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| Rapamycin Does Not Compromise Exercise-Induced Muscular Adaptations in Female Mice.Aging Cell | Na zwierzętach | 2025 |
| Deletion of ZNRF2 Exacerbates MPTP-Induced Parkinson's Disease by Activating mTOR-Mediated Neuroinflammatory Pathways.Mol Neurobiol | Na zwierzętach | 2025 |
| Lysosomes signal through the epigenome to regulate longevity across generations.Science | Na zwierzętach | 2025 |
| Kinetics of thymic regeneration in female mice following short-term rapamycin administration.Eur J Pharmacol | Na zwierzętach | 2025 |
| Impacts of a high-glucose diet or starvation on microRNA-transcription factor networks in Caenorhabditis elegans through Boolean mathematical modeling.Biosystems | Na zwierzętach | 2025 |
| AKT2/mTOR/VEGF Signaling Attenuates Aging-Related Male Infertility by Suppressing Epididymal Autophagy and Apoptosis via Extracellular Vesicle-Mediated Sperm Rescue.FASEB J | Na zwierzętach | 2025 |
| Sestrins regulate muscle stem cell metabolic homeostasis.Stem Cell Reports | W probówce | 2021 |
| Pharmacological inhibition of the PI3K/PTEN/Akt and mTOR signalling pathways limits follicle activation induced by ovarian cryopreservation and in vitro culture.J Ovarian Res | W probówce | 2021 |
| CREB activity is required for mTORC1 signaling-induced primordial follicle activation in mice.Histochem Cell Biol | W probówce | 2020 |
| The Effects of IL-1β on Astrocytes are Conveyed by Extracellular Vesicles and Influenced by Age.Neurochem Res | W probówce | 2020 |
| Rapamycin retards epigenetic ageing of keratinocytes independently of its effects on replicative senescence, proliferation and differentiation.Aging (Albany NY) | W probówce | 2019 |
| Individual response to mTOR inhibition in delaying replicative senescence of mesenchymal stromal cells.PLoS One | W probówce | 2019 |
| Knockdown of insulin-like growth factor 1 exerts a protective effect on hypoxic injury of aged BM-MSCs: role of autophagy.Stem Cell Res TherWycofane | W probówce | 2018 |
| Muscle Protein Anabolic Resistance to Essential Amino Acids Does Not Occur in Healthy Older Adults Before or After Resistance Exercise Training.J Nutr | W probówce | 2018 |
| mTOR pathway activation drives lung cell senescence and emphysema.JCI Insight | W probówce | 2018 |
| MAPK3/1 participates in the activation of primordial follicles through mTORC1-KITL signaling.J Cell Physiol | W probówce | 2018 |
| Celastrol alleviates angiotensin II‑mediated vascular smooth muscle cell senescence via induction of autophagy.Mol Med Rep | W probówce | 2017 |
| Chronic exposure to rapamycin and episodic serum starvation modulate ageing of human fibroblasts in vitro.Biogerontology | W probówce | 2017 |
| Rapamycin inhibits the secretory phenotype of senescent cells by a Nrf2-independent mechanism.Aging Cell | W probówce | 2017 |
| Inhibition of mTOR induces a paused pluripotent state.Nature | W probówce | 2016 |
| Reduced autophagy leads to an impaired ferritin turnover in senescent fibroblasts.Free Radic Biol Med | W probówce | 2016 |
| Thyroid Hormones Enhance Mitochondrial Function in Human Epidermis.J Invest Dermatol | W probówce | 2016 |
| Melatonin Treatment Improves Mesenchymal Stem Cells Therapy by Preserving Stemness during Long-term In Vitro Expansion.Theranostics | W probówce | 2016 |
| Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains.Nat Commun | W probówce | 2015 |
| Elevated ATF4 function in fibroblasts and liver of slow-aging mutant mice.J Gerontol A Biol Sci Med Sci | W probówce | 2015 |
| Dysfunctional survival-signaling and stress-intolerance in aged murine and human myocardium.Exp Gerontol | W probówce | 2014 |
| Rapamycin induces pluripotent genes associated with avoidance of replicative senescence.Cell Cycle | W probówce | 2013 |
| Autophagy and apoptosis of recombinant Chinese hamster ovary cells during fed-batch culture: effect of nutrient supplementation.Biotechnol Bioeng | W probówce | 2011 |
| Hyperactive S6K1 mediates oxidative stress and endothelial dysfunction in aging: inhibition by resveratrol.PLoS One | W probówce | 2011 |
| Autophagy impairment induces premature senescence in primary human fibroblasts.PLoS One | W probówce | 2011 |
| Acetaminophen improves protein translational signaling in aged skeletal muscle.Rejuvenation Res | W probówce | 2010 |
| Monitoring mammalian target of rapamycin (mTOR) activity.Methods Enzymol | W probówce | 2009 |
| Aging increases pulmonary veins arrhythmogenesis and susceptibility to calcium regulation agents.Heart Rhythm | W probówce | 2007 |
| Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in Ames dwarf mice.J Gerontol A Biol Sci Med Sci | W probówce | 2005 |
| Rapamycin attenuates age-related atrial remodeling and fibrillation by targeting HIF-1α-mediated metabolic dysregulation.Biochim Biophys Acta Mol Basis Dis | Inna praca | 2027 |
| Survey of the human proteostasis network: the autophagy-lysosome pathway.Autophagy | Inna praca | 2026 |
| Ginsenoside Rb1 alleviates uterine aging via AMPK-mediated mTOR inactivation.Signal Transduct Target Ther | Inna praca | 2026 |
| Human serum collected after fermented whey protein supplementation stimulates myocellular growth and protein synthesis: A randomized, double-blind, active-controlled crossover trial.Exp Gerontol | Inna praca | 2026 |
| S-adenosyl-L-homocysteine triggers an adaptive response that extends lifespan through the YBT1 ABC transporter.Proc Natl Acad Sci U S A | Inna praca | 2026 |
| Senescent cardiac cells promote thrombus formation and impair fibrinolysis.Geroscience | Inna praca | 2026 |
| Feedback loops between DNMT1 and autophagy as well as senescence promotes organ aging and canities.Autophagy | Inna praca | 2026 |
| Tissue-specific aging clocks map structured aging-modulatory drug-score patterns across 49 human tissue and cell-line categories.Biogerontology | Inna praca | 2026 |
| Retrotransposable element derepression distinguishes DNMT3A-mutant from TET2-mutant clonal haematopoiesis.Geroscience | Inna praca | 2026 |
| Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK.Signal Transduct Target Ther | Inna praca | 2026 |
| Caenorhabditis Intervention Testing Program: the putative mTOR inhibitors Cinnarizine and Meclizine do not extend lifespan in C. elegans.MicroPubl Biol | Inna praca | 2026 |
| Silibinin ameliorated lipid accumulation through insulin/IGF-1 signaling pathway in HGI Caenorhabditis elegans.J Nutr Biochem | Inna praca | 2026 |
| Rapamycin increases cerebral blood flow and modulates metabolic, inflammatory, and microbiome profiles in healthy middle-aged APOE4 carriers: A pilot single-arm trial.J Cereb Blood Flow Metab | Inna praca | 2026 |
| Activation of aryl hydrocarbon receptor by cigarette smoke induces oxidative stress, autophagy impairment and cellular senescence.Tob Induc Dis | Inna praca | 2026 |
| Copper and iron engage distinct metabolic programs for cellular survival.Geroscience | Inna praca | 2026 |
| mTOR drives cerebrovascular dysfunction and blood-brain barrier breakdown in a model of Alzheimers disease with cerebral amyloid angiopathy.bioRxiv | Inna praca | 2026 |
| Exercise-Induced Activation of IGF-1/mTOR Signaling and Hippocampal BDNF/PGC-1α Expression Reverses Age-Related Motor Decline.Int Neurourol J | Inna praca | 2026 |
| Plasma as Proxy for Tissue Metabolism When Extending Lifespan in Mice.Metabolites | Inna praca | 2026 |
| Evaluation of Human Serum Albumin Nanoparticles for Rapamycin Delivery.ACS Omega | Inna praca | 2026 |
| Pseudomonas aeruginosa infection causes lysosomal dysfunction in the cystic fibrosis bronchial epithelium.Infect Immun | Inna praca | 2026 |
| Diet-dependent, beneficial and adverse effects of rapamycin on life span of Drosophila melanogaster.Geroscience | Inna praca | 2026 |
| A Systems Pharmacology Model of Aging Identifies Optimal Combination Therapies With Secondary Benefits on Weight Loss and Metabolic Health.CPT Pharmacometrics Syst Pharmacol | Inna praca | 2026 |
| Early life sugar rationing and ageing related diseases, biological ageing and mortality.Nat Commun | Inna praca | 2026 |
| Apelin-13 prevents GATA4-mediated neuronal senescence by restoring autophagy through mTORC1 inhibition.Cell Death Dis | Inna praca | 2026 |
| Autophagy-Related Gene-Set Signals in the Genetic Architecture of Obsessive-Compulsive Disorder: A Hypothesis-Generating Link to Nicotinamide Adenine Dinucleotide-Associated Cellular Maintenance Biology.Cureus | Inna praca | 2026 |
| SELENOT, a Key Membrane-Bound Selenoprotein, Mediates Selenium's Protection Against Lead-Induced Renal Aging in Chickens by Modulating Inflammation and Autophagy.Biology (Basel) | Inna praca | 2026 |
| The structure-activity relationship study of torkinib derivatives as mTOR inhibitors with senolytic and STAT3 inhibitory activities.Bioorg Chem | Inna praca | 2026 |
| Multi-Tissue Metabolomic Signatures of Five Longevity Interventions Converge on Ergothioneine and Lipid Remodeling in Male UM-HET3 Mice.bioRxiv | Inna praca | 2026 |
| Inhibitory effect of standardized Kaempferia parviflora extract on sarcopenia by improving protein metabolism pathways in aged C57BL/6J mice.J Tradit Complement Med | Inna praca | 2026 |
