saf | In animals | 2023 |
| Targeting mitochondria in the aged cerebral vasculature with SS-31, a proteomic study of brain microvessels.Geroscience | In animals | 2023 |
| Synovial fluid mitochondrial DNA concentration reflects the degree of cartilage damage after naturally occurring articular injury.Osteoarthritis Cartilage | In animals | 2023 |
| Intermittent treatment with elamipretide preserves exercise tolerance in aged female mice.Geroscience | In animals | 2023 |
| SS-31 alleviated nociceptive responses and restored mitochondrial function in a headache mouse model via Sirt3/Pgc-1α positive feedback loop.J Headache Pain | In animals | 2023 |
| Mitochondrial connexin43 and mitochondrial KATP channels modulate triggered arrhythmias in mouse ventricular muscle.Pflugers Arch | In animals | 2023 |
| Elamipretide mitigates ischemia-reperfusion injury in a swine model of hemorrhagic shock.Sci Rep | In animals | 2023 |
| The multi-tissue landscape of somatic mtDNA mutations indicates tissue-specific accumulation and removal in aging.Elife | In animals | 2023 |
| Peptide coacervate-Prussian blue hybrid supraparticle-tailored scaffolds for revitalizing diabetic heart valve regeneration via multiplex oxidative stress regulation.Biomaterials | In a lab dish | 2026 |
| Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury.J Mol Cell Cardiol | In a lab dish | 2012 |
| Mitochondria-derived reactive oxygen species mediate heme oxygenase-1 expression in sheared endothelial cells.J Pharmacol Exp Ther | In a lab dish | 2009 |
| Mitochondrial targeting with antioxidant peptide SS-31 prevents mitochondrial depolarization, reduces islet cell apoptosis, increases islet cell yield, and improves posttransplantation function.J Am Soc Nephrol | In a lab dish | 2007 |
| Pre-qualifications, learning strategies, and study satisfaction among medical students: insights from a multicenter German study.Med Educ Online | Other paper | 2026 |
| Mitochondria-targeted MXene-based nanozymes promote mitophagy and inhibit mtDNA-triggered cGAS/STING inflammation in osteoarthritis.Bioact Mater | Other paper | 2026 |
| Report from the 2026 Barth Syndrome Foundation International Scientific, Medical & Family Conference: Advances in Barth Syndrome Research, Therapy Development, and Clinical Care.J Dev Biol | Other paper | 2026 |
| Mitochondria-targeted peptide elamipretide alleviates cisplatin-induced ovarian failure by activating the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 pathway.Front Pharmacol | Other paper | 2026 |
| Elamipretide Rejuvenates Oocyte Quality and Restores Female Fertility During Reproductive Aging.Aging Cell | Other paper | 2026 |
| Engineered Mitochondria-Targeted Biomimetic Hybrid Nanovesicles Ameliorate Rheumatoid Arthritis via Regulating Macrophage Autophagy and cGAS-STING Signaling.ACS Appl Mater Interfaces | Other paper | 2026 |
| Elamipretide: a mitochondria-targeting drug for Barth syndrome.Trends Pharmacol Sci | Other paper | 2026 |
| Mitochondrial-targeted SS-31 peptide attenuates radiation-induced cardiomyocyte senescence.J Radiat Res | Other paper | 2026 |
| AMCP Market Insights: Managed care considerations in Barth syndrome.J Manag Care Spec Pharm | Other paper | 2026 |
| Mitochondrial-Targeted SS-31 Attenuates the Doxorubicin-Induced Cardiomyoblast H9C2 Cell Senescence.Biology (Basel) | Other paper | 2026 |
| Is an emerging pharmacotherapeutic era for rare mitochondrial diseases here?Cell Metab | Other paper | 2026 |
| Therapeutic Peptide SS-31 Modulates Membrane Binding and Aggregation of α-Synuclein and Restores Impaired Mitochondrial Function.Chem Biol Drug Des | Other paper | 2026 |
