Graded
The US health department published a draft policy under which it would not act against pharmacies that make BPC-157 on a prescription for a named patient, until the FDA decides by rule. It is still not an approved medicine.
PL

VIP

Back to the substance

Scientific papers

StudiesKind of studyYear
Inhaled Aviptadil Is a New Hope for Recovery of Lung Damage due to COVID-19.Med Princ PractRandom groups2025
Intravenous aviptadil and remdesivir for treatment of COVID-19-associated hypoxaemic respiratory failure in the USA (TESICO): a randomised, placebo-controlled trial.Lancet Respir MedRandom groups2023
Effect of intracanal medicaments on matrix metalloproteinase-9 and vasoactive intestinal peptide secretion in periapical lesions of re-treated canals: a randomized controlled clinical study.Clin Oral InvestigRandom groups2019
Comparative effect of electroacupuncture and moxibustion on the expression of substance P and vasoactive intestinal peptide in patients with irritable bowel syndrome.J Tradit Chin MedRandom groups2015
[Effects of electroacupuncture on plasma vasoactive intestinal peptide and substance P in perennial allergic rhinitis patients].Zhen Ci Yan JiuRandom groups2007
Effect of acupuncture on vasoactive intestinal peptide in ischemic cerebrovascular diseases.J Tradit Chin MedRandom groups1997
[The changes of vasoactive intestinal peptide somatostatin and pancreatic polypeptide in blood and CSF of acute cerebral infarction patients and the effect of acupuncture on them].Zhen Ci Yan JiuRandom groups1996
A clinical trial of intracavernous vasoactive intestinal peptide to induce penile erection.J UrolRandom groups1990
Effect of vasoactive intestinal peptide (VIP) on propranolol-induced bronchoconstriction.J Allergy Clin ImmunolRandom groups1988
The effect of inhaled vasoactive intestinal peptide on bronchial reactivity to histamine in humans.Am Rev Respir DisRandom groups1984
[Effects of highly selective branches neurotomy of vidian nerve with low temperature plasma on vasoactive intestinal peptide in nasal mucosal cells of patients with allergic rhinitis].Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za ZhiNo random groups2018
Prolonged treatment with transcutaneous electrical nerve stimulation (TENS) modulates neuro-gastric motility and plasma levels of vasoactive intestinal peptide (VIP), motilin and interleukin-6 (IL-6) in systemic sclerosis.Clin Exp RheumatolNo random groups2013
Inhaled vasoactive intestinal peptide exerts immunoregulatory effects in sarcoidosis.Am J Respir Crit Care MedNo random groups2010
Evidence for a role for vasoactive intestinal peptide in active vasodilatation in the cutaneous vasculature of humans.J PhysiolNo random groups2003
A suppressive effect of dexamethasone (DEX) on adrenocorticotropin (ACTH) response to vasoactive intestinal peptide (VIP) in Cushing's disease: a parallel modulation by DEX of ACTH responses to VIP and corticotropin-releasing hormone.NeuropeptidesNo random groups1997
Elcatonin raises levels of vasoactive intestinal peptide in human plasma.J Pharm PharmacolNo random groups1996
Vasoactive intestinal peptide-receptor imaging for the localization of intestinal adenocarcinomas and endocrine tumors.N Engl J MedNo random groups1994
Lack of involvement of the cholinergic mechanism in vasoactive intestinal peptide- and peptide-histidine methionine-induced growth hormone (GH) responses in acromegaly: comparison with the GH responses to thyrotropin-releasing hormone and GH-releasing hormone.NeuropeptidesNo random groups1994
Cholecystokinin, vasoactive intestinal peptide and peptide histidine methionine responses to feeding in anorexia nervosa.Regul PeptNo random groups1991
Paradoxical response of growth hormone to peptide histidine methionine in acromegaly: comparison with the effects of thyrotropin-releasing hormone and vasoactive intestinal peptide.J Clin Endocrinol MetabNo random groups1991
Effect of infused vasoactive intestinal peptide on airway function in normal subjects.ThoraxNo random groups1986
Vasoactive Intestinal Peptide (VIP)-Secreting Neuroblastic Tumors in Children Presenting With Chronic Secretory Diarrhea: A Report of Two Cases.CureusCase reports2026
Living Donor Liver Transplantation for Vasoactive Intestinal Peptide-Secreting Tumors with Watery Diarrhea, Hypokalemia, and Achlorhydria Syndrome Resulting from Transformation of a Nonfunctional Pancreatic Neuroendocrine Tumor with Multiple Liver Metastases: A Case Report.Surg Case RepCase reports2026
