Graded
Ministerstwo zdrowia USA opublikowało projekt zasad, według którego nie będzie ścigać aptek przygotowujących BPC-157 na receptę dla konkretnej osoby, dopóki FDA nie zdecyduje w przepisach. To nadal nie jest dopuszczony lek.
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Safety and Metabolism-Related Outcomes of Oral Nicotinamide Mononucleotide Supplementation in Adults: A Systematic Review and Meta-Analysis.NutrientsAnaliza zbiorcza2026
Effects of Nicotinamide Mononucleotide Supplementation on Blood Pressure: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.NutrientsAnaliza zbiorcza2026
The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta-Analysis.J Cachexia Sarcopenia MuscleAnaliza zbiorcza2025
Effects of Nicotinamide Mononucleotide Supplementation on Muscle and Liver Functions Among the Middle-aged and Elderly: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Curr Pharm BiotechnolAnaliza zbiorcza2025
Efficacy of oral nicotinamide mononucleotide supplementation on glucose and lipid metabolism for adults: a systematic review with meta-analysis on randomized controlled trials.Crit Rev Food Sci NutrAnaliza zbiorcza2025
Effects of Nicotinamide Mononucleotide on Glucose and Lipid Metabolism in Adults: A Systematic Review and Meta-analysis of Randomised Controlled Trials.Curr Diab RepAnaliza zbiorcza2024
Exercise training upregulates intracellular nicotinamide phosphoribosyltransferase expression in humans: a systematic review with meta-analysis.Front Public HealthAnaliza zbiorcza2023
Anti-inflammatory effects of nicotinamide mononucleotide (NMN) in human skeletal muscle after BFR-exercise.J Int Soc Sports NutrZ losowaniem grup2026
Sublingual NMN administration increases early circulating terminal catabolites 2PY and 4PY compared with oral administration in healthy adult men.Sci RepZ losowaniem grup2026
Association between blood nicotinamide adenine dinucleotide levels and blood laboratory parameters at baseline and after nicotinamide mononucleotide supplementation in middle-aged healthy individuals: post hoc analysis of a randomized, double-blinded, placebo-controlled clinical trial.GeroscienceZ losowaniem grup2026
Effect of Nicotinamide Mononucleotide on Retinal Thickness of Older Patients With Diabetes Mellitus: A Placebo-Controlled, Double-Blind Study.Geriatr Gerontol IntZ losowaniem grup2026
The effects of pyrroloquinoline quinone and nicotinamide mononucleotide supplementation on interoception following acute exhaustive exercise: a randomised, double-blind, placebo-controlled study.Sci RepZ losowaniem grup2026
The differential impact of three different NAD+ boosters on circulatory NAD and microbial metabolism in humans.Nat MetabZ losowaniem grup2026
MIB-626, an Oral Formulation of a Microcrystalline Unique Polymorph of β-Nicotinamide Mononucleotide, Increases Circulating Nicotinamide Adenine Dinucleotide and its Metabolome in Middle-Aged and Older Adults.J Gerontol A Biol Sci Med SciZ losowaniem grup2023
Effects of nicotinamide mononucleotide on older patients with diabetes and impaired physical performance: A prospective, placebo-controlled, double-blind study.Geriatr Gerontol IntZ losowaniem grup2023
Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women.Sci RepZ losowaniem grup2022
Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study.NutrientsZ losowaniem grup2022
Nicotinamide mononucleotide supplementation enhances aerobic capacity in amateur runners: a randomized, double-blind study.J Int Soc Sports NutrZ losowaniem grup2021
Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span.J Med FoodZ losowaniem grup2020
Low-dose oral nicotinamide mononucleotide for immune thrombocytopenia: a phase 1/2 trial.Nat MedBez losowania grup2026
The acute effect of different NAD+ precursors included in the combined metabolic activators.Free Radic Biol MedBez losowania grup2023
Blood levels of nicotinic acid negatively correlate with hearing ability in healthy older men.BMC GeriatrBez losowania grup2023
Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men.Endocr JBez losowania grup2020
An open-label, non-randomized study of the pharmacokinetics of the nutritional supplement nicotinamide riboside (NR) and its effects on blood NAD+ levels in healthy volunteers.PLoS OneBez losowania grup2017
Leucocytes are a major source of circulating nicotinamide phosphoribosyltransferase (NAMPT)/pre-B cell colony (PBEF)/visfatin linking obesity and inflammation in humans.DiabetologiaBez losowania grup2011
Novel insight into nicotinamide adenine dinucleotide and related metabolites in cancer patients undergoing surgery.Sci RepObserwacja grupy2024
Exploring the therapeutic potential of β-nicotinamide mononucleotide (NMN) in regulating canine NT-proBNP levels.J Adv Vet Anim ResOpisy przypadków2026
NMNAT3 deficiency: a novel red blood cell enzymopathy causing hemolysis by altering NAD levels and glycolysis.BloodOpisy przypadków2025
New Insights on the Genetic Basis Underlying SHILCA Syndrome: Characterization of the NMNAT1 Pathological Alterations Due to Compound Heterozygous Mutations and Identification of a Novel Alternative Isoform.Int J Mol SciOpisy przypadków2021
Generation of a human induced pluripotent stem cell line from a patient with Leber congenital amaurosis.Stem Cell ResOpisy przypadków2020
Severe biallelic loss-of-function mutations in nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) in two fetuses with fetal akinesia deformation sequence.Exp NeurolOpisy przypadków2019