| Synergistic mitochondrial homeostasis regulation and cholinergic circuits reconstruction via a one-step synthesized multifunctional hydrogel facilitates spinal cord injury repair.Bioact Mater | Other paper | 2026 |
| Patient self-selection does not influence postoperative improvements in pain, function, or satisfaction in ream-and-run arthroplasty patients.J Shoulder Elbow Surg | Other paper | 2026 |
| Restoring cardiolipin homeostasis mitigates cerebral ischemia-reperfusion injury by suppressing ATG5-mediated neuronal autophagy-dependent ferroptosis.J Adv Res | Other paper | 2026 |
| Energy-replenishing, mitochondria-targeted hydrogel microspheres mitigate sarcopenia via cellular senescence amelioration.J Control Release | Other paper | 2026 |
| Mechanisms of Anti-Oxidants, N-Acetylcysteine and Elamipretide (SS-31), on Ozone-Induced Airway Hyperresponsiveness and Mucus Hypersecretion.Lung | Other paper | 2026 |
| Mitochondria dysfunction and increased expression of WNT5A and BNIP3 in tenocytes obtained from patients with tendinopathy.JSES Int | Other paper | 2026 |
| Association of hippocampus, entorhinal cortex, and amygdala with thyroid function: a bilateral volumetric analysis.Thyroid Res | Other paper | 2026 |
| Elamipretide Hydrochloride.Am J Health Syst Pharm | Other paper | 2026 |
| Disruption of hippocampal mitochondrial function underlies opioid-induced postoperative cognitive dysfunction in aged rats.bioRxiv | Other paper | 2026 |
| Cuproptosis of bronchial epithelial cells triggers airway remodeling in chronic asthma.Sci Rep | Other paper | 2026 |
| Elamipretide Improves Mitochondrial Function in Mitochondrial Trifunctional Protein-Deficient Mice and Human Fibroblasts.J Inherit Metab Dis | Other paper | 2026 |
| Mitochondria-Targeted Peptides and Bilayer Composition Modulate Membrane Electroporation under Elevated Electrochemical Stress.Langmuir | Other paper | 2025 |
| Real-world disease burden and health care resource utilization for patients with Barth syndrome.J Med Econ | Other paper | 2025 |
| SS-31 Targets NOS2 to Enhance Osteogenic Differentiation in Aged BMSCs by Restoring Mitochondrial Function.Organogenesis | Other paper | 2025 |
| Targeting ANT1 to regulate PINK1/Parkin-mediated mitophagy is an effective treatment of trauma-induced tendon heterotopic ossification.J Orthop Translat | Other paper | 2025 |
| YTHDF1-mediated mitochondrial dysfunction and allergic airway inflammation by interaction with β-catenin/TCF4 signaling.Int Immunopharmacol | Other paper | 2025 |
| Sirt6 deficiency exacerbates angiotensin II-induced lipid nephrotoxicity by affecting PLD6-derived cardiolipin metabolism in podocytes.Cell Signal | Other paper | 2025 |
| Deciphering the Effects of Quenching on the Chemodiversity of Low- and Non-volatile Disinfection Byproducts in Drinking Source Water Using ESI(-)-FT-ICR MS.Environ Sci Technol | Other paper | 2025 |
| Mitochondrial-Targeted Protective Potential of Elamipretide for the In Vitro Production of Porcine Embryos.Animals (Basel) | Other paper | 2025 |
| Examination of mitochondria- and inflammasome-mediated mechanisms of clozapine-induced myocarditis using patient-derived iPSC cardiomyocytes.Mol Psychiatry | Other paper | 2025 |
| Szeto-Schiller 31 eases acute lung injury in neonatal mice with acute respiratory distress syndrome by mediating TXNIP expression and NLRP3 inflammasome activation.Transl Pediatr | Other paper | 2025 |