Successful liver transplantation as rescue therapy in a patient with metastases from a vasoactive intestinal peptide producing neuroendocrine tumor.J Surg Case RepCase reports2024
Aviptadil: A multifaceted approach to mitigating hypoxemia in acute respiratory distress syndrome.Respir Med Case RepCase reports2024
Pancreatic Vasoactive Intestinal Peptide-Producing Tumor as a Rare Cause of Acute Diarrhea and Severe Hypokalemia.J Med CasesCase reports2023
Vasoactive Intestinal Peptide Tumor as the Cause of Persistent Diarrhea: A Diagnostic Challenge.CureusCase reports2022
Brief Report: Rapid Clinical Recovery From Critical Coronavirus Disease 2019 With Respiratory Failure in a Pregnant Patient Treated With IV Vasoactive Intestinal Peptide.Crit Care ExplorCase reports2022
Case Report: Irreversible Watery Diarrhea, Severe Metabolic Acidosis, Hypokalemia and Achloridria Syndrome Related to Vasoactive Intestinal Peptide Secreting Malignant Pheochromocytoma.Front Endocrinol (Lausanne)Case reports2021
Rare Cases of Pediatric Vasoactive Intestinal Peptide Secreting Tumor With Literature Review: A Challenging Etiology of Chronic Diarrhea.Front PediatrCase reports2020
Octreotide reverses shock due to vasoactive intestinal peptide-secreting adrenal pheochromocytoma: A case report and review of literature.World J Clin CasesCase reports2018
Intractable and dramatic diarrhea in liver transplantation recipient with vasoactive intestinal peptide-producing tumor after split liver transplantation: a case report.Transplant ProcCase reports2015
Diagnosis and treatment of pancreatic vasoactive intestinal peptide endocrine tumors.PancreasCase reports2009
[Diagnosis and treatment of vasoactive intestinal peptide-secreting-tumors: one case report and 15 years review in China].Zhonghua Wai Ke Za ZhiCase reports2004
Pheochromocytoma producing vasoactive intestinal peptide.Mayo Clin ProcCase reports2002
Location of a VIPoma by iodine-123-vasoactive intestinal peptide scintigraphy.J Nucl MedCase reports1998
Elevated plasma levels of vasoactive intestinal peptide in AIDS patients with refractory idiopathic diarrhoea. Effects of treatment with octreotide.AIDSCase reports1993
Vasoactive intestinal peptide producing neuroblastoma.J Pediatr SurgCase reports1982
Intractable diarrhoea in a patient with vasoactive intestinal peptide-secreting neuroblastoma. Attempted control by somatostatin.Eur J PediatrCase reports1981
Streptozocin-treated Verner-Morrison Syndrome: plasma vasoactive intestinal peptide and tumor responses.Arch Intern MedCase reports1976
Aviptadil Therapy in Acute Respiratory Distress Syndrome Patients: A Systematic Review and Meta-analysis.Indian J Crit Care MedReview of studies2025
Vasoactive Intestinal Peptide-Producing Neuroblastic Tumors: A Rare Cause of Refractory Diarrhea.CureusReview of studies2024
A comprehensive history of injection therapy for erectile dysfunction, 1982-2023.Sex Med RevReview of studies2024
[Process in the role of vasoactive intestinal peptide in the treatment of ulcerative colitis by regulating the balance of T follicular helper cells/T follicular regulatory cells].Xi Bao Yu Fen Zi Mian Yi Xue Za ZhiReview of studies2024
The role of vasoactive intestinal peptide in pulmonary diseases.Life SciReview of studies2023
Vasoactive intestinal peptide: a potential target for antiviral therapy.Sheng Li Xue BaoReview of studies2022
Vasoactive intestinal peptide secreting tumour: An overview.World J Gastrointest OncolReview of studies2022
Anticipated pharmacological role of Aviptadil on COVID-19.Environ Sci Pollut Res IntReview of studies2022
Pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal peptide (Part 2): biology and clinical importance in central nervous system and inflammatory disorders.Curr Opin Endocrinol Diabetes ObesReview of studies2021
Pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal peptide [Part 1]: biology, pharmacology, and new insights into their cellular basis of action/signaling which are providing new therapeutic targets.Curr Opin Endocrinol Diabetes ObesReview of studies2021
Research advances of vasoactive intestinal peptide in the pathogenesis of ulcerative colitis by regulating interleukin-10 expression in regulatory B cells.World J GastroenterolReview of studies2020
Erectile dysfunction: a global review of intracavernosal injectables.World J UrolReview of studies2019
Advantages of Vasoactive Intestinal Peptide for the Future Treatment of Parkinson's Disease.Curr Pharm DesReview of studies2018
Role of vasoactive intestinal peptide in osteoarthritis.J Biomed SciReview of studies2016
