Graded
Ministerstwo zdrowia USA opublikowało projekt zasad, według którego nie będzie ścigać aptek przygotowujących BPC-157 na receptę dla konkretnej osoby, dopóki FDA nie zdecyduje w przepisach. To nadal nie jest dopuszczony lek.
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Melanotan 2

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Prace naukowe

BadaniaRodzaj badaniaRok
Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction.UrologyZ losowaniem grup2000
Melanocortin receptor agonists, penile erection, and sexual motivation: human studies with Melanotan II.Int J Impot ResBez losowania grup2000
Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study.J UrolBez losowania grup1998
Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study.Life SciBez losowania grup1996
A glimpse into the underground market of melanotan.Dermatol Online JObserwacja grupy2018
Changes in Oral Mucosa Associated with Melanotan II Injections: A Case Report.Life (Basel)Opisy przypadków2026
Melanotan II nasal spray: a possible risk factor for oral mucosal malignant melanoma?Int J Oral Maxillofac SurgOpisy przypadków2025
[The risks of tanning with the Barbie drug].Ned Tijdschr GeneeskdOpisy przypadków2022
Melanotan Tanning Injection: A Rare Cause of Priapism.Sex MedOpisy przypadków2021
Melanotan II: a possible cause of renal infarction: review of the literature and case report.CEN Case RepOpisy przypadków2020
[Eruptive nevi after injection of drugs marketed as melanotan II. The first two Swedish cases described].LakartidningenOpisy przypadków2013
[Dermoscopic changes in melanocytic nevi during use of melanotan II].HautarztOpisy przypadków2012
Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review.Sex Med RevPrzegląd badań2026
Falsification of biotechnology drugs: current dangers and/or future disasters?J Pharm Biomed AnalPrzegląd badań2018
Melanocortin receptor agonists in the treatment of male and female sexual dysfunctions: results from basic research and clinical studies.Expert Opin Investig DrugsPrzegląd badań2014
Recent advances in porous silicon technology for drug delivery.Ther DelivPrzegląd badań2013
Sympathetic and sensory innervation of brown adipose tissue.Int J Obes (Lond)Przegląd badań2010
Melanocortin peptide therapeutics: historical milestones, clinical studies and commercialization.PeptidesPrzegląd badań2006
Discovery that a melanocortin regulates sexual functions in male and female humans.PeptidesPrzegląd badań2005
Central nervous system agents in the treatment of erectile dysfunction: how do they work?Curr Urol RepPrzegląd badań2001
Antidepressant-like and antistress effects of the ACTH(4-10) synthetic analogs Semax and Melanotan II on male rats in a model of chronic unpredictable stress.Eur J PharmacolNa zwierzętach2024
Multiple metabolic signals in the CeA regulate feeding: The role of AMPK.Mol Cell EndocrinolNa zwierzętach2024
Therapeutic Strategies Against Metabolic Imbalance in a Male Mouse Model With 5-HT2CR Loss-of-Function.EndocrinologyNa zwierzętach2024
Melanotan-II reverses memory impairment induced by a short-term HF diet.Biomed PharmacotherNa zwierzętach2023
Melanocortin receptor agonist melanotan-II microinjected in the nucleus accumbens decreases appetitive and consumptive responding for food.NeuropeptidesNa zwierzętach2022
Intracerebroventricular administration of α-melanocyte-stimulating hormone (α-MSH) enhances thigmotaxis and induces anxiety-like behavior in the goldfish Carassius auratus.PeptidesNa zwierzętach2021
The Mesencephalic Trigeminal Nucleus Controls Food Intake and Body Weight via Hindbrain POMC Projections.NutrientsNa zwierzętach2021
Melanotan II, a melanocortin agonist, partially rescues the impaired thermogenic capacity of pituitary adenylate cyclase-activating polypeptide deficient mice.Exp PhysiolNa zwierzętach2021
Gqα/G11α deficiency in dorsomedial hypothalamus leads to obesity resulting from decreased energy expenditure and impaired sympathetic nerve activity.Am J Physiol Endocrinol MetabNa zwierzętach2021
CAPS2 deficiency induces proopiomelanocortin accumulation in pituitary and affects food intake behavior in mice.Neurosci LettNa zwierzętach2020