Clinical and genetic findings in a family with NMNAT1-associated Leber congenital amaurosis: case report and review of the literature.Graefes Arch Clin Exp OphthalmolOpisy przypadków2015
NMNAT1 mutations cause Leber congenital amaurosis.Nat GenetOpisy przypadków2012
Lysine Acetylation as a Regulatory Mechanism in Cardiometabolic Disease: A Focus on Sirtuins.Pharmaceuticals (Basel)Przegląd badań2026
NAD+ signaling in Parkinson's disease: molecular mechanisms and therapeutic perspectives.Front NeurolPrzegląd badań2026
Restoring NAD+ pathways in brain aging and neurodegenerative diseases: roles of vitamin B3 metabolites, gut microbiota, and exercise in cognitive health.Front NutrPrzegląd badań2026
Therapeutic Targeting of Inflammaging and Emerging Strategies for Managing Age-Related Multimorbidity: A Narrative Review.Clin Interv AgingPrzegląd badań2026
Narrative review of intravenous NAD+ and NAD+ precursors in wellness and translational medicine.Front AgingPrzegląd badań2026
Nicotinamide Mononucleotide Adenylyltransferase 1 and NAD+ Homeostasis in Neuroprotection and Aging.MetabolitesPrzegląd badań2026
SARM1 executes neuronal parthanatos and promotes excitotoxic cell death.NeuronPrzegląd badań2026
NAD⁺ biology and supplementation: From mechanisms to clinical perspectives.Mol Biol RepPrzegląd badań2026
Clinical and biochemical footprints of inherited cofactor disorders.Mol Genet MetabPrzegląd badań2026
Role of nicotinamide adenine dinucleotide in cardiovascular disease.Curr Opin CardiolPrzegląd badań2026
Exogenous Nucleotides as Functional Food Supplements: A Bibliometric Analysis of Global Research Trends (2000-2025).FoodsPrzegląd badań2026
Green manufacturing synthesis of nicotinamide mononucleotide: Pathways, catalysts, and prospects.Bioorg ChemPrzegląd badań2026
Sarcopenia and satellite cell homeostasis disruption: the dual function of NAD+ metabolism.Front NutrPrzegląd badań2026
An integrated anti-aging framework targeting NAD+ homeostasis, mitochondrial quality control, and redox stability: Roles of NMN/NR, PQQ, and EGT.Redox BiolPrzegląd badań2026
DLK, NMNAT2, and SARM1: Judge, Jury, and Executioner in Axon Degeneration.Annu Rev BiochemPrzegląd badań2026
DRP1 in reproduction and reproductive aging.Biol ReprodPrzegląd badań2026
Comparison of anti-aging effect of PQQ (Pyrroloquinoline quinone) and NMN/NR (Nicotinamide mononucleotide /Nicotinamide riboside) - possible combination use.Ageing Res RevPrzegląd badań2026
NMN supplementation as a strategy to improve oocyte quality: a systematic review and transcriptomic analysis.J Assist Reprod GenetPrzegląd badań2026
NAD+ precursors mitigate the in vitro and in vivo reproductive defects: Limitations and possible solutions.Reprod ToxicolPrzegląd badań2025
Preventive and Protective Effects of Nicotinamide Adenine Dinucleotide Boosters in Aging and Retinal Diseases.Int J Mol SciPrzegląd badań2025
The interplay of NAD+, hyperuricemia, and renal damage: A scientific review.Pathol Res PractPrzegląd badań2025
The Roles of Moonlighting Nicotinamide Mononucleotide Adenylyl Transferases in Cell Physiology.Int J Mol SciPrzegląd badań2025
Emerging strategies, applications and challenges of targeting NAD+ in the clinic.Nat AgingPrzegląd badań2025
Network of nicotinamide mononucleotide biosynthesis: substrate tracking, rate-limiting enzyme, and regulatory strategy.Synth Syst BiotechnolPrzegląd badań2025
Immunosenescence and cancer: molecular hallmarks, tumor microenvironment remodeling, and age-specific immunotherapy challenges.J Hematol OncolPrzegląd badań2025
Evaluation of the Role of PnuC Gene in Enhancing Nicotinamide Mononucleotide Synthesis.Biotechnol Appl BiochemPrzegląd badań2025
Biological production of nicotinamide mononucleotide: a review.Crit Rev BiotechnolPrzegląd badań2025
Nicotinamide and Pyridoxine in Muscle Aging: Nutritional Regulation of Redox, Inflammation, and Regeneration.Antioxidants (Basel)Przegląd badań2025
Biological properties, synthetic pathways and anti-aging mechanisms of nicotinamide mononucleotide (NMN): Research progress and challenges.BiogerontologyPrzegląd badań2025
Glycolytic Dysfunction in Granulosa Cells and Its Contribution to Metabolic Dysfunction in Polycystic Ovary Syndrome.Drug Des Devel TherPrzegląd badań2025
Nicotinamide Adenine Dinucleotide Supplementation to Alleviate Heart Failure: A Mitochondrial Dysfunction Perspective.NutrientsPrzegląd badań2025
Microbial Production of Nicotinamide Mononucleotide: Key Enzymes Discovery, Host Cells Selection, and Pathways Design and Optimization.ACS Synth BiolPrzegląd badań2025
NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control.NPJ AgingPrzegląd badań2025
Reactivating Circadian Rhythms as a Therapeutic Strategy: Insights from Basic Research.Biol Pharm BullPrzegląd badań2025
[Research progress on anti-aging effects of β-nicotinamide mononucleotide (NMN)].Sheng Li Xue BaoPrzegląd badań2024
Harnessing lactic acid bacteria for nicotinamide mononucleotide biosynthesis: a review of strategies and future directions.Front MicrobiolPrzegląd badań2024
An overview of engineering microbial production of nicotinamide mononucleotide.J BiotechnolPrzegląd badań2024
Function of NAD metabolism in white adipose tissue: lessons from mouse models.AdipocytePrzegląd badań2024
NAD+ enhancers as therapeutic agents in the cardiorenal axis.Cell Commun SignalPrzegląd badań2024
The function of nicotinamide phosphoribosyl transferase (NAMPT) and its role in diseases.Front Mol BiosciPrzegląd badań2024