Manganese-Enhanced Magnetic Resonance Imaging for Detection of Vasoactive Intestinal Peptide Receptor 2 Agonist Therapy in a Model of Parkinson's Disease.NeurotherapeuticsReview of studies2016
Vasoactive intestinal peptide/pituitary adenylate cyclase activating polypeptide, and their receptors and cancer.Curr Opin Endocrinol Diabetes ObesReview of studies2016
Novel Targets of Drug Treatment for Pulmonary Hypertension.Am J Cardiovasc DrugsReview of studies2015
Vasoactive intestinal peptide receptor-based imaging and treatment of tumors (Review).Int J OncolReview of studies2014
Prospect of vasoactive intestinal peptide therapy for COPD/PAH and asthma: a review.Respir ResReview of studies2011
Therapeutic potential of vasoactive intestinal peptide and its receptors in neurological disorders.CNS Neurol Disord Drug TargetsReview of studies2010
Pulmonary arterial hypertension: on the way to a manageable disease.Curr Opin Investig DrugsReview of studies2008
Structure-activity relationship of vasoactive intestinal peptide (VIP): potent agonists and potential clinical applications.Naunyn Schmiedebergs Arch PharmacolReview of studies2008
Vasoactive intestinal peptide as a healing mediator in Crohn's disease.NeuroimmunomodulationReview of studies2008
Emerging roles of vasoactive intestinal peptide: a new approach for autoimmune therapy.Ann Rheum DisReview of studies2007
Bioactive analogues and drug delivery systems of vasoactive intestinal peptide (VIP) for the treatment of asthma/COPD.PeptidesReview of studies2007
Vasoactive intestinal peptide receptors: a molecular target in breast and lung cancer.Curr Pharm DesReview of studies2007
Role of vasoactive intestinal peptide in inflammation and autoimmunity.Curr Opin Investig DrugsReview of studies2005
Vasoactive intestinal peptide family as a therapeutic target for Parkinson's disease.Expert Opin Ther TargetsReview of studies2005
Vasoactive intestinal peptide in the immune system: potential therapeutic role in inflammatory and autoimmune diseases.J Mol Med (Berl)Review of studies2002
Aviptadil (Senatek).Curr Opin Investig DrugsReview of studies2001
Vasoactive intestinal peptide regulates embryonic growth through the action of activity-dependent neurotrophic factor.Ann N Y Acad SciReview of studies1999
Identity of neurotrophic molecules released from astroglia by vasoactive intestinal peptide.Ann N Y Acad SciReview of studies1997
Design and development of a vasoactive intestinal peptide analog as a novel therapeutic for bronchial asthma.BiopolymersReview of studies1995
Vasoactive intestinal peptide in the hypothalamus and pituitary.NeuroendocrinologyReview of studies1991
Vasoactive intestinal peptide (VIP), a putative neurotransmitter of nonadrenergic, noncholinergic (NANC) inhibitory innervation and its relevance to therapy.J Vet Pharmacol TherReview of studies1989
Vasoactive intestinal peptide attenuates form-deprivation myopia in guinea pigs by suppressing the Wnt/β-catenin pathway along the retina-choroid-scleral axis.Exp Eye ResIn animals2026
Effects of vasoactive intestinal peptide on neuroexcitability of female-specific subpopulation of myelinated Ah-type neurons isolated from trigeminal ganglia of adult female rats.NeuropeptidesIn animals2026
Investigation of vasoactive intestinal peptide expression and significance in a congenital diaphragmatic hernia animal model.Pediatr Surg IntIn animals2025
Nanoparticle-Driven Tendon Repair: Role of Vasoactive Intestinal Peptide in Immune Modulation and Stem Cell Enhancement.ACS NanoIn animals2025
The role of vasoactive intestinal peptide (VIP) in atropine-related inhibition of the progression of myopia.BMC OphthalmolIn animals2024
Lactobacillus casei ATCC 393 combined with vasoactive intestinal peptide alleviates dextran sodium sulfate-induced ulcerative colitis in C57BL/6 mice via NF-κB and Nrf2 signaling pathways.Biomed PharmacotherIn animals2023
Vasoactive intestinal peptide exerts therapeutic action by regulating PTEN in a model of Sjögren's disease.Immun Inflamm DisIn animals2023
[Development of the vasoactive intestinal peptide receptor 2 (VIPR2) antagonist peptide for the treatment of schizophrenia].Nihon Yakurigaku ZasshiIn animals2023
Immunomodulatory effect of N-acetyl-seryl-aspartyl-proline and vasoactive intestinal peptide on chronic obstructive pulmonary disease pathophysiology.Fundam Clin PharmacolIn animals2022
Vasoactive Intestinal Peptide Indirectly Elicits Pituitary LH Secretion Independent of GnRH in Female Zebrafish.EndocrinologyIn animals2022