Combining MALDI mass spectrometry imaging and droplet-base surface sampling analysis for tissue distribution, metabolite profiling, and relative quantification of cyclic peptide melanotan II.Anal Chim ActaNa zwierzętach2020
Hypothalamic POMC deficiency increases circulating adiponectin despite obesity.Mol MetabNa zwierzętach2020
Melanocortin regulation of histaminergic neurons via perifornical lateral hypothalamic melanocortin 4 receptors.Mol MetabNa zwierzętach2020
Sites and sources of sympathoexcitation in obese male rats: role of brain insulin.Am J Physiol Regul Integr Comp PhysiolNa zwierzętach2020
Melanotan-II reverses autistic features in a maternal immune activation mouse model of autism.PLoS OneNa zwierzętach2019
Limiting feeding to the active phase reduces blood pressure without the necessity of caloric reduction or fat mass loss.Am J Physiol Regul Integr Comp PhysiolNa zwierzętach2018
Melanotan II causes hypothermia in mice by activation of mast cells and stimulation of histamine 1 receptors.Am J Physiol Endocrinol MetabNa zwierzętach2018
The stimulatory G protein Gsα is required in melanocortin 4 receptor-expressing cells for normal energy balance, thermogenesis, and glucose metabolism.J Biol ChemNa zwierzętach2018
Inherently Lean Rats Have Enhanced Activity and Skeletal Muscle Response to Central Melanocortin Receptors.Obesity (Silver Spring)Na zwierzętach2018
Control of appetite, blood glucose, and blood pressure during melanocortin-4 receptor activation in normoglycemic and diabetic NPY-deficient mice.Am J Physiol Regul Integr Comp PhysiolNa zwierzętach2018
Activation of the central melanocortin system in rats persistently reduces body and fat mass independently of caloric reduction.Can J Physiol PharmacolNa zwierzętach2018
AgRP-Expressing Adrenal Chromaffin Cells Are Involved in the Sympathetic Response to Fasting.EndocrinologyNa zwierzętach2017
Activation of the central melanocortin system chronically reduces body mass without the necessity of long-term caloric restriction.Can J Physiol PharmacolNa zwierzętach2017
Effect of Melanotan-II on Brain Fos Immunoreactivity and Oxytocin Neuronal Activity and Secretion in Rats.J NeuroendocrinolNa zwierzętach2017
Ventromedial hypothalamic melanocortin receptor activation: regulation of activity energy expenditure and skeletal muscle thermogenesis.J PhysiolNa zwierzętach2016
Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity.J Clin InvestNa zwierzętach2016
Lateral hypothalamic melanocortin receptor signaling modulates binge-like ethanol drinking in C57BL/6J mice.Addict BiolNa zwierzętach2016
Hypothalamic POMC Deficiency Improves Glucose Tolerance Despite Insulin Resistance by Increasing Glycosuria.DiabetesNa zwierzętach2016
[STUDYING THE ROLE OF BRAIN MELANOCORTIN RECEPTORS IN THE SUPPRESSING OF FOOD INTAKE UNDER ETHER STRESS IN MICE].Ross Fiziol Zh Im I M SechenovaNa zwierzętach2015
Temporal cAMP Signaling Selectivity by Natural and Synthetic MC4R Agonists.Mol EndocrinolNa zwierzętach2015
Role of the Paraventricular Nucleus of the Hypothalamus in the Sympathoexcitatory Effects of Leptin.HypertensionNa zwierzętach2015
Inconsistencies in the hypophagic action of intracerebroventricular insulin in mice.Physiol BehavNa zwierzętach2015
Defense of Elevated Body Weight Setpoint in Diet-Induced Obese Rats on Low Energy Diet Is Mediated by Loss of Melanocortin Sensitivity in the Paraventricular Hypothalamic Nucleus.PLoS OneNa zwierzętach2015
Evidence that Melanocortin Receptor Agonist Melanotan-II Synergistically Augments the Ability of Naltrexone to Blunt Binge-Like Ethanol Intake in Male C57BL/6J Mice.Alcohol Clin Exp ResNa zwierzętach2015
The oxytocin system promotes resilience to the effects of neonatal isolation on adult social attachment in female prairie voles.Transl PsychiatryNa zwierzętach2015
Melanocortin Receptor Agonists Facilitate Oxytocin-Dependent Partner Preference Formation in the Prairie Vole.NeuropsychopharmacologyNa zwierzętach2015
Analogue of Melanotan II (MTII): A Novel Melanotropin with Superpotent Action on Frog Skin.Protein Pept LettNa zwierzętach2015
Role of melanocortin signaling in neuroendocrine and metabolic actions of leptin in male rats with uncontrolled diabetes.EndocrinologyNa zwierzętach2014