The versatile multi-functional substance NMN: its unique characteristics, metabolic properties, pharmacodynamic effects, clinical trials, and diverse applications.Front PharmacolPrzegląd badań2024
Mitochondria as therapeutic targets in assisted reproduction.Hum ReprodPrzegląd badań2024
Regulation of and challenges in targeting NAD+ metabolism.Nat Rev Mol Cell BiolPrzegląd badań2024
Research advances in the function and anti-aging effects of nicotinamide mononucleotide.J Zhejiang Univ Sci BPrzegląd badań2024
Nicotinamide Mononucleotide: Research Process in Cardiovascular Diseases.Int J Mol SciPrzegląd badań2024
Advancements in NMN biotherapy and research updates in the field of digestive system diseases.J Transl MedPrzegląd badań2024
Improved Physical Performance Parameters in Patients Taking Nicotinamide Mononucleotide (NMN): A Systematic Review of Randomized Control Trials.CureusPrzegląd badań2024
Dual-targeted NAMPT inhibitors as a progressive strategy for cancer therapy.Bioorg ChemPrzegląd badań2024
Exploring nicotinamide adenine dinucleotide precursors across biosynthesis pathways: Unraveling their role in the ovary.FASEB JPrzegląd badań2024
Advances in the Synthesis and Physiological Metabolic Regulation of Nicotinamide Mononucleotide.NutrientsPrzegląd badań2024
Anti-aging effects of medicinal plants and their rapid screening using the nematode Caenorhabditis elegans.PhytomedicinePrzegląd badań2024
Ability of NAD and Sirt1 to epigenetically suppress albuminuria.Clin Exp NephrolPrzegląd badań2024
Nicotinamide Mononucleotide Supplementation: Understanding Metabolic Variability and Clinical Implications.MetabolitesPrzegląd badań2024
The therapeutic perspective of NAD+ precursors in age-related diseases.Biochem Biophys Res CommunPrzegląd badań2024
Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging.Aging DisPrzegląd badań2024
Metabolites in aging and aging-relevant diseases: Frailty, sarcopenia and cognitive decline.Geriatr Gerontol IntPrzegląd badań2024
Nicotinamide mononucleotide, a potential future treatment in ocular diseases.Graefes Arch Clin Exp OphthalmolPrzegląd badań2024
Biosynthesis of Nicotinamide Mononucleotide: Synthesis Method, Enzyme, and Biocatalytic System.J Agric Food ChemPrzegląd badań2024
The Role of NAD+ and NAD+-Boosting Therapies in Inflammatory Response by IL-13.Pharmaceuticals (Basel)Przegląd badań2024
Inhibitors of NAD+ Production in Cancer Treatment: State of the Art and Perspectives.Int J Mol SciPrzegląd badań2024
Human trials exploring anti-aging medicines.Cell MetabPrzegląd badań2024
Drug discovery targeting nicotinamide phosphoribosyltransferase (NAMPT): Updated progress and perspectives.Bioorg Med ChemPrzegląd badań2024
The Role of NMNAT2/SARM1 in Neuropathy Development.Biology (Basel)Przegląd badań2024
NAD+ Boosting Strategies.Subcell BiochemPrzegląd badań2024
Supplementation with NAD+ Precursors for Treating Alzheimer's Disease: A Metabolic Approach.J Alzheimers DisPrzegląd badań2024
Nicotinamide Mononucleotide in the Context of Myocardiocyte Longevity.Curr Aging SciPrzegląd badań2024
The concept of gene therapy for glaucoma: the dream that has not come true yet.Neural Regen ResPrzegląd badań2024
Glaucoma: neuroprotection with NAD-based therapeutic interventions.Trends Pharmacol SciPrzegląd badań2023
NAD+, Axonal Maintenance, and Neurological Disease.Antioxid Redox SignalPrzegląd badań2023
NAD+ Precursors in Human Health and Disease: Current Status and Future Prospects.Antioxid Redox SignalPrzegląd badań2023
Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions.J Gerontol A Biol Sci Med SciPrzegląd badań2023
Mechanism of initiation and regulation of axonal degeneration with special reference to NMNATs and Sarm1.Neurosci ResPrzegląd badań2023
The Molecular Mechanisms Involved in Axonal Degeneration and Retrograde Retinal Ganglion Cell Death.DNA Cell BiolPrzegląd badań2023
The Safety and Antiaging Effects of Nicotinamide Mononucleotide in Human Clinical Trials: an Update.Adv NutrPrzegląd badań2023
The Role of NAD+ in Metabolic Regulation of Adipose Tissue: Implications for Obesity-Induced Insulin Resistance.BiomedicinesPrzegląd badań2023
NAD+ Precursors Nicotinamide Mononucleotide (NMN) and Nicotinamide Riboside (NR): Potential Dietary Contribution to Health.Curr Nutr RepPrzegląd badań2023
Nicotinamide Riboside, a Promising Vitamin B3 Derivative for Healthy Aging and Longevity: Current Research and Perspectives.MoleculesPrzegląd badań2023
Technology and functional insights into the nicotinamide mononucleotide for human health.Appl Microbiol BiotechnolPrzegląd badań2023
[Advances in physiological activities and synthesis of β-nicotinamide mononucleotide].Sheng Wu Gong Cheng Xue BaoPrzegląd badań2023
NMNAT2: An important metabolic enzyme affecting the disease progression.Biomed PharmacotherPrzegląd badań2023
Potential Synergistic Supplementation of NAD+ Promoting Compounds as a Strategy for Increasing Healthspan.NutrientsPrzegląd badań2023
Importance of NAD+ Anabolism in Metabolic, Cardiovascular and Neurodegenerative Disorders.Drugs AgingPrzegląd badań2023
Mitochondrial Dysfunction and Therapeutic Perspectives in Cardiovascular Diseases.Int J Mol SciPrzegląd badań2022
Nutraceutical activation of Sirt1: a review.Open HeartPrzegląd badań2022
NAD+ Therapeutics and Skeletal Muscle Adaptation to Exercise in Humans.Sports MedPrzegląd badań2022