Vasoactive intestinal peptide attenuates bleomycin-induced murine pulmonary fibrosis by inhibiting epithelial-mesenchymal transition: Restoring autophagy in alveolar epithelial cells.Int ImmunopharmacolIn animals2021
Vasoactive intestinal peptide (VIP) conducts the neuronal activity during absence seizures: GABA seems to be the main mediator of VIP.Neurosci LettIn animals2021
Vasoactive Intestinal Peptide Promotes Fracture Healing in Sympathectomized Mice.Calcif Tissue IntIn animals2021
Alterations in the relative abundance of the vasoactive intestinal peptide receptors (VPAC1 and VPAC2) and functions in uterine contractility during inflammation.Anim Reprod SciIn animals2021
Colonic delivery of vasoactive intestinal peptide nanomedicine alleviates colitis and shows promise as an oral capsule.Nanomedicine (Lond)In animals2020
Function study of vasoactive intestinal peptide on chick embryonic bone development.NeuropeptidesIn animals2020
Vasoactive intestinal peptide infusion reverses existing renal interstitial fibrosis via a blood pressure independent mechanism in the rat.Eur J PharmacolIn animals2020
Vasoactive intestinal peptide regulates ileal goblet cell production in mice.Physiol RepIn animals2020
Shengui Sansheng Pulvis maintains blood-brain barrier integrity by vasoactive intestinal peptide after ischemic stroke.PhytomedicineIn animals2020
Vasoactive intestinal peptide suppresses the NLRP3 inflammasome activation in lipopolysaccharide-induced acute lung injury mice and macrophages.Biomed PharmacotherIn animals2020
Immunomodulation by vasoactive intestinal peptide is associated with increased survival and growth of Salmonella Typhimurium in mice.CytokineIn animals2020
[Effect of application of herbal medicine paste to "Tianshu" (ST25)on intestinal mobility and expression of vasoactive intestinal peptide and substance P in colonic myenteric plexus in rats with functional constipation].Zhen Ci Yan JiuIn animals2019
Vasoactive intestinal peptide decreases inflammation and tight junction disruption in experimental necrotizing enterocolitis.J Pediatr SurgIn animals2019
Vasoactive intestinal peptide ameliorates renal injury in a pristane-induced lupus mouse model by modulating Th17/Treg balance.BMC NephrolIn animals2019
Adrenalectomy impairs vasoactive intestinal peptide-induced changes in food intake and plasma parameters.EndocrineIn animals2019
Therapeutic effect of vasoactive intestinal peptide on form-deprived amblyopic kittens.BMC OphthalmolIn animals2019
Vasoactive intestinal peptide-induced tolerogenic dendritic cells attenuated arthritis in experimental collagen-induced arthritic mice.Int J Rheum DisIn animals2019
Vasoactive intestinal peptide inhibits the activation of murine fibroblasts and expression of interleukin 17 receptor C.Cell Biol IntIn animals2019
Vasoactive Intestinal Peptide Decreases β-Amyloid Accumulation and Prevents Brain Atrophy in the 5xFAD Mouse Model of Alzheimer's Disease.J Mol NeurosciIn animals2019
The effects of vasoactive intestinal peptide in the rat model of experimental autoimmune neuritis and the implications for treatment of acute inflammatory demyelinating polyradiculoneuropathy or Guillain-Barré syndrome.Drug Des Devel TherIn animals2018
Corticotrophin-releasing factor mediates vasoactive intestinal peptide-induced hypophagia and changes in plasma parameters.Horm BehavIn animals2018
Vasoactive Intestinal Peptide Ameliorates Acute Myocarditis and Atherosclerosis by Regulating Inflammatory and Autoimmune Responses.J ImmunolIn animals2018
Vasoactive intestinal peptide overexpression mediated by lentivirus attenuates lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammation.Mol ImmunolIn animals2018
Vasoactive intestinal peptide inhibits airway smooth muscle cell proliferation in a mouse model of asthma via the ERK1/2 signaling pathway.Exp Cell ResIn animals2018
Vasoactive intestinal peptide alleviates osteoarthritis effectively via inhibiting NF-κB signaling pathway.J Biomed SciIn animals2018
Respirable powder formulation of a shortened vasoactive intestinal peptide analog for treatment of airway inflammatory diseases.J Pept SciIn animals2018
Vasoactive Intestinal Peptide Protects Salivary Glands against Structural Injury and Secretory Dysfunction via IL-17A and AQP5 Regulation in a Model of Sjögren Syndrome.NeuroimmunomodulationIn animals2017
[Effect of vasoactive intestinal peptide on defecation and VIP-cAMP-PKA-AQP3 signaling pathway in rats with constipation].Zhong Nan Da Xue Xue Bao Yi Xue BanIn animals2016