| The Efficacy and Sustainability of an Implementation Intervention (FOCUS Program) on Linkage to Hepatitis C Care Time at a Community Health Center in the Deep South: A Longitudinal Study Based on Electronic Medical Records.J Viral Hepat | Other paper | 2025 |
| [Down-regulation of ACADM-mediated lipotoxicity inhibits invasion and metastasis of estrogen receptor-positive breast cancer cells].Nan Fang Yi Ke Da Xue Xue Bao | Other paper | 2025 |
| Polyphosphate- and Antioxidant Peptide-Based Coacervate Delivers miRNA.ACS Appl Mater Interfaces | Other paper | 2025 |
| Mitochondrial Dysfunction Drives Age-Related Degeneration of the Thoracic Aorta.bioRxiv | Other paper | 2025 |
| A multifunctional mitochondria-protective gene delivery platform promote intervertebral disc regeneration.Biomaterials | Other paper | 2025 |
| What do employers need when supporting stroke survivors to return to work?: a mixed-methods study.Top Stroke Rehabil | Other paper | 2025 |
| Enhancing Mitochondrial Function Through Pharmacological Modification: A Novel Approach to Mitochondrial Transplantation in a Sepsis Model.Biomedicines | Other paper | 2025 |
| Milk-derived exosome-loaded SS31 as a novel strategy to mitigate UV-induced photodamage in skin.J Photochem Photobiol B | Other paper | 2025 |
| Reprogramming of Treg cell-derived small extracellular vesicles effectively prevents intestinal inflammation from PANoptosis by blocking mitochondrial oxidative stress.Trends Biotechnol | Other paper | 2025 |
| Cadmium-cardiolipin disruption of respirasome assembly and redox balance through mitochondrial membrane rigidification.J Lipid Res | Other paper | 2025 |
| ReCLAIM-2: A Randomized Phase II Clinical Trial Evaluating Elamipretide in Age-related Macular Degeneration, Geographic Atrophy Growth, Visual Function, and Ellipsoid Zone Preservation.Ophthalmol Sci | Other paper | 2025 |
| Age-related changes of skeletal muscle metabolic response to contraction are also sex-dependent.J Physiol | Other paper | 2025 |
| Expanded-Access Use of Elamipretide Improves Quality of Life in Patients With Rare Mitochondrial Disorders Characterized by Ophthalmic Symptoms: A Case Series.Clin Case Rep | Other paper | 2024 |
| The mitochondrial-targeted peptide therapeutic elamipretide improves cardiac and skeletal muscle function during aging without detectable changes in tissue epigenetic or transcriptomic age.bioRxiv | Other paper | 2024 |
| SS-31 modification alleviates ferroptosis induced by superparamagnetic iron oxide nanoparticles in hypoxia/reoxygenation cardiomyocytes.Heliyon | Other paper | 2024 |
| Scar sarcoidosis: Clinical features and prognostic significance.Sarcoidosis Vasc Diffuse Lung Dis | Other paper | 2024 |
| Discovery of novel SS-31 (d-Arg-dimethylTyr-Lys-Phe-NH2) derivatives as potent agents to ameliorate inflammation and increase mitochondrial ATP synthesis.RSC Adv | Other paper | 2024 |
| SS-31 mitigates oxidative stress and restores mitochondrial function in cigarette smoke-damaged oral epithelial cells via PINK1-mediated mitophagy.Chem Biol Interact | Other paper | 2024 |
| Silver nanoparticle-induced cell damage via impaired mtROS-JNK/MnSOD signaling pathway.Toxicol Mech Methods | Other paper | 2024 |
| Megalin-targeting and ROS-responsive elamipretide-conjugated polymeric prodrug for treatment of acute kidney injury.Biomed Pharmacother | Other paper | 2024 |
| Expanded-access use of elamipretide in a critically ill patient with Barth syndrome.Genet Med Open | Other paper | 2024 |
| SS-31 inhibits the inflammatory response by increasing ATG5 and promoting autophagy in lipopolysaccharide-stimulated HepG2 cells.Biochem Biophys Res Commun | Other paper | 2024 |