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Ministerstwo zdrowia USA opublikowało projekt zasad, według którego nie będzie ścigać aptek przygotowujących BPC-157 na receptę dla konkretnej osoby, dopóki FDA nie zdecyduje w przepisach. To nadal nie jest dopuszczony lek.
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Prace naukowe

BadaniaRodzaj badaniaRok
Predictors of Physical and Functional Loss in Advanced-Stage Lung Cancer Patients Receiving Platinum Chemotherapy.J Thorac OncolZ losowaniem grup2018
A Phase II Clinical Trial of Pembrolizumab and Enobosarm in Patients with Androgen Receptor-Positive Metastatic Triple-Negative Breast Cancer.OncologistBez losowania grup2021
Pharmacokinetic drug interactions of the selective androgen receptor modulator GTx-024(Enobosarm) with itraconazole, rifampin, probenecid, celecoxib and rosuvastatin.Invest New DrugsBez losowania grup2016
Evidence of ostarine cross-contamination via sweat in 2 athletes sharing the same neoprene hamstring sleeves. An original situation of drug transfer where the anti-doping rule violation was suspended by the sport authorities.Clin Chim ActaOpisy przypadków2024
Liver Injury after Selective Androgen Receptor Modulator Intake: A Case Report and Review of the Literature.Z GastroenterolOpisy przypadków2024
Body fluid contamination in the context of an adverse analytical finding in doping: About a case involving ostarine.Clin Chim ActaOpisy przypadków2024
RAD-140 Drug-Induced Liver Injury.Ochsner JOpisy przypadków2022
Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and literature review.World J Clin CasesOpisy przypadków2021
Drug-Induced Liver Injury From Enobosarm (Ostarine), a Selective Androgen Receptor Modulator.ACG Case Rep JOpisy przypadków2021
Selective Androgen Receptor Modulators (SARMs) in Sport: Patterns of Use, Product Contamination, Health Risks and Doping-Control Implications.Drug Test AnalPrzegląd badań2026
An Update on the Role of Androgens and Androgen Receptor in Triple-Negative Breast Cancer.CellsPrzegląd badań2026
Sarcopenia in Aging: Pathogenesis, Diagnosis, and Emerging Therapeutic Frontiers.Mol Imaging BiolPrzegląd badań2026
Pharmacological intervention: Challenges and promising outcomes for fat loss and preservation of lean body mass in the treatment of overweight and type 2 diabetes.Diabetes Obes MetabPrzegląd badań2026
Pharmacologic Treatments for the Preservation of Lean Body Mass During Weight Loss.J Clin MedPrzegląd badań2026
Current Status and Advances in Anti-Androgen Therapy for Triple-Negative Breast Cancer.Curr Med SciPrzegląd badań2025
The Potential of SARMs and Antimyostatin Agents in Addressing Lean Body Mass Loss From GLP-1 Agonists: A Literature Review.J DiabetesPrzegląd badań2025
Selective androgen receptor modulators (SARMs) - potential anabolic drugs for the treatment of cachexia and frailty syndrome.Endokrynol PolPrzegląd badań2025
The relationship between muscle mass and function in cancer cachexia: smoke and mirrors?Curr Opin Support Palliat CarePrzegląd badań2018
Pharmacological management of cachexia in adult cancer patients: a systematic review of clinical trials.BMC CancerPrzegląd badań2018
Detection of SARMs in doping control analysis.Mol Cell EndocrinolPrzegląd badań2018
Overcoming obstacles in the design of cancer anorexia/weight loss trials.Crit Rev Oncol HematolPrzegląd badań2017
Novel therapeutic options for cachexia and sarcopenia.Expert Opin Biol TherPrzegląd badań2016
Study Design and Rationale for the Phase 3 Clinical Development Program of Enobosarm, a Selective Androgen Receptor Modulator, for the Prevention and Treatment of Muscle Wasting in Cancer Patients (POWER Trials).Curr Oncol RepPrzegląd badań2016
Clinical results in cachexia therapeutics.Curr Opin Clin Nutr Metab CarePrzegląd badań2016
Skeletal muscle atrophy: Potential therapeutic agents and their mechanisms of action.Pharmacol ResPrzegląd badań2015
Treatment of cachexia: An overview of recent developments.Int J CardiolPrzegląd badań2015
Treatment of cachexia: an overview of recent developments.J Am Med Dir AssocPrzegląd badań2014
Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer.Curr Opin Support Palliat CarePrzegląd badań2013
Highlights of mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology.Arch Med SciPrzegląd badań2013