Conjugated Alpha-Alumina nanoparticle with vasoactive intestinal peptide as a Nano-drug in treatment of allergic asthma in mice.Eur J PharmacolIn animals2016
Vasoactive intestinal peptide stimulates melanogenesis in B16F10 mouse melanoma cells via CREB/MITF/tyrosinase signaling.Biochem Biophys Res CommunIn animals2016
Modulation of Corpus Striatal Neurochemistry by Astrocytes and Vasoactive Intestinal Peptide (VIP) in Parkinsonian Rats.J Mol NeurosciIn animals2016
Vasoactive intestinal peptide promotes differentiation and clock gene expression in granulosa cells from prehierarchal follicles.Mol Reprod DevIn animals2016
In-Situ-Generated Vasoactive Intestinal Peptide Loaded Microspheres in Mussel-Inspired Polycaprolactone Nanosheets Creating Spatiotemporal Releasing Microenvironment to Promote Wound Healing and Angiogenesis.ACS Appl Mater InterfacesIn animals2016
Vasoactive intestinal peptide reduces the inflammatory profile in mice infected with Trypanosoma cruzi.Exp ParasitolIn animals2015
Vasoactive intestinal peptide administration after stroke in rats enhances neurogenesis and improves neurological function.Brain ResIn animals2015
Role of vasoactive intestinal peptide in the light input to the circadian system.Eur J NeurosciIn animals2015
Asymmetric steroidogenic response by the ovaries to the vasoactive intestinal peptide.EndocrineIn animals2015
Augmentation of the effects of vasoactive intestinal peptide aerosol on pulmonary hypertension via coapplication of a neutral endopeptidase 24.11 inhibitor.Am J Physiol Lung Cell Mol PhysiolIn animals2015
[effect of treatment from the lung and treatment from the intestine on vasoactive intestinal peptide contents of ulcerative colitis rats: a comparison study].Zhongguo Zhong Xi Yi Jie He Za ZhiIn animals2015
Endogenous inhibition of hippocampal LTD and depotentiation by vasoactive intestinal peptide VPAC1 receptors.HippocampusIn animals2014
Prevention of hyperoxia-induced bronchial hyperreactivity by sildenafil and vasoactive intestinal peptide: impact of preserved lung function and structure.Respir ResIn animals2014
Peripheral nerve reconstruction with epsilon-caprolactone conduits seeded with vasoactive intestinal peptide gene-transfected mesenchymal stem cells in a rat model.J Neural EngIn animals2014
Therapeutic efficacy of stable analogues of vasoactive intestinal peptide against pathogens.J Biol ChemIn animals2014
The effects of Fructus Aurantii extract on the 5-hydroxytryptamine and vasoactive intestinal peptide contents of the rat gastrointestinal tract.Pharm BiolIn animals2014
Vasodilatory effect of the stable vasoactive intestinal peptide analog RO 25-1553 in murine and rat lungs.PLoS OneIn animals2013
Vasoactive intestinal peptide attenuates liver ischemia/reperfusion injury in mice via the cyclic adenosine monophosphate-protein kinase a pathway.Liver TransplIn animals2013
Vasoactive intestinal peptide produces long-lasting changes in neural activity in the suprachiasmatic nucleus.J NeurophysiolIn animals2013
Chemical synthesis and formulation design of a PEGylated vasoactive intestinal peptide derivative with improved metabolic stability.Eur J Pharm SciIn animals2013
VIPhyb, an antagonist of vasoactive intestinal peptide receptor, enhances cellular antiviral immunity in murine cytomegalovirus infected mice.PLoS OneIn animals2013
Corneal Endothelial Cell Integrity in Precut Human Donor Corneas Enhanced by Autocrine Vasoactive Intestinal Peptide.CorneaIn a lab dish2017
Vasoactive intestinal peptide represses activation of tumor-associated macrophages in gastric cancer via regulation of TNFα, IL-6, IL-12 and iNOS.Int J OncolIn a lab dish2015
Vasoactive intestinal peptide induces an immunosuppressant microenvironment in the maternal-fetal interface of non-obese diabetic mice and improves early pregnancy outcome.Am J Reprod ImmunolIn a lab dish2014
Vasoactive intestinal peptide regulates sinonasal mucociliary clearance and synergizes with histamine in stimulating sinonasal fluid secretion.FASEB JIn a lab dish2013
Vasoactive intestinal peptide can promote the development of neonatal rat primordial follicles during in vitro culture.Biol ReprodIn a lab dish2013
Regulation of vasoactive intestinal peptide and substance P in the human pyloric sphincter.HepatogastroenterologyIn a lab dish2009
Inhibitory effect of hypochlorous acid on lower esophageal sphincter tone relaxation by vasoactive intestinal peptide.Arch Pharm ResIn a lab dish2008
Depot formulation of vasoactive intestinal peptide by protamine-based biodegradable nanoparticles.J Control ReleaseIn a lab dish2008
