PT-141
bremelanotide · Vyleesi
A medicine approved in the US as Vyleesi for low sex drive in women before menopause. Not approved in the EU.
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- Type
- Acts on skin colour and libido
- Stage
- Approved medicine
- Safety
- Well known
- Risk of fakes
- Medium
- Checked
- Not yet
Safety. A US drug label for one use. It warns that blood pressure rises and pulse falls for a short time after each injection, and lists darker skin. Sources: US drug label.
Risk of fakes. The substance was found in samples seized by police. Nobody checked the contents against a label. Sources: study 1.
Is it legal
| Where | Status | Checked | |
|---|---|---|---|
| PL | No approval | The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. Source | Not yet |
| EU | No approval | The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). Source | Not yet |
| US | Prescription only | Prescription medicine (Vyleesi). Source | Not yet |
How much research exists
Scientific papers per year 2015–2025
These are search results. A count shows how much exists, not how good the studies are. 1 Nov 2026.
Reported side effects
What doctors, patients and companies reported to the US medicines agency (FDA), and single cases described in medical journals. A report says what happened to someone after taking the substance. It does not prove the substance caused it, and it does not say how often it happens. Reports do not change any grade.
Reports to the FDA (USA)
- Reports
- 1,151
- Of these, serious
- 35
| Most often reported | Reports |
|---|---|
| Nausea | 494 |
| Headache | 170 |
| Vomiting | 127 |
| Flushing | 83 |
| Dizziness | 51 |
| Feeling unwell or strange | 50 |
| Tiredness | 48 |
| Feeling generally unwell | 43 |
Serious means the person went to hospital, their life was in danger, they were left with lasting harm, or they died. One report can list several side effects. Most of these reports come from medical treatment, often of people who are ill, not from use outside medicine.
Cases described in medical journals
FDA reports come from openFDA, cases from a PubMed search. The editors have not read these cases yet. Titles stay in the original language. As of 3 Nov 2026.
More papers we found
We found these papers automatically in PubMed. The editors have not read them yet, and they do not affect any grade. Titles stay in the original language.
Short answers
- Does PT-141 work?
- A medicine approved in the US as Vyleesi for low sex drive in women before menopause. Not approved in the EU. We have not graded the studies yet. The number of papers in the databases is shown on the page.
- Is PT-141 legal?
- PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). US: Prescription only. Prescription medicine (Vyleesi).
- Is PT-141 banned in sport?
- Not on the list, WADA 2026.
- Is PT-141 safe?
- Well known. A US drug label for one use. It warns that blood pressure rises and pulse falls for a short time after each injection, and lists darker skin.