Highlights of the mechanistic and therapeutic cachexia and sarcopenia research 2010 to 2012 and their relevance for cardiology.Int J CardiolPrzegląd badań2013
Miscellaneous agents--cytotoxics and hormonal agents.J Thorac OncolPrzegląd badań2012
An update on promising agents for the treatment of cancer cachexia.Curr Opin Support Palliat CarePrzegląd badań2009
Nonsteroidal selective androgen receptor modulator Ostarine in cancer cachexia.Future OncolPrzegląd badań2009
Improvement of Bone Healing by Combined Treatment with Selective Androgen and Estrogen Receptor Modulators in Female and Male Rats.Calcif Tissue IntNa zwierzętach2026
Comprehensive IM-MS approach for SARMs detection in urine: building CCS databases to support food safety monitoring.Food Addit Contam Part A Chem Anal Control Expo Risk AssessNa zwierzętach2026
Effect of ostarine on glucose level, lipid profile, and osteoporosis in streptozotocin induced diabetic male rats.Can J Physiol PharmacolNa zwierzętach2026
Effects of Combined Treatment With Selective Androgen and Estrogen Receptor Modulators Ostarine and Raloxifen on Bone Tissue In Ovariectomized Rats.Calcif Tissue IntNa zwierzętach2025
Ostarine blunts the effect of endurance training on submaximal endurance in rats.Naunyn Schmiedebergs Arch PharmacolNa zwierzętach2024
Advantage of ostarine over raloxifene and their combined treatments for muscle of estrogen-deficient rats.J Endocrinol InvestNa zwierzętach2024
Sex-specific cytotoxicity of ostarine in cardiomyocytes.Mol Cell EndocrinolNa zwierzętach2023
Treatment of osteoporosis using a selective androgen receptor modulator ostarine in an orchiectomized rat model.EndocrineNa zwierzętach2023
Ostarine does not enhance the metabolic effect of exercise in obese rats.J Physiol PharmacolNa zwierzętach2023
A combined treatment with selective androgen and estrogen receptor modulators prevents bone loss in orchiectomized rats.J Endocrinol InvestNa zwierzętach2022
Combination of selective androgen and estrogen receptor modulators in orchiectomized rats.J Endocrinol InvestNa zwierzętach2022
Ostarine-Induced Myogenic Differentiation in C2C12, L6, and Rat Muscles.Int J Mol SciNa zwierzętach2022
Effect of Selective Androgen Receptor Modulator Enobosarm on Bone Healing in a Rat Model for Aged Male Osteoporosis.Calcif Tissue IntNa zwierzętach2020
Ostarine and Ligandrol Improve Muscle Tissue in an Ovariectomized Rat Model.Front Endocrinol (Lausanne)Na zwierzętach2020
Development of a multi-residue high-throughput UHPLC-MS/MS method for routine monitoring of SARM compounds in equine and bovine blood.Drug Test AnalNa zwierzętach2020
Overcoming resistance to anabolic SARM therapy in experimental cancer cachexia with an HDAC inhibitor.EMBO Mol MedNa zwierzętach2020
The Selective Androgen Receptor Modulator Ostarine Improves Bone Healing in Ovariectomized Rats.Calcif Tissue IntNa zwierzętach2020
Synthesis of Aryl Propionamide Scaffold Containing a Pentafluorosulfanyl Moiety as SARMs.MoleculesNa zwierzętach2019
Effect of ostarine (enobosarm/GTX024), a selective androgen receptor modulator, on adipocyte metabolism in Wistar rats.J Physiol PharmacolNa zwierzętach2019
Specific characterization of non-steroidal selective androgen peceptor modulators using supercritical fluid chromatography coupled to ion-mobility mass spectrometry: application to the detection of enobosarm in bovine urine.Drug Test AnalNa zwierzętach2017
Investigation of the selective androgen receptor modulators S1, S4 and S22 and their metabolites in equine plasma using high-resolution mass spectrometry.Rapid Commun Mass SpectromNa zwierzętach2016
Enobosarm (GTx-024) Modulates Adult Skeletal Muscle Mass Independently of the Androgen Receptor in the Satellite Cell Lineage.EndocrinologyNa zwierzętach2015
Absorption, distribution, metabolism and excretion of the novel SARM GTx-024 [(S)-N-(4-cyano-3-(trifluoromethyl)phenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide] in rats.XenobioticaNa zwierzętach2013
Limitations of Molecular Docking in Predicting the Selectivity of Selective Androgen Receptor Modulators (SARMs): A Comparative Study of YK11 and Ostarine Across Five Nuclear Receptors.Int J Mol SciInna praca2026
Manhole Sampling at Gyms and Sports Centers in Denmark: A Pilot Study Using Wastewater Analysis as a Tool for Monitoring the Use of Performance-Enhancing Drugs.Drug Test AnalInna praca2026