Inhalable liposomal formulation for vasoactive intestinal peptide.Int J PharmIn a lab dish2008
Regulation of the peptidergic nerves (substance P and vasoactive intestinal peptide) in the colon of women patients with slow transit constipation: an in vitro study.HepatogastroenterologyIn a lab dish2008
Vasoactive intestinal peptide prevents activated microglia-induced neurodegeneration under inflammatory conditions: potential therapeutic role in brain trauma.FASEB JIn a lab dish2003
Melatonin attenuates alpha-adrenergic-induced contractions by increasing the release of vasoactive intestinal peptide in isolated rat penile bulb.Urol ResIn a lab dish2003
The regulatory action of estrogen and vasoactive intestinal peptide on prolactin secretion in sea bream (Sparus aurata, L.).Gen Comp EndocrinolIn a lab dish2003
Inhibitory effect of oatmeal extract oligomer on vasoactive intestinal peptide-induced inflammation in surviving human skin.Int J Tissue ReactIn a lab dish2003
Influence of 4-day long treatment with vasoactive intestinal peptide on ultrastructure and function of the rat pinealocytes in organ culture.Folia Histochem CytobiolIn a lab dish2002
Intestinal adaptation in atrophic rat ileum is accompanied by supersensitivity to vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide and nitric oxide.Scand J GastroenterolIn a lab dish2001
Inhibitory effect of Avene spring water on vasoactive intestinal peptide-induced inflammation in surviving human skin.Int J Tissue ReactIn a lab dish2001
The effect of stress and in vivo vasoactive intestinal peptide (VIP) treatment on the response of isolated rat aorta to norepinephrine, angiotensin II and vasopressin, and adventitial mast cells.StressIn a lab dish2000
99mTc-labeled vasoactive intestinal peptide receptor agonist: functional studies.J Nucl MedIn a lab dish1999
Pharmacologically distinct vasoactive intestinal peptide binding sites: CNS localization and role in embryonic growth.NeuroscienceIn a lab dish1999
Vasoactive intestinal peptide enhances its own expression in sympathetic neurons after injury.J NeurosciIn a lab dish1998
Vasoactive intestinal peptide shortens both G1 and S phases of neural cell cycle in whole postimplantation cultured mouse embryos.Eur J NeurosciIn a lab dish1998
Vasoactive intestinal peptide stimulation of human trabecular meshwork cell growth.Invest Ophthalmol Vis SciIn a lab dish1997
Transcription of the vasoactive intestinal peptide gene in response to glucocorticoids: differential regulation of alternative transcripts is modulated by a labile protein in rat anterior pituitary.Mol Cell EndocrinolIn a lab dish1997
Gs and Gq/11 couple vasoactive intestinal peptide and cholinergic stimulation to lacrimal secretion.Invest Ophthalmol Vis SciIn a lab dish1997
Alpha-latrotoxin-induced transmitter release in feline oesophageal smooth muscle: focus on nitric oxide and vasoactive intestinal peptide.Br J PharmacolIn a lab dish1997
Mechanisms of action of cholecystokinin in the canine gastrointestinal tract: role of vasoactive intestinal peptide and nitric oxide.J Pharmacol Exp TherIn a lab dish1996
Vasoactive intestinal peptide associated 8-gene signature with prognostic and immune associations in melanoma.Medicine (Baltimore)Other paper2026
Vasoactive Intestinal Peptide Induces Autophagy and Cytotoxicity in Renal Cell Carcinoma via SIRT3-Dependent Signaling Pathway.J Biochem Mol ToxicolOther paper2026
Clinical implications of vasoactive intestinal peptide and 5-hydroxytryptamine in diabetic neurogenic bladder and their relationship with post-void residual.J Med BiochemOther paper2026
Vasoactive intestinal peptide modified defect-engineered ZnOx-Au-NaBH4 nanoplatform inducing pyroptosis in fibroblast-like synoviocytes for therapy of rheumatoid arthritis.Int J Biol MacromolOther paper2026
Vasoactive intestinal peptide reduces ocular hypertension by regulating tight junction of trabecular meshwork through Rab13/PKA signalling complex.Ann MedOther paper2025
Vasoactive Intestinal Peptide: A Neuropeptide that Plays an Important Role in Parkinson's Disease.Curr NeuropharmacolOther paper2025
Vasoactive Intestinal Peptide (VIP) in COVID-19 Therapy-Shedding of ACE2 and TMPRSS2 via ADAM10.Int J Mol SciOther paper2025
Microglia cells treated with synthetic vasoactive intestinal peptide or transduced with LentiVIP protect neuronal cells against degeneration.Eur J NeurosciOther paper2024
Blockade of vasoactive intestinal peptide receptor 2 (VIPR2) signaling suppresses cyclin D1-dependent cell-cycle progression in MCF-7 cells.J Pharmacol SciOther paper2024