Neonatal melanocortin receptor agonist treatment reduces play fighting and promotes adult attachment in prairie voles in a sex-dependent manner.NeuropharmacologyNa zwierzętach2014
Central vagal afferent endings mediate reduction of food intake by melanocortin-3/4 receptor agonist.J NeurosciNa zwierzętach2014
The PVH as a site of CB1-mediated stimulation of thermogenesis by MC4R agonism in male rats.EndocrinologyNa zwierzętach2014
The medial preoptic nucleus as a site of the thermogenic and metabolic actions of melanotan II in male rats.Am J Physiol Regul Integr Comp PhysiolNa zwierzętach2014
Pharmacological activation of the melanocortin system limits plaque inflammation and ameliorates vascular dysfunction in atherosclerotic mice.Arterioscler Thromb Vasc BiolNa zwierzętach2014
Central mechanisms of adiposity in adult female mice with androgen excess.Obesity (Silver Spring)Na zwierzętach2014
Pain reduces sexual motivation in female but not male mice.J NeurosciNa zwierzętach2014
The protective effects of the melanocortin receptor (MCR) agonist, melanotan-II (MTII), against binge-like ethanol drinking are facilitated by deletion of the MC3 receptor in mice.NeuropeptidesNa zwierzętach2014
Melanocortin 4 receptors in the paraventricular nucleus modulate the adipose afferent reflex in rat.PLoS OneNa zwierzętach2013
Adolescent binge-like ethanol exposure reduces basal α-MSH expression in the hypothalamus and the amygdala of adult rats.Pharmacol Biochem BehavNa zwierzętach2013
Melanocortin signaling in the brainstem influences vagal outflow to the stomach.J NeurosciNa zwierzętach2013
Melanocortin 3/4 receptors in paraventricular nucleus modulate sympathetic outflow and blood pressure.Exp PhysiolNa zwierzętach2013
Alterations in activity and energy expenditure contribute to lean phenotype in Fischer 344 rats lacking the cholecystokinin-1 receptor gene.Am J Physiol Regul Integr Comp PhysiolNa zwierzętach2012
Hemodynamic actions and mechanisms of systemically administered α-MSH analogs in mice.PeptidesNa zwierzętach2012
Food intake reductions and increases in energetic responses by hindbrain leptin and melanotan II are enhanced in mice with POMC-specific PTP1B deficiency.Am J Physiol Endocrinol MetabNa zwierzętach2012
Region-specific differences in brain melanocortin receptors in rats of the lean phenotype.NeuroreportNa zwierzętach2012
Melanocortin receptor 4 deficiency affects body weight regulation, grooming behavior, and substrate preference in the rat.Obesity (Silver Spring)Na zwierzętach2012
The anorectic effect of GLP-1 in rats is nutrient dependent.PLoS OneNa zwierzętach2012
CCK stimulation of GLP-1 neurons involves α1-adrenoceptor-mediated increase in glutamatergic synaptic inputs.DiabetesNa zwierzętach2011
Anatomical dissociation of melanocortin receptor agonist effects on taste- and gut-sensitive feeding processes.Am J Physiol Regul Integr Comp PhysiolNa zwierzętach2011
Characterization of a novel melanocortin receptor-containing node in the SNS outflow circuitry to brown adipose tissue involved in thermogenesis.Brain ResNa zwierzętach2011
Assessment of voluntary ethanol consumption and the effects of a melanocortin (MC) receptor agonist on ethanol intake in mutant C57BL/6J mice lacking the MC-4 receptor.Alcohol Clin Exp ResNa zwierzętach2011
Agouti-related peptide and MC3/4 receptor agonists both inhibit excitatory hypothalamic ventromedial nucleus neurons.J NeurosciW probówce2008
Presynaptic melanocortin-4 receptors on vagal afferent fibers modulate the excitability of rat nucleus tractus solitarius neurons.J NeurosciW probówce2008
Activation of central melanocortin receptors by MT-II increases cavernosal pressure in rabbits by the neuronal release of NO.Br J PharmacolW probówce2001
A comparison of HPLC and bioassay methods for plasma melanotan-II (MT-II) determination: application to a pharmacokinetic study in rats.Biopharm Drug DisposW probówce1994
Recommended Tool Compounds for the Melanocortin Receptor (MCR) G Protein-Coupled Receptors (GPCRs).ACS Pharmacol Transl SciInna praca2024
5-Hydroxypyrroloindoline Affords Tryptathionine and 2,2'-bis-Indole Peptide Staples: Application to Melanotan-II.ChemistryInna praca2024
Melanocortin agonism in a social context selectively activates nucleus accumbens in an oxytocin-dependent manner.NeuropharmacologyInna praca2024