A Narrative Review of Nicotinamide Adenine Dinucleotide (NAD)+ Intermediates Nicotinamide Riboside and Nicotinamide Mononucleotide for Keratinocyte Carcinoma Risk Reduction.J Drugs DermatolPrzegląd badań2022
The role of nicotinamide mononucleotide (NMN) in anti-aging, longevity, and its potential for treating chronic conditions.Mol Biol RepPrzegląd badań2022
Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts.NutrientsPrzegląd badań2022
The chemical biology of NAD+ regulation in axon degeneration.Curr Opin Chem BiolPrzegląd badań2022
From Rate-Limiting Enzyme to Therapeutic Target: The Promise of NAMPT in Neurodegenerative Diseases.Front PharmacolPrzegląd badań2022
The key role of the NAD biosynthetic enzyme nicotinamide mononucleotide adenylyltransferase in regulating cell functions.IUBMB LifePrzegląd badań2022
SS-31, a Mitochondria-Targeting Peptide, Ameliorates Kidney Disease.Oxid Med Cell LongevPrzegląd badań2022
Bazi Bushen attenuates musculoskeletal degeneration in Ercc1+/- mice.Exp GerontolNa zwierzętach2026
Modulating hepatic hypoxanthine metabolism relieve metabolic stress-related neurovascular resilience disturbance via the liver-brain axis.Free Radic Biol MedNa zwierzętach2026
Nicotinamide Mononucleotide Does Not Prevent Cardiac Hypertrophy but Attenuates Cardiac Stress and Remodeling Markers in Mice Exposed to Intermittent Normobaric Hypoxia.NutrientsNa zwierzętach2026
PEGylated nicotinamide mononucleotide targeted ferroptosis in acute kidney injury by suppressing FAR1 palmitoylation in an ACAA1-dependent manner.Int J Biol SciNa zwierzętach2026
Macrophage-derived CD38 mediates colitis through NAD+ depletion.J PhysiolNa zwierzętach2026
Nicotinamide Mononucleotide Combined Glucose Counteracts Iron Overload-Induced Mitochondrial Dysfunction in Mice Under Hypobaric Hypoxia.Mol Cell ProteomicsNa zwierzętach2026
β-Nicotinamide mononucleotide reduces aflatoxin B1 induced liver injury via the gut microbiota-bile acid-farnesoid X receptor (FXR/NR1H4) axis.Br J PharmacolNa zwierzętach2026
Fetal hypoxia causes oocyte oxidative stress damage via the Sirt3/Sod2 pathway and can be alleviated by nicotinamide mononucleotide.Zool ResNa zwierzętach2026
Nicotinamide mononucleotide (NMN) improves the ovarian microenvironment associated with oocyte quality by increasing estrogen signaling, reprogramming ovarian metabolism, reducing oxidative stress, and inhibiting apoptosis in the spotted scat (Scatophagus argus).TheriogenologyNa zwierzętach2026
Nicotinamide mononucleotide alleviates the streptozotocin-mediated ferroptosis of islet β-cells via the Nrf2/GPX4 pathway.Braz J Med Biol ResNa zwierzętach2026
Nicotinamide Mononucleotide Ameliorates Myocardial Fibrosis in Diabetic Mice Possibly by Modulating SIRT3 to Deacetylate GSK3β and Thereby Reducing the Phosphorylation of Smad3.J Cardiovasc Transl ResNa zwierzętach2026
Investigation of the effects of nicotinamide mononucleotide on kidney damage in rats with cecal ligation and perforation sepsis model.Acta Cir BrasNa zwierzętach2026
Restorin® NR is a Highly Efficient NAD+ Precursor.Drug Des Devel TherNa zwierzętach2026
Real-Time Two-Photon Imaging of Brain Endothelial NAD+ Metabolism in Mice.J Vis ExpNa zwierzętach2026
Investigating the effects of nicotinamide mononucleotide administration on testicular apoptosis, and mitochondrial function in doxorubicin-treated rats.Mol Biol RepNa zwierzętach2026
Elamipretide (SS-31) and Nicotinamide Mononucleotide (NMN) Combination Therapy Targets TREM2 to Mitigate Post-ischemic Brain Injury in Mice.Neurochem ResNa zwierzętach2026
Comparative lipidomics and NAD⁺ metabolism in pectoris muscle reveal a lean metabolic phenotype in Daweishan miniature chickens versus arbor acre broilers.Poult SciNa zwierzętach2026
Iridoids from the edible flowers of Rhododendron pachypodum: structural elucidation and healthspan related bioactivities in Caenorhabditis elegans.PhytochemistryNa zwierzętach2026
Sleep-wake and circadian behavior in brain-specific sirtuin 1 knockout mice and effects of nicotinamide mononucleotide supplementation.Sci RepNa zwierzętach2026
Hepatic Hamp restoration contributes to nicotinamide mononucleotide (NMN)-alleviated hepatic steatosis in chronic alcohol-fed mice.Commun BiolNa zwierzętach2026
Nicotinamide Mononucleotide Ameliorates Nano-Aluminum Oxide-Induced Cognitive Impairment and Ferroptosis via the GSH/GPX4 Axis.SmallNa zwierzętach2026
Role of NMDAR-NMNAT in sevoflurane exposure-induced learning memory deficits.Brain DevNa zwierzętach2026
Nicotinamide Mononucleotide Reduces Iron in BV-2 Cell by Up-Regulating Ferroportin 1 via Inhibiting the IL-6/STAT3/Hepcidin Pathway.Rejuvenation ResNa zwierzętach2026
Nicotinamide Mononucleotide Improves High-Fat Diet-Induced Myocardial Damage of Aging Mice through the Sirt3/PINK1/Parkin Signaling Pathway.J NutrNa zwierzętach2026
Sirt1-eIF2α axis drives pro-inflammatory macrophage activation through ER stress aggravating liver IRI in aged mice.Biochem Biophys Res CommunNa zwierzętach2026
Stabilization of high internal phase emulsions by chitooligosaccharide‑sodium tripolyphosphate complexes: Application in enhancing stability and bioaccessibility of nicotinamide mononucleotide and Antarctic krill oil.Food ChemNa zwierzętach2026
SRN-901, a Novel Longevity Drug, Extends Lifespan and Healthspan by Targeting Multiple Aging Pathways.Drug Des Devel TherNa zwierzętach2026
NMN Can Restore Ovarian Reserve in Aged Mice by Upregulating NAD+/SIRT1/PGC-1α Signaling Pathway and TOMM20 Expression, and Improve in Vitro Development of Aging Oocytes.Reprod SciNa zwierzętach2026