Vasoactive Intestinal Peptide Receptor, CRTH2, Antagonist Treatment Improves Eosinophil and Mast Cell-Mediated Esophageal Remodeling and Motility Dysfunction in Eosinophilic Esophagitis.CellsOther paper2024
Effect of Aviptadil, a Novel Therapy, on Clinical Outcomes of Patients with Viral-related Severe ARDS: A Retrospective Observational Study.Indian J Crit Care MedOther paper2024
Drugs and natural products for the treatment of COVID-19 during 2020, the first year of the pandemic.Bol Med Hosp Infant MexOther paper2024
Peptiligase, an enzyme for efficient chemo-enzymatic synthesis of aviptadil.Int J Biol MacromolOther paper2023
Vasoactive intestinal peptide receptor 2 signaling promotes breast cancer cell proliferation by enhancing the ERK pathway.PeptidesOther paper2023
Targeting vasoactive intestinal peptide-mediated signaling enhances response to immune checkpoint therapy in pancreatic ductal adenocarcinoma.Nat CommunOther paper2022
Inhaled aviptadil for the possible treatment of COVID-19 in patients at high risk for ARDS: study protocol for a randomized, placebo-controlled, and multicenter trial.TrialsOther paper2022
Vasoactive Intestinal Peptide Amphiphile Micelle Chemical Structure and Hydrophobic Domain Influence Immunomodulatory Potentiation.ACS Appl Bio MaterOther paper2022
Protection of Vasoactive Intestinal Peptide on the Blood-Brain Barrier Dysfunction Induced by Focal Cerebral Ischemia in Rats.J Stroke Cerebrovasc DisOther paper2022
Association of BRAF V600E mutations with vasoactive intestinal peptide syndrome in MYCN-amplified neuroblastoma.Pediatr Blood CancerOther paper2021
Overexpressing miR-122-5p Inhibits the Relaxation of Vaginal Smooth Muscle in Female Sexual Arousal Disorder by Targeting Vasoactive Intestinal Peptide Receptor 1.Sex MedOther paper2021
Targeting breast cancer using pirarubicin-loaded vasoactive intestinal peptide grafted sterically stabilized micelles.Eur J Pharm SciOther paper2021
The effects of vasoactive intestinal peptide on RANKL-induced osteoclast formation.Ann Transl MedOther paper2021
Role of free radical scavenging activity of vasoactive intestinal peptide in the attenuation of mitochondrial dysfunction to ameliorate dextran sulphate sodium-induced colitis in mice: Implications in ulcerative colitis.J Dig DisOther paper2020
Protective Effects of Pituitary Adenylate Cyclase-Activating Polypeptide and Vasoactive Intestinal Peptide Against Cognitive Decline in Neurodegenerative Diseases.Front Cell NeurosciOther paper2020
Vasoactive intestinal peptide infusion reverses existing myocardial fibrosis in the rat.Eur J PharmacolOther paper2019
Associations between the severity of reflux esophagitis in children and changes in oxidative stress, serum inflammation, vasoactive intestinal peptide and motilin.Exp Ther MedOther paper2019
Vasoactive intestinal peptide alleviates food allergy via restoring regulatory B cell functions.ImmunobiologyOther paper2019
Vasoactive Intestinal Peptide Immunoregulatory Role at the Periapex: Associative and Mechanistic Evidences from Human and Experimental Periapical Lesions.J EndodOther paper2019
A Synthetic Agonist to Vasoactive Intestinal Peptide Receptor-2 Induces Regulatory T Cell Neuroprotective Activities in Models of Parkinson's Disease.Front Cell NeurosciOther paper2019
A Molecular Dynamics Study of Vasoactive Intestinal Peptide Receptor 1 and the Basis of Its Therapeutic Antagonism.Int J Mol SciOther paper2019
Diagnostic and Management Challenges in Vasoactive Intestinal Peptide Secreting Tumors: A Series of 15 Patients.PancreasOther paper2019
[Reflexions on 50 Years of Sexual Medicine in Urology Focusing on Male Sexual Dysfunctions].Aktuelle UrolOther paper2019
Serum substance P and vasoactive intestinal peptide levels in infants with acute intussusception.J Int Med ResOther paper2019
Vasoactive intestinal peptide is required in the maintenance of immune regulatory competency of immune regulatory monocytes.Clin Exp ImmunolOther paper2019
Vasoactive intestinal peptide stabilizes intestinal immune homeostasis through maintaining interleukin-10 expression in regulatory B cells.TheranosticsOther paper2019
Vasoactive intestinal peptide increases apoptosis of hepatocellular carcinoma by inhibiting the cAMP/Bcl-xL pathway.Cancer SciOther paper2019
Vasoactive intestinal peptide induces proliferation of human hepatocytes.Cell ProlifOther paper2018