Muscle Loss in Obesity Therapy as a Therapeutic Target: Trial Design and Endpoints for Regulatory Discussions.J Cachexia Sarcopenia MuscleInna praca2025
A Computational and In Vitro Appraisal of Ostarine to Target Androgen Receptor in Glioma C6 Cells.Cell Biochem BiophysInna praca2025
SARMs, Metabolic Modulators and Growth Hormone Secretagogues in Suspected Illegal Medicines, Bought as Sport Performance Enhancers: A Retro- and Prospective Study Within the GEON.Drug Test AnalInna praca2025
Rapid detection of illegal selective androgen receptor modulators in unregistered supplements using a combination of selected solid-state analytical methods.ADMET DMPKInna praca2025
Sarcopenia in Ageing and Chronic Illness: Trial Endpoints and Regulatory Issues.J Cachexia Sarcopenia MuscleInna praca2025
Detection of anabolic agents including selective androgen receptor modulators in samples outside of sport.Drug Test AnalInna praca2024
The disordering effect of SARMs on a biomembrane model.Phys Chem Chem PhysInna praca2024
In Vitro and In Vivo Human Metabolism of Ostarine, a Selective Androgen Receptor Modulator and Doping Agent.Int J Mol SciInna praca2024
Evidence of ostarine excretion in oral fluid after a single controlled oral administration.Clin Chim ActaInna praca2024
A screening method for the quantitative determination of selective androgen receptor modulators (SARMs) in capsules by high resolution 19F- and 1H-NMR spectroscopy.Anal MethodsInna praca2024
An Ultra-High-Performance Liquid Chromatography Coupled with Tandem Mass Spectrometry Method with Online Solid-Phase Extraction Sample Preparation for the High-Throughput and Sensitive Determination of Ostarine in Human Urine.Methods ProtocInna praca2024
Selective Androgen Receptor Modulators Combined with Treadmill Exercise Have No Bone Benefit in Healthy Adult Rats.Pharmaceuticals (Basel)Inna praca2023
Molecular docking analysis of MCL-1 inhibitors for breast cancer management.BioinformationInna praca2023
The forensic response after an adverse analytical finding (doping) involving a selective androgen receptor modulator (SARM) in human athlete.J Pharm Biomed AnalInna praca2022
Imaging Androgen Receptors in Breast Cancer with 18F-Fluoro-5α-Dihydrotestosterone PET: A Pilot Study.J Nucl MedInna praca2022
Development and validation of SARMs and metabolic modulators screening in hair using UHPLC-MS/MS: Application to a doping case and first identification of S23 in authentic human hair.J Chromatogr B Analyt Technol Biomed Life SciInna praca2021
Ostarine attenuates pyocyanin in Pseudomonas aeruginosa by interfering with quorum sensing systems.J Antibiot (Tokyo)Inna praca2021
Peroxisome Proliferator-Activated Receptor Delta Agonist (PPAR- δ) and Selective Androgen Receptor Modulator (SARM) Abuse: Clinical, Analytical and Biological Data in a Case Involving a Poisonous Combination of GW1516 (Cardarine) and MK2866 (Ostarine).ToxicsInna praca2021
Novel Agents Show Promise Against Acquired Endocrine Resistance in ER+ Advanced Breast Cancer.OncologistInna praca2021
Perspectives in Evaluating Selective Androgen Receptor Modulators in Human Hair: A Short Communication.Ther Drug MonitInna praca2021
Simultaneous detection of different chemical classes of selective androgen receptor modulators in urine by liquid chromatography-mass spectrometry-based techniques.J Pharm Biomed AnalInna praca2021
High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction.Drug Test AnalInna praca2021
Elimination profiles of microdosed ostarine mimicking contaminated products ingestion.Drug Test AnalInna praca2020
Identification of S22 (ostarine) in human nails and hair using LC-HRMS. Application to two authentic cases.Drug Test AnalInna praca2020
Enhanced UHPLC-MS/MS screening of selective androgen receptor modulators following urine hydrolysis.MethodsXInna praca2020
Computed tomographic assessment of lean body mass in patients on selective androgen receptor modulator.Clin ImagingInna praca2020
A novel approach to the quantification of urinary aryl-propionamide-derived SARMs by UHPLC-MS/MS.Biomed ChromatogrInna praca2020
A new series of bicalutamide, enzalutamide and enobosarm derivatives carrying pentafluorosulfanyl (SF5) and pentafluoroethyl (C2F5) substituents: Improved antiproliferative agents against prostate cancer.Eur J Med ChemInna praca2019
Selective androgen receptor modulators (SARMs) have specific impacts on the mouse uterus.J EndocrinolInna praca2019
