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The US health department published a draft policy under which it would not act against pharmacies that make BPC-157 on a prescription for a named patient, until the FDA decides by rule. It is still not an approved medicine.
PL

LGD-4033

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Scientific papers

StudiesKind of studyYear
Drug transfer during intimate moments can produce an adverse analytical finding during a doping control: A case report with ligandrol.J Anal ToxicolCase reports2025
LGD-4033 and a Case of Drug-Induced Liver Injury: Exploring the Clinical Implications of Off-Label Selective Androgen Receptor Modulator Use in Healthy Adults.CureusCase reports2024
LGD-4033 and MK-677 use impacts body composition, circulating biomarkers, and skeletal muscle androgenic hormone and receptor content: A case report.Exp PhysiolCase reports2022
Multiple prohibited ingredients detected in nutritional supplements in a case of adverse analytical finding (AAF).Drug Test AnalCase reports2022
RAD-140 Drug-Induced Liver Injury.Ochsner JCase reports2022
Liver injury associated with the use of selective androgen receptor modulators and post-cycle therapy: Two case reports and literature review.World J Clin CasesCase reports2021
Drug-Induced Liver Injury Associated With Alpha Bolic (RAD-140) and Alpha Elite (RAD-140 and LGD-4033).ACG Case Rep JCase reports2020
Detection of SARMs in doping control analysis.Mol Cell EndocrinolReview of studies2018
Selective androgen receptor modulators for the prevention and treatment of muscle wasting associated with cancer.Curr Opin Support Palliat CareReview of studies2013
Protective role of harmol against β-cell toxicity and glucose dysregulation in type 2 diabetes mellitus.Eur J PharmacolIn animals2025
Ligandrol lowers endurance and negatively affects lipid and hormonal profile of male rats.Naunyn Schmiedebergs Arch PharmacolIn animals2025
Detection of LGD-4033 Metabolites in Camel Urine, Plasma, and Hair Following Oral Administration for Doping Control.Rapid Commun Mass SpectromIn animals2025
Ligandrol Ameliorates High-Fat Diet- and Streptozotocin-Induced Type 2 Diabetes Mellitus and Prevents Pancreatic Islets Degeneration.Assay Drug Dev TechnolIn animals2024
Investigations into the concentration and metabolite profiles of stanozolol and LGD-4033 in blood plasma and seminal fluid using liquid chromatography high-resolution mass spectrometry.Anal Bioanal ChemIn animals2023
Ostarine and Ligandrol Improve Muscle Tissue in an Ovariectomized Rat Model.Front Endocrinol (Lausanne)In animals2020
Development of a multi-residue high-throughput UHPLC-MS/MS method for routine monitoring of SARM compounds in equine and bovine blood.Drug Test AnalIn animals2020
Investigation of the metabolism of the selective androgen receptor modulator LGD-4033 in equine urine, plasma and hair following oral administration.Drug Test AnalIn animals2020
Quantification of the Carboxylated LGD-4033 Long-Term Metabolite in Human Micro-Dose Excretion Study Urine Samples.Drug Test AnalOther paper2026
Further Insights Into the Metabolism of LGD-4033 in Human Urine. Part 1. Structure Elucidation of Additional Important Metabolites.Drug Test AnalOther paper2026
Further Insights Into the Metabolism of LGD-4033 in Human Urine. Part 2. A New Minor Metabolite With Antagonistic Activity on the Androgen Receptor Can Indicate Recent Substance Intake.Drug Test AnalOther paper2026
Exploring transdermal SARMs exposure: analysis of the elimination profiles and metabolism for doping control purposes.J Anal ToxicolOther paper2025
SARMs, Metabolic Modulators and Growth Hormone Secretagogues in Suspected Illegal Medicines, Bought as Sport Performance Enhancers: A Retro- and Prospective Study Within the GEON.Drug Test AnalOther paper2025
In Vitro Metabolism of Doping Agents (Stanozolol, LGD-4033, Anastrozole, GW1516, Trimetazidine) by Human Seminal Vesicle and Liver Fractions.MetabolitesOther paper2025
Rapid detection of illegal selective androgen receptor modulators in unregistered supplements using a combination of selected solid-state analytical methods.ADMET DMPKOther paper2025
Detection of anabolic agents including selective androgen receptor modulators in samples outside of sport.Drug Test AnalOther paper2024
The disordering effect of SARMs on a biomembrane model.Phys Chem Chem PhysOther paper2024
Targeted Metabolic Investigation of Ligandrol and Analytical Methods Validation for Its Main Long-term Metabolite.ChempluschemOther paper2024
A screening method for the quantitative determination of selective androgen receptor modulators (SARMs) in capsules by high resolution 19F- and 1H-NMR spectroscopy.Anal MethodsOther paper2024
Investigation of in vitro generated metabolites of LGD-4033, a selective androgen receptor modulator, in homogenized camel liver for anti-doping applications.Rapid Commun Mass SpectromOther paper2023
Effects of ligandrol as a selective androgen receptor modulator in a rat model for osteoporosis.J Bone Miner MetabOther paper2023
Variation of Sequential Ligandrol (LGD-4033) Metabolite Levels in Routine Anti-Doping Urine Samples Detected with or without Other Xenobiotics.MoleculesOther paper2023
Selective Androgen Receptor Modulators Combined with Treadmill Exercise Have No Bone Benefit in Healthy Adult Rats.Pharmaceuticals (Basel)Other paper2023
Structure revision and chemical synthesis of ligandrol's main bishydroxylated long-term metabolic marker.Org Biomol ChemOther paper2022
Detection of selective androgen receptor modulators (SARMs) in serum using a molecularly imprinted nanoparticle surface plasmon resonance sensor.J Mater Chem BOther paper2022
The forensic response after an adverse analytical finding (doping) involving a selective androgen receptor modulator (SARM) in human athlete.J Pharm Biomed AnalOther paper2022
Investigations into the elimination profiles and metabolite ratios of micro-dosed selective androgen receptor modulator LGD-4033 for doping control purposes.Anal Bioanal ChemOther paper2022
Development and validation of SARMs and metabolic modulators screening in hair using UHPLC-MS/MS: Application to a doping case and first identification of S23 in authentic human hair.J Chromatogr B Analyt Technol Biomed Life SciOther paper2021
Perspectives in Evaluating Selective Androgen Receptor Modulators in Human Hair: A Short Communication.Ther Drug MonitOther paper2021
Simultaneous detection of different chemical classes of selective androgen receptor modulators in urine by liquid chromatography-mass spectrometry-based techniques.J Pharm Biomed AnalOther paper2021
High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction.Drug Test AnalOther paper2021
Human in vivo metabolism study of LGD-4033.Drug Test AnalOther paper2018
Equine in vivo-derived metabolites of the SARM LGD-4033 and comparison with human and fungal metabolites.J Chromatogr B Analyt Technol Biomed Life SciOther paper2018
In vitro metabolism study of a black market product containing SARM LGD-4033.Drug Test AnalOther paper2017
Characterization of a non-approved selective androgen receptor modulator drug candidate sold via the Internet and identification of in vitro generated phase-I metabolites for human sports drug testing.Rapid Commun Mass SpectromOther paper2015
Identification of black market products and potential doping agents in Germany 2010-2013.Eur J Clin PharmacolOther paper2014

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Registered studies in people (1)

StudiesStageStatusPeople taking partUpdated
Acute Hip Fracture Study in Patients 65 Years or GreaterStage 2Finished1082025-12-29