Nicotinamide mononucleotide supplementation modulates gut microbiota and metabolites to mitigate Alzheimer's disease pathology in APP/PS1 mice.J Alzheimers DisNa zwierzętach2026
Circadian rhythm disruption impairs ovarian follicular development via NAD+ metabolic reprogramming.EBioMedicineNa zwierzętach2026
Uranium exposure induces osteopenia via mitochondrial dysfunction-driven senescence in bone marrow mesenchymal stem cells.J Hazard MaterNa zwierzętach2026
β-Nicotinamide mononucleotide preserves muscle strength in septic male mice.Sci RepNa zwierzętach2026
The combination of Anoectochilus roxburghii and Danggui-Niantong decoction ameliorates hyperuricemia by regulating NAD+ metabolism and urate transport in rats.PhytomedicineNa zwierzętach2026
Elastic cationic liposomal nanogels: a novel platform for topical nicotinamide mononucleotide delivery.J Liposome ResNa zwierzętach2026
NAD + -Boosting Ameliorates Heme Protein-Mediated Acute Kidney Injury.Kidney360Na zwierzętach2026
NMN/NAD+/SIRT1 axis activates NAMPT to ameliorate H2O2-triggered the impairment of progesterone synthesis in ovarian granulosa cells.J Ovarian ResNa zwierzętach2026
Reduced Versus Oxidized NAD+ Precursors Drive Distinct Transcriptomic, Proteomic, and Metabolic Profiles in Hepatocytes.FASEB JNa zwierzętach2026
Nicotinamide mononucleotide attenuates hyperandrogenism in a polycystic ovary syndrome-like rat model by suppressing NLRP3 inflammasome-mediated granulosa-cell pyroptosis.J Ovarian ResNa zwierzętach2026
β-Nicotinamide Mononucleotide protects against endotoxemia-induced myocardial injury through Sirt5-dependent desuccinylation of succinate dehydrogenase.Eur J PharmacolNa zwierzętach2026
Nicotinamide mononucleotide rescues perinatal arsenic-induced autism-like behaviours via modulation of NAD+ metabolism in mice.Ecotoxicol Environ SafNa zwierzętach2026
Beta-nicotinamide mononucleotide attenuates creatine kinase release in Duchenne muscular dystrophy model rats.J Vet Med SciNa zwierzętach2026
Nicotinamide mononucleotide improves spermatogenesis in aluminium-exposed mice by inhibiting NLRP3-mediated pyroptosis.PLoS OneNa zwierzętach2026
ERα activates NAMPT/IL-33 signaling to enhance beige thermogenesis and metabolic fitness.Sci AdvNa zwierzętach2026
NAD⁺ Reduction in Glutamatergic Neurons Induces Lipid Catabolism and Neuroinflammation in the Brain via SARM1.Adv Sci (Weinh)Na zwierzętach2026
The Mechanism of Action of NMN in Inhibiting NLRP3 Acetylation-Mediated Granulosa Cell Pyroptosis to Improve Ovarian Reserve Function in Ionizing Radiation-Exposed Mice.FASEB JNa zwierzętach2025
Sirtuins may mediate temperature-induced metabolic remodeling in threespine stickleback.J Comp Physiol BNa zwierzętach2025
Nicotinamide mononucleotide supplement combined with prolonging maturation time improves the quality of oocytes cultured in vitro.Anim Reprod SciNa zwierzętach2025
FOXO1-NMNAT3 axis dysregulation promotes doxorubicin cardiotoxicity: NAD+ replenishment as a redox-targeted antioxidant therapy.Redox RepNa zwierzętach2025
Protective effect of nicotinamide mononucleotide against soybean isoflavone induced damage in mouse testis.Reprod BiolNa zwierzętach2025
The m6A modification-mediated upregulation of ETS2 translation drives arsenic-induced spermatogonial senescence.Free Radic Biol MedNa zwierzętach2025
Nicotinamide mononucleotide treatment improves spermatogenesis in obese mice by reducing lysine acetylation of lactate dehydrogenase C.Commun BiolNa zwierzętach2025
Vascular Endothelial NAMPT-Mediated NAD+ Biosynthesis Regulates Angiogenesis and Cardiometabolic Functions in Male Mice.Aging CellNa zwierzętach2025
Mitochondrial dysfunction-associated cellular senescence is partially involved in bleomycin-induced pulmonary fibrosis in mice.Toxicol Appl PharmacolNa zwierzętach2025
Systemic nicotinamide mononucleotide administration to mitigate post-cardiac arrest brain injury in mice.PLoS OneNa zwierzętach2025
Effects of Nicotinamide Mononucleotide Supplementation and Aerobic Exercise on Metabolic Health and Physical Performance in Aged Mice.NutrientsNa zwierzętach2025
Single bolus injection of nicotinamide mono nucleotide increases systemic insulin sensitivity in association with activation of NAD salvage pathway in the liver and adipose tissue in mice.Endocr JNa zwierzętach2025
Neurometabolomic impacts of wood smoke and protective benefits of anti-aging therapeutics in aged female C57BL/6J mice.Part Fibre ToxicolNa zwierzętach2025
Sodium dehydroacetate induces porcine oocyte toxicity by inhibiting TCA cycle activity and mitochondrial function, with nicotinamide mononucleotide as a potential protective agent.Food Chem ToxicolNa zwierzętach2025
β-Nicotinamide mononucleotide protects against hypervirulent Klebsiella pneumoniae bloodstream infection and liver injury.mSphereNa zwierzętach2025
Beta-Hydroxybutyrate but not NMN supplementation mimics caloric restriction reducing early mortality in Daphnia.BiogerontologyNa zwierzętach2025
Biosensor-driven adaptive laboratory evolution and modular pathway engineering for high-level production of nicotinamide mononucleotide in yeast.Bioresour TechnolW probówce2026
Development of a noncanonical redox cofactor platform in Saccharomyces cerevisiae.Metab EngW probówce2026
Continuous production of nicotinamide mononucleotide by engineered Escherichia coli: effect of dilution rate and glucose feeding.Bioprocess Biosyst EngW probówce2026