Colonic levels of vasoactive intestinal peptide decrease during infection and exogenous VIP protects epithelial mitochondria against the negative effects of IFNγ and TNFα induced during Citrobacter rodentium infection.PLoS OneOther paper2018
Vasoactive Intestinal Peptide Promotes Corneal Allograft Survival.Am J PatholOther paper2018
The Neural Signals of the Superior Ovarian Nerve Modulate in an Asymmetric Way the Ovarian Steroidogenic Response to the Vasoactive Intestinal Peptide.Front PhysiolOther paper2018
HIV-based lentivirus-mediated vasoactive intestinal peptide gene delivery protects against DIO animal model of Type 2 diabetes.Gene TherOther paper2018
Role of vasoactive intestinal peptide in Aspergillus fumigatus-infected cornea.Int J OphthalmolOther paper2018
Recombinant expressed vasoactive intestinal peptide analogue ameliorates TNBS-induced colitis in rats.World J GastroenterolOther paper2018
Vasoactive intestinal peptide gene polymorphisms, associated with its serum levels, predict treatment requirements in early rheumatoid arthritis.Sci RepOther paper2018
Vasoactive Intestinal Peptide Nanomedicine for the Management of Inflammatory Bowel Disease.Mol PharmOther paper2017
Cytoprotective effect of neuropeptides on cancer stem cells: vasoactive intestinal peptide-induced antiapoptotic signaling.Cell Death DisOther paper2017
Modulation of Immune Checkpoints and Graft-versus-Leukemia in Allogeneic Transplants by Antagonizing Vasoactive Intestinal Peptide Signaling.Cancer ResOther paper2016
Vinpocetine and Vasoactive Intestinal Peptide Attenuate Manganese-Induced Toxicity in NE-4C Cells.Biol Trace Elem ResOther paper2016
Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse.Br J DermatolOther paper2016
Curcumin Ameliorates Reserpine-Induced Gastrointestinal Mucosal Lesions Through Inhibiting IκB-α/NF-κB Pathway and Regulating Expression of Vasoactive Intestinal Peptide and Gastrin in Rats.J Med FoodOther paper2016
Effect of vasoactive intestinal peptide on the wound healing of alkali-burned corneas.Int J OphthalmolOther paper2016

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Registered studies in people (20)

StudiesStageStatusPeople taking partUpdated
Inhaled ZYESAMI (Aviptadil Acetate) for Treatment of Severe COVID-19Stage 3Withdrawn02026-05-14
I-SPY COVID-19 TRIAL: An Adaptive Platform Trial for Critically Ill PatientsStage 2Running, no new people15002026-03-16
ACTIV-3b: Therapeutics for Severely Ill Inpatients With COVID-19Stage 3Finished4732025-10-24
Aviptadil for Severely Ill Inpatients With COVID-19 (An ACTIV-3b/TESICO Treatment Trial)Stage 3Finished4712025-10-09
Inhaled Aviptadil for the Treatment of COVID-19 in Patients at High Risk for ARDSStage 2Stopped early832024-01-18
Intravenous Aviptadil for Critical COVID-19 With Respiratory FailureStage 2, Stage 3Finished2032023-07-24
A Clinical Study Evaluating Inhaled Aviptadil on COVID-19Stage 2Finished802023-06-05
Inhaled ZYESAMI™ (Aviptadil Acetate) for the Treatment of Severe COVID-19Stage 2, Stage 3Stopped early1442023-02-03
ZYESAMI (Aviptadil) Intermediate Population Expanded Access Protocol (SAMICARE)–Access ended–2023-02-03
Phase 2 Study to Assess Safety, Tolerability and Efficacy of Once Weekly SC Pemziviptadil (PB1046) in Subjects With Symptomatic PAHStage 2Stopped early352022-08-23
Phase I Study of Vasoactive Intestinal Peptide in Patients With Acute Respiratory Distress Syndrome and SepsisStage 1Finished182022-05-04
Pemziviptadil (PB1046), a Long-acting, Sustained Release Human VIP Analogue, Intended to Provide Clinical Improvement to Hospitalized COVID-19 Patients at High Risk for Rapid Clinical Deterioration and Acute Respiratory Distress Syndrome (ARDS).Stage 2Stopped early542020-12-11
The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) in Episodic Migraine Patients–Finished212020-10-20
The Effects of a Long-lasting Infusion of Vasoactive Intestinal Peptide (VIP) on Headache, Cranial Hemodynamic and Autonomic Symptoms in Healthy Volunteers–Finished122020-08-20
A Study to Assess the Safety, Tolerability, and Hemodynamic Response of PB1046 in Subjects With PAHStage 1Finished32019-10-08
Plastic Bronchitis and Protein Losing Enteropathy in Children With Single Ventricle Physiology–Finished202013-10-29
Effect of PACAP38/VIP on Migraineurs Measured by Magnetic Resonance–Finished242012-08-29
Vasoactive Intestinal Peptide in COPD–Finished342007-04-24
Hemodynamic and Headache-Inducing Effect of Intravenous Vasoactive Intestinal Peptide in Migraineurs–Finished122006-01-09
Experimental Headache Induced by Vasoactive Intestinal Polypeptide–Finished122005-12-09