TiO2 Photocatalyzed Oxidation of Drugs Studied by Laser Ablation Electrospray Ionization Mass Spectrometry.J Am Soc Mass SpectromInna praca2019
Evaluation of ostarine as a selective androgen receptor modulator in a rat model of postmenopausal osteoporosis.J Bone Miner MetabInna praca2019
Novel Trifluoromethylated Enobosarm Analogues with Potent Antiandrogenic Activity In Vitro and Tissue Selectivity In Vivo.Mol Cancer TherInna praca2018
Silver linings on the horizon: highlights from the 10th Cachexia Conference.J Cachexia Sarcopenia MuscleInna praca2018
Prevention of body weight loss and sarcopenia by a novel selective androgen receptor modulator in cancer cachexia models.Oncol LettInna praca2017
Analytical strategies to detect enobosarm administration in bovines.Food Addit Contam Part A Chem Anal Control Expo Risk AssessInna praca2017
Tissue Selective Androgen Receptor Modulators (SARMs) Increase Pelvic Floor Muscle Mass in Ovariectomized Mice.J Cell BiochemInna praca2017
Highlights from the 7th Cachexia Conference: muscle wasting pathophysiological detection and novel treatment strategies.J Cachexia Sarcopenia MuscleInna praca2014
Enobosarm (GTx-024, S-22): a potential treatment for cachexia.Future OncolInna praca2014
Computer-aided (in silico) approaches in the mode-of-action analysis and safety assessment of ostarine and 4-methylamphetamine.Hum PsychopharmacolInna praca2013
Selective androgen receptor modulators: in vitro and in vivo metabolism and analysis.Food Addit Contam Part A Chem Anal Control Expo Risk AssessInna praca2013
Trafficking of drug candidates relevant for sports drug testing: detection of non-approved therapeutics categorized as anabolic and gene doping agents in products distributed via the Internet.Drug Test AnalInna praca2011

Te prace znaleźliśmy automatycznie w bazie PubMed. Redakcja jeszcze ich nie przeczytała i nie wpływają na żadną ocenę. Tytuły są w oryginale. W każdej grupie pokazujemy najnowsze prace do ustalonego limitu. Pełną listę ma PubMed.

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Zarejestrowane badania na ludziach (17)

BadaniaEtapStatusLiczba uczestnikówAktualizacja
Proof-of-Concept Study Evaluating Total Body Weight, Physical Function & Safety of Enobosarm in Patients Treated With GLP-1 Receptor Agonist, for Weight LossEtap 2Trwa, bez nowych osób2392026-09-04
Dose-Finding Study Evaluating Effect on Body Composition of Enobosarm in Patients Taking a GLP-1 for Chronic Weight MgmtEtap 2Zakończone1682025-09-17
Phase II Study of GTx024 in Women With Metastatic Breast CancerEtap 2Przerwane222024-03-08
Study to Assess Long-Term Safety/Tolerability of Enobosarm (GTx 024) in Stress Urinary IncontinenceEtap 2Wycofane02024-03-01
Add-on Study for Protocol G200802 (NCT02463032): Effect of GTx-024 on Maximal Neuromuscular Function and Lean Body MassEtap 2Wycofane02024-02-26
Efficacy & Safety Evaluation of Enobosarm in Combo With Abemaciclib in Treatment of ER+HER2- Metastatic Breast CancerEtap 3Przerwane52024-02-26
Pembrolizumab and Enobosarm in Treating Patients With Androgen Receptor Positive Metastatic Triple Negative Breast CancerEtap 2Zakończone182024-02-20
Efficacy Evaluation of Enobosarm Monotherapy in Treatment of AR+/ER+/HER2- Metastatic Breast CancerEtap 3Przerwane522024-01-26
Durability Extension Study to Assess Clinical Activity and Safety of Enobosarm (GTx-024) in Stress Urinary IncontinenceEtap 2Wycofane02023-09-14
Study to Assess Enobosarm (GTx-024) in Postmenopausal Women With Stress Urinary IncontinenceEtap 2Zakończone4912021-03-24
GTx-024 as a Treatment for Stress Urinary Incontinence in WomenEtap 2Zakończone192021-02-01
Efficacy and Safety of GTx-024 in Patients With Estrogen Receptor (ER)+/Androgen Receptor (AR)+ Breast CancerEtap 2Zakończone1362020-12-09
Efficacy and Safety of GTx-024 in Patients With Androgen Receptor-Positive Triple Negative Breast Cancer (AR+ TNBC)Etap 2Przerwane322020-11-18
Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC) on First Line PlatinumEtap 3Zakończone3302020-11-09
Enobosarm and Anastrozole in Pre-menopausal Women With High Mammographic Breast DensityEtap 1Zakończone92018-04-18
Phase III Study of the Effect of GTx-024 on Muscle Wasting in Patients With Non-Small Cell Lung Cancer (NSCLC)Etap 3Zakończone3212016-03-03
Study of GTx-024 on Muscle Wasting (Cachexia) Cancer.Etap 2Zakończone1592014-07-11