| Dementia, mood disorders, and aging: Bridging new avenues of care through shared biological pathways.Aging Adv | Inna praca | 2026 |
| An aging hallmark, Alzheimer's disease, and APOE nexus.J Alzheimers Dis | Inna praca | 2026 |
| Limonin mitigates hepatic senescence and fibrosis in MASH mice by targeting STAT3 to inhibit Galectin-3/mTORC1 signaling.Phytomedicine | Inna praca | 2026 |
| Matrix stiffness disrupts tight junction integrity in retinal pigment epithelial cells via YAP1-mediated autophagy suppression.Exp Cell Res | Inna praca | 2026 |
| Mammalian aging involves genome-wide splicing degeneration leading to functional decline.bioRxiv | Inna praca | 2026 |
| Chondroprotective Effects of Enzyme-Treated Extract from Cervus elaphus L. in a Rat Model of Osteoarthritis.Int J Mol Sci | Inna praca | 2026 |
| Time-Restricted Feeding/Eating and Muscle Aging: Research Progress from Molecular Mechanisms to Personalized Intervention Strategies.Nutr Rev | Inna praca | 2026 |
| YIF1A activates mTORC1 signaling to promote cellular senescence.Cell Death Dis | Inna praca | 2026 |
| Rapamycin Attenuates Age-Related Changes in Marmoset Submandibular Gland: A Non-Human Primate Model of Human Oral Aging.Aging Dis | Inna praca | 2026 |
| Opposing Ageing-Related Transcriptomic Profiles Distinguish Opioid Exposure Liability From Dependence Liability.Cureus | Inna praca | 2026 |
| Dark side of glial talk: Role of neuroinflammation in neurodegeneration.Neural Regen Res | Inna praca | 2026 |
| Geroprotective interventions preserve trabecular bone during ageing in female mice.bioRxiv | Inna praca | 2026 |
| Integrating evolutionary theory into a framework for the mechanistic evaluation of candidate anti-aging interventions.Front Aging | Inna praca | 2026 |
| Combined leucine supplementation and exercise to counteract sarcopenia in patients with end-stage kidney disease undergoing maintenance hemodialysis: a single-center randomized pilot study.Kidney Res Clin Pract | Inna praca | 2026 |
| Interplay between cohesin and TORC1 links chromosome segregation and gene expression to environmental changes.Elife | Inna praca | 2026 |
| Short-term mTOR inhibition by rapamycin improves cardiac and endothelial function in older men: a proof-of concept pilot study.Geroscience | Inna praca | 2026 |
| Effect of Branched-Chain Amino Acid Supplementation Alone or Combined With Tryptophan or Methionine on Appetite Control and Related Health Outcomes in Older Adults: Protocol for a Randomized Controlled Trial.JMIR Res Protoc | Inna praca | 2026 |
| Type 2C protein phosphatases (PP2Cs) regulate cell proliferation in the yeast Saccharomyces cerevisiae.Mol Biol Rep | Inna praca | 2026 |
| Descriptive Analysis of Adverse Drug Events of Three mTOR Inhibitors Using WHO-VigiAccess.Curr Drug Saf | Inna praca | 2026 |
| Regulation of survival, growth, and metabolism by neuronal mTOR.Geroscience | Inna praca | 2026 |
| Fisetin Attenuates D-Gal-Induced Ovarian Aging by Modulating Mitophagy via the AMPK/mTOR Pathway.Antioxidants (Basel) | Inna praca | 2026 |
| Rapalink-1 Attenuates Oxidative-Stress-Induced Senescence in Vascular Cells in Association with Reduced NF-κB and MAPK Signaling.Biology (Basel) | Inna praca | 2026 |
| Transcriptomics analyses reveal microgravity triggers estrogen synthesis amidst degeneration and aging in human ovarian granulosa cells.Life Sci Space Res (Amst) | Inna praca | 2026 |
| Isoginkgetin protects against degeneration of ALS motor neurons via regulating the GSK-3β-TFEB signaling axis.Pharmacol Res | Inna praca | 2026 |
| Novel Rapamycin Derivative With Lower Immunosuppressive Activity and Cytotoxicity Extends Lifespan of Caenorhabditis elegans.J Appl Toxicol | Inna praca | 2026 |
| Smoke Condensate-Induced Vascular Senescence and SASP Are Attenuated by Dual mTORC1/2 Inhibition with Rapalink-1.Int J Mol Sci | Inna praca | 2026 |
| Sirolimus and Mimetics: Modulator Sine Qua Non for Cardiac Xenotransplantation?FASEB J | Inna praca | 2026 |
| A composite frailty index enables quantification of functional aging and identification of gerotherapeutic drugs in the house cricket.bioRxiv | Inna praca | 2026 |
| Female resistance to the metabolic benefits of protein restriction is reversed by ovariectomy in mice.bioRxiv | Inna praca | 2026 |
| Investigation of the Molecular Signature of Senescence in Mesenchymal Stem Cells.Avicenna J Med Biotechnol | Inna praca | 2026 |
| The Cheung Glutamatergic Regimen as a candidate for primary and secondary prevention of Alzheimer's disease onset.J Alzheimers Dis Rep | Inna praca | 2026 |