Enhancing production of nicotinamide mononucleotide by metabolic engineering and flow cytometry screening of Escherichia coli.Biotechnol LettW probówce2025
NAD+-dependent Sirt6 is a key regulator involved in telomere shortening of in vitro-cultured preimplantation embryos.Commun BiolW probówce2025
Establishing a novel pathway for the biosynthesis of nicotinamide mononucleotide.Enzyme Microb TechnolW probówce2025
Enhancing nicotinamide mononucleotide production in Escherichia coli through systematic metabolic engineering.J BiotechnolW probówce2025
Nicotinamide Mononucleotide Production in Metabolically Engineered Saccharomyces cerevisiae.ACS Synth BiolW probówce2025
Metabolic reprogramming and machine learning-guided cofactor engineering to boost nicotinamide mononucleotide production in Escherichia coli.Bioresour TechnolW probówce2025
Improving Biosynthesis Efficiency of Nicotinamide Mononucleotide by ATP Recycling Engineering and Condition Optimization.J Agric Food ChemW probówce2025
Senescent alveolar type II epithelial cells-secreted GDF15 promotes silicosis progression via interfering intercellular communication.Ecotoxicol Environ SafW probówce2025
High-Level Production of Nicotinamide Mononucleotide by Engineered Escherichia Coli.J Agric Food ChemW probówce2024
De novo biosynthesis and nicotinamide biotransformation of nicotinamide mononucleotide by engineered yeast cells.Microb BiotechnolW probówce2024
Exploring the De Novo NMN Biosynthesis as an Alternative Pathway to Enhance NMN Production.ACS Synth BiolW probówce2024
Evaluation of NAD+ precursors for improved metabolism and productivity of antibody-producing CHO cell.Biotechnol JW probówce2024
Highly Bioadaptable Hybrid Conduits with Spatially Bidirectional Structure for Precision Nerve Fiber Regeneration via Gene Therapy.Adv Sci (Weinh)W probówce2024
A holistic approach for process intensification of nicotinamide mononucleotide production via high cell density cultivation under exponential feeding strategy.Bioresour TechnolW probówce2023
Nicotinamide mononucleotide (NMN) alleviates the poly(I:C)-induced inflammatory response in human primary cell cultures.Sci RepW probówce2023
Rapid prototyping enzyme homologs to improve titer of nicotinamide mononucleotide using a strategy combining cell-free protein synthesis with split GFP.Biotechnol BioengW probówce2023
Biotechnological production of reduced and oxidized NAD+ precursors.Food Res IntW probówce2023
Biosynthesis of a Therapeutically Important Nicotinamide Mononucleotide through a Phosphoribosyl Pyrophosphate Synthetase 1 and 2 Engineered Strain of Escherichia coli.ACS Synth BiolW probówce2021
Metabolic engineering of Escherichia coli for biosynthesis of β-nicotinamide mononucleotide from nicotinamide.Microb BiotechnolW probówce2021
Generation and assessment of high-quality mouse oocytes and embryos following nicotinamide mononucleotide administration.STAR ProtocW probówce2021
Synthesis of functional oligosaccharides and their derivatives through cocultivation and cellular NTP regeneration.Adv Appl MicrobiolW probówce2021
Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor.Microb Cell FactW probówce2020
Bacteroides-associated NAD⁺ depletion correlates with exacerbated radiation-induced colorectal injury and impaired mucosal proliferative capacity.Gut MicrobesInna praca2026
pH-responsive chitosan-based nanoparticles for targeted delivery of nicotinamide mononucleotide in acute kidney injury therapy.Colloids Surf B BiointerfacesInna praca2026
Dual-targeted pH-responsive nanoliposome (M5/NMN/DEAP/iRGD-Lip): Immunostimulatory-photodynamic synergy for breast cancer therapy.Colloids Surf B BiointerfacesInna praca2026
A senescent metabolism-modulating hierarchical scaffold restores NAD+ homeostasis and redox balance for aged bone repair.Bioact MaterInna praca2026
NAD+ precursor supplementation reverses CD36-mediated lipid accumulation and ferroptosis to restore antitumor function of NK cells in DLBCL.Pharm Sci AdvInna praca2026
Hepatoprotective Effect of Nicotinamide Mononucleotide on High-Fat Diet-Induced Non-Alcoholic Fatty Liver Disease in Mice.Food Sci NutrInna praca2026
Local inhibition of glaucomatous mitochondrial dysfunction using an engineered annular sector microneedle.BiomaterialsInna praca2026
Nuclear NAD+ promotes innate immune memory by inhibiting KDM5A-dependent histone demethylation.Sci ImmunolInna praca2026
Revealing NMN-induced biomacromolecular complex and conformational regulation of digestive enzymes (Trypsin, Pepsin, α-Amylase): Insights from molecular dynamics simulation and multi-spectroscopy.Biochem PharmacolInna praca2026
NMN Ameliorates STXBP1-R292C Variant-mediated Developmental and Motor Dysfunction: Molecular Docking and Functional Studies.J Mol NeurosciInna praca2026
Nicotinamide Mononucleotide Is Associated with Attenuation of OGD/R-Induced Pro-Inflammatory Programs in Microglia: Transcriptomic Evidence Converging on the NLRP3 Inflammasome and Lipid-Droplet-Related Molecular Signatures.BiomedicinesInna praca2026
Nicotinamide mononucleotide supplementation improves polycystic ovary syndrome by activating silent regulatory protein 2 mediated lactate dehydrogenase A lysine 119 deacetylation to enhance glycolytic activity.Int J Biol MacromolInna praca2026
Smpd2 m6A modification contributes to hypoxic pulmonary hypertension via an alveolar epithelial cell senescence-associated phenotype.Tissue CellInna praca2026