Obesity medication lorcaserin activates brainstem GLP-1 neurons to reduce food intake and augments GLP-1 receptor agonist induced appetite suppression.Mol MetabInna praca2023
Vasopressin neurons in the paraventricular hypothalamus promote wakefulness via lateral hypothalamic orexin neurons.Curr BiolInna praca2022
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists.J Med ChemInna praca2022
A sentinel population: The public health benefits of monitoring enhanced body builders.Int J Drug PolicyInna praca2021
Zebrafish Bioassay for Screening Therapeutic Candidates Based on Melanotrophic Activity.Int J Mol SciInna praca2021
Depletion of Alpha-Melanocyte-Stimulating Hormone Induces Insatiable Appetite and Gains in Energy Reserves and Body Weight in Zebrafish.BiomedicinesInna praca2021
LC-HRMS characterization of the skin pigmentation and sexual enhancers melanotan II and bremelanotide sold on the black market of performance and image enhancing drugs.Drug Test AnalInna praca2021
Pharmacological chaperone action in humanized mouse models of MC4R-linked obesity.JCI InsightInna praca2021
Restoration of Cardiac Function After Myocardial Infarction by Long-Term Activation of the CNS Leptin-Melanocortin System.JACC Basic Transl SciInna praca2021
Melanotan II User Experience: A Qualitative Study of Online Discussion Forums.DermatologyInna praca2021
Development of Ligand-Drug Conjugates Targeting Melanoma through the Overexpressed Melanocortin 1 Receptor.ACS Pharmacol Transl SciInna praca2020
Application of Dimedone Enamines as Protecting Groups for Amines and Peptides.Org LettInna praca2020
Topical MTII Therapy Suppresses Melanoma Through PTEN Upregulation and Cyclooxygenase II Inhibition.Int J Mol SciInna praca2020
Glucose-regulated protein 78 binds to and regulates the melanocortin-4 receptor.Exp Mol MedInna praca2018
Operation resistance: A snapshot of falsified antibiotics and biopharmaceutical injectables in Europe.Drug Test AnalInna praca2016
Inhibitory Effect of the Melanocortin Receptor Agonist Melanotan-II (MTII) on Feeding Depends on Dietary Fat Content and not Obesity in Rats on Free-Choice Diets.Front Behav NeurosciInna praca2015
Melanocortin 4 receptor activation inhibits presynaptic N-type calcium channels in amygdaloid complex neurons.Eur J NeurosciInna praca2014
Neuroanatomy of melanocortin-4 receptor pathway in the lateral hypothalamic area.J Comp NeurolInna praca2012
Intermittent MTII application evokes repeated anorexia and robust fat and weight loss.PeptidesInna praca2010
I. Slow oscillations in vaginal blood flow: alterations during sexual arousal in rodents and humans.J Sex MedInna praca2010
Melanocortin-4 receptor activation inhibits c-Jun N-terminal kinase activity and promotes insulin signaling.PeptidesInna praca2009
Plasmon-waveguide resonance studies of ligand binding to integral proteins in membrane fragments derived from bacterial and mammalian cells.Anal BiochemInna praca2009
The first preparative solution phase synthesis of melanotan II.Beilstein J Org ChemInna praca2008
Interconnection between orexigenic neuropeptide Y- and anorexigenic alpha-melanocyte stimulating hormone-synthesizing neuronal systems of the human hypothalamus.Brain ResInna praca2006
Reduced anorexigenic efficacy of leptin, but not of the melanocortin receptor agonist melanotan-II, predicts diet-induced obesity in rats.EndocrinologyInna praca2005
Prevalence of mutations and functional analyses of melanocortin 4 receptor variants identified among 750 men with juvenile-onset obesity.J Clin Endocrinol MetabInna praca2005
Accelerating sensory recovery after sciatic nerve crush: non-selective versus melanocortin MC4 receptor-selective peptides.Eur J PharmacolInna praca2004
[Therapy of erectile dysfunction in 2005].Urologe AInna praca2003
Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat.Eur J PharmacolInna praca1999
American Urological Association--94th annual meeting. 1-6 May 1999, Dallas, USA.IDrugsInna praca1999

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Zarejestrowane badania na ludziach (1)

BadaniaEtapStatusLiczba uczestnikówAktualizacja
Melanotan II (MT-II) as an Adjunct to NB-UVB Phototherapy for Repigmentation in Stable Nonsegmental VitiligoEtap 2Szuka uczestników602026-02-27