Platelet-derived microparticles induce CD8+ T cell senescence in chronic kidney disease via the transfer of microRNA-550a-5p.Exp Mol MedInna praca2026
Nicotinamide Mononucleotide-Producing Probiotic Strain B12-N Attenuates Aging and Cognitive Decline in a Caenorhabditis elegans Model of Alzheimer's Disease: Efficacy and Underlying Mechanisms.FoodsInna praca2026
Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging.Adv Sci (Weinh)Inna praca2026
Nicotinamide mononucleotide supports the development of bovine embryo through enhancement of mitochondrial function in morula.ReproductionInna praca2026
Reversal of Chronic Stress-Induced Inflammaging by Bazi Bushen Formula Through AMPK-Sirtuins Axis Activation and Myeloid Reset.Exploration (Beijing)Inna praca2026
Purine availability determines survival of complex I-deficient fibroblasts under OXPHOS-reliant condition.MitochondrionInna praca2026
Semi-Rational Design of CpNampt Mutants for Enhanced Nicotinamide Mononucleotide (NMN) Synthesis in Saccharomyces cerevisiae.Microb PhysiolInna praca2026
Magnesium Phosphate Composite Hydrogel Dressing Promotes Diabetic Wound Repair Through Anti-Inflammatory, Antioxidant, Angiogenic, and Metabolic Regulatory Mechanisms.Adv Healthc MaterInna praca2026
Nicotinamide Adenine Dinucleotide Augmentation in Diabetic Kidney Disease: Randomized Trial Study Protocol.Kidney Int RepInna praca2026
Enhancing the anti-ageing capacity of hUC-MSCs via NMN co-treatment in D-galactose-induced ageing mice and cellular senescence models.Mech Ageing DevInna praca2026
PROMETHEUS clinical trial protocol: tailoring healthy ageing with lifestyle and nutraceuticals.GeroscienceInna praca2026
NMN/NAD+ enhances SIRT2-modulated microtubule dynamics to improve mitochondrial and mitophagy functions in senescent cells.AutophagyInna praca2026
A potential anti-aging probiotic: Lactobacillus paracasei JS-3 extends lifespan in Caenorhabditis elegans and modulates the gut microbiota in the elderly.J Nutr BiochemInna praca2026
Bioactive chitosaan-nicotinamide mononucleotide-naringin composite scaffolds for enhanced maxillofacial bone regeneration.J Biomater ApplInna praca2026
Enhanced Sensitivity and Human Relevance: a TNF-α-Induced HaCaT Keratinocyte Model for Screening Anti-Inflammatory Cosmetic Materials.J Appl ToxicolInna praca2026
OsEPSPS Balances Disease Resistance and Plant Growth.Plant Cell EnvironInna praca2026
Regulation-Metabolism Rewiring Enables Efficient Nicotinamide Mononucleotide Biosynthesis in Food-Grade Lactiplantibacillus plantarum.J Agric Food ChemInna praca2026
β-Nicotinamide Mononucleotide Inhibits Cellular Senescence in Mouse C2C12 Skeletal Muscle Cells.J Aging ResInna praca2026
Endothelial C/EBPβ/AEP pathway drives vascular deterioration and systemic aging.Sci AdvInna praca2026
NMN mitigates LPS-induced liver injury by inhibiting ferroptosis via suppression of the cGAS-STING-ACSL4 axis.Pharmacol ResInna praca2026
Reprogramming the Rossmann fold signature motif creates orthogonal redox biocatalysts.Nat CommunInna praca2026
Engineered mesenchymal stem cells regulate integrated stress response for fibrosis therapy.MedInna praca2026
A sequence motif enables widespread use of noncanonical redox cofactors in natural enzymes.Nat Chem BiolInna praca2026
NAD+ metabolism influences TGF-β-associated transcriptional programs and the gut microbiota in murine models of colitis.Biochem Biophys RepInna praca2026
Nicotinamide Mononucleotide Adenylyltransferase 2 (NMNAT2) - Related Polyneuropathy - An Unusual Symptom, and a Rare Disease.Neurol IndiaInna praca2026
Nicotinamide mononucleotide potentiates the anti-tumor efficacy of CAR-NK cell therapy targeting MSLN in ovarian cancer.Cancer Gene TherInna praca2026
Mitochondrial-impaired ductal epithelium fuels TLS formation in Sjögren's disease.Ann Rheum DisInna praca2026
Metabolic Engineering of Pseudomonas putida KT2440 for β-Nicotinamide Mononucleotide Biosynthesis from Glucose and Aspartate.MicroorganismsInna praca2026
A Staged Translational Framework for Evaluating Oral Glutamatergic and Senescence-Modulating Strategies in Treatment-Resistant Depression.Drug Des Devel TherInna praca2026
Nicotinamide Mononucleotide (NMN) Prevents Age-Associated Transcriptional Drift in a Tissue-Dependent Manner: Mechanistic Leads From Ras-Related Protein Rab-11A-Mediated Trafficking and Carnitine Palmitoyltransferase 2-Linked Fatty Acid Oxidation.CureusInna praca2026
New mechanistic insight into SARM1 activation: TRIM32-mediated ubiquitination is a key lever that actuates SARM1's catalytic action, leading to axon degeneration and cell death.Front Neural CircuitsInna praca2026
A minimal three-arm oral regimen for healthspan: mechanistic alignment with transcriptomic signals from a large parental-lifespan GWAS.Front AgingInna praca2026
Nicotinamide Adenine Dinucleotide and Its Anti-aging Effects in the Context of Longevity and Menopause.Mini Rev Med ChemInna praca2026
Phage-encoded NARP3 system rebuilds NAD+ to subvert bacterial immunity.Sci AdvInna praca2026
Membrane-camouflaged liposomes Co-delivering L-Arg and NMN for reprogramming macrophage nitric oxide metabolism in atherosclerosis.J Biomater ApplInna praca2026
Senescence-associated metabolic alterations aggravate calcific aortic valve disease.Eur Heart JInna praca2026
Polycomb-Focused Transcriptome-Wide Association Study (TWAS) Reveals a Neuronal Identity, Circuit-Maintenance, and Cellular-Logistics Architecture Linking Anorexia Nervosa and Binge-Eating Behaviour.CureusInna praca2026
The impact of nicotinamide mononucleotide on ovarian health: A comprehensive literature review of preclinical evidence and therapeutic potential.Clin Exp Reprod MedInna praca2026
Nicotinamide Mononucleotide Attenuates Inflammatory Activation, Choroidal Neovascularization, and Lesion-Associated Remodeling.Invest Ophthalmol Vis SciInna praca2026
A combined artificial intelligence-wet lab approach identifies a pivotal role of the NAD+-mitophagy axis on aging and neurodegeneration.Alzheimers DementInna praca2026
SIRT1 deacetylates PKM2 to constrain lactate production and protect against premature ovarian insufficiency.Life MedInna praca2026
AIE-pharmacology: Acacetin and NMN co-delivery rescues sperm motility.Mater Today BioInna praca2026
Cellular Logistics and Synaptic Vesicle Vulnerability in Major Depressive Disorder and Amyotrophic Lateral Sclerosis Comorbidity: Insights From Nicotinamide Mononucleotide Rescue and Transcriptome-Wide Association Study Integration.CureusInna praca2026
NMN alleviates oxidative stress damage in alopecia areata by activating SIRT7 and promoting glutamine metabolism.Biochim Biophys Acta Gene Regul MechInna praca2026
Autophagy-Related Gene-Set Signals in the Genetic Architecture of Obsessive-Compulsive Disorder: A Hypothesis-Generating Link to Nicotinamide Adenine Dinucleotide-Associated Cellular Maintenance Biology.CureusInna praca2026
Dual compartment lipid carriers hijack exocytosis to empower natural killer cells against solid tumours.Nat CommunInna praca2026
CPT2 as a Convergent Node Linking Age-Associated Neuronal H3K27me3 Remodeling to Nicotinamide Mononucleotide (NMN)-Induced Expression Rescue in Metabolic Tissues.CureusInna praca2026

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Zarejestrowane badania na ludziach (30)

BadaniaEtapStatusLiczba uczestnikówAktualizacja
Evaluate the Safety, Tolerability, and Efficacy of UthPeak NMNH (Reduced β-Nicotinamide Mononucleotide Calcium Salt) in Healthy Adult Participants–Zakończone802026-10-27
Effects of Trigonelline Monohydrate on NAD+ Metabolism, Pharmacokinetics, Safety, and Tolerability in Healthy AdultsEtap 1Jeszcze nie ruszyło602026-10-19
Nicotinamide Mononucleotide Supplementation for Exercise Tolerance Improvement in Healthy Older Adults–Szuka uczestników402026-10-07
Nicotinamide Mononucleotide in Patients Undergoing Cardiac SurgeryEtap 2Szuka uczestników902026-09-21
Effect of NMN Supplementation on Organ System Biology–Zakończone562026-09-10
Assessing the Safety and Tolerability of NMN in DHDDS-CDGEtap 1Szuka uczestników82026-06-22
Intervention of Nicotinamide Mononucleotide in Middle-aged and Elderly People–Szuka uczestników2402026-05-08
PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)–Szuka uczestników202026-03-05
Effects of MIB-626 With and Without A High-Intensity Multi-Dimensional Exercise Training ProgramEtap 2Zakończone1242026-01-21
Effect of NMN (Nicotinamide Mononucleotide) on Polycystic Ovary Syndrome–Zakończone882025-11-25
A Clinical Study of NAD in the Treatment of Immune ThrombocytopeniaEtap 1, Etap 2Szuka uczestników202025-08-05
The Impact of Nicotinamide Mononucleotide Sustained-release Tablets on Immunosenescence and Metablism in Middle-aged and Elderly Individuals With Metabolic Disorders.–Szuka uczestników1262025-07-08
Comparisons of NAD Precursors for Neuroenhancement in Glaucoma PatientsEtap 2Szuka uczestników1382025-06-26
Tracing the Metabolic Flux of Orally Administered NAD+ PrecursorsEtap 1Szuka uczestników322025-05-06
Metabolic Changes Induced by NMN in Healthy Subjects With Acute Binge DrinkEtap 1, Etap 2Zakończone222025-04-10
Impact of NMN Supplementation on CD4+ T Cell Recovery in HIV Patients With Immunological Failure–Jeszcze nie ruszyło72025-04-03
NAD-brain: a Pharmacokinetic Study of NAD Replenishment TherapyEtap 1Zakończone122025-01-17
Study to Evaluate the Effect of Nicotinamide Mononucleotide (NMN) As an Adjuvant to Standard of Care (SOC) On Fatigue Associated With COVID-19 Infection–Przerwane692024-09-23
The Effeciency of NMN in Improving IVF/ICSI-ET Pregnancy Outcomes in Patients With DOR–Szuka uczestników2002024-05-23
Preliminary Clinical Study of NMN Intervention in Mild Ulcerative Colitis–Nieznany482024-01-19
Effect of NMN on Muscle Recovery and Physical Capacity in Healthy Volunteers With Moderate Physical Activity–Zakończone1312024-01-17
The Exploratory Study on the Biological Function of Dendritic Cells In Vivo Supported by Nicotinamide Mononucleotide (Vital NAD)Wczesny etap 1Nieznany202023-09-13
The Exploratory Study on the Nicotinamide Mononucleotide (Vital NAD ) to Promote the Rejuvenation of the Peripheral Blood Immune Cells of Adults.Wczesny etap 1Nieznany102023-08-21
Safety and Pharmacokinetics of Nicotinamide Mononucleotide (NMN) in Healthy Adults.–Zakończone242023-03-30
Pharmacodynamics and Tolerance of Nicotinamide Mononucleotide (NMN, 400mg/Day) in Healthy Adults–Zakończone172023-01-26
Effect of NMN (Nicotinamide Mononucleotide) on Diminished Ovarian Reserve (Including Premature Ovarian Insufficiency)–Nieznany2002022-10-12
Nicotinamide Mononucleotide in Hypertensive PatientsEtap 4Nieznany202022-02-01
To Evaluate the Efficacy and Safety of NMN as an Anti-ageing Supplement in Middle Aged and Older (40-65 Years) Adults–Zakończone902021-10-01
Effect of "Nicotinamide Mononucleotide" (NMN) on Cardiometabolic Function–Zakończone252021-07-14
Evaluate the Efficacy and Safety of Uthever NMN(Nicotinamide Mononucleotide, a Form of Vitamin B3)–Zakończone662021-04-01