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The US health department published a draft policy under which it would not act against pharmacies that make BPC-157 on a prescription for a named patient, until the FDA decides by rule. It is still not an approved medicine.
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Tesamorelin

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Scientific papers

StudiesKind of studyYear
Efficacy and Safety of Tesamorelin in People Living With HIV (PLWH) With Lipodystrophy: A Systematic Review and Meta-Analysis.J Int Assoc Provid AIDS CarePooled analysis2026
Body composition, hepatic fat, metabolic, and safety outcomes of Tesamorelin, a GHRH analogue, in HIV-associated lipodystrophy: A meta-analysis of randomized controlled trials.Obes Res Clin PractPooled analysis2026
Effects of Tesamorelin on Neurocognitive Impairment in Persons With HIV and Abdominal Obesity.J Infect DisRandom groups2025
Efficacy and safety of tesamorelin in people with HIV on integrase inhibitors.AIDSRandom groups2024
Growth Hormone Releasing Hormone Reduces Circulating Markers of Immune Activation in Parallel with Effects on Hepatic Immune Pathways in Individuals with HIV-infection and Nonalcoholic Fatty Liver Disease.Clin Infect DisRandom groups2021
Clinical Predictors of Liver Fibrosis Presence and Progression in Human Immunodeficiency Virus-Associated Nonalcoholic Fatty Liver Disease.Clin Infect DisRandom groups2021
Effects of tesamorelin on hepatic transcriptomic signatures in HIV-associated NAFLD.JCI InsightRandom groups2020
Effects of tesamorelin on non-alcoholic fatty liver disease in HIV: a randomised, double-blind, multicentre trial.Lancet HIVRandom groups2019
The Growth Hormone Releasing Hormone Analogue, Tesamorelin, Decreases Muscle Fat and Increases Muscle Area in Adults with HIV.J Frailty AgingRandom groups2019
Fibroblast growth factor 21 decreases after liver fat reduction via growth hormone augmentation.Growth Horm IGF ResRandom groups2017
Safety and metabolic effects of tesamorelin, a growth hormone-releasing factor analogue, in patients with type 2 diabetes: A randomized, placebo-controlled trial.PLoS OneRandom groups2017
Predictors of Treatment Response to Tesamorelin, a Growth Hormone-Releasing Factor Analog, in HIV-Infected Patients with Excess Abdominal Fat.PLoS OneRandom groups2015
Population pharmacokinetic analysis of tesamorelin in HIV-infected patients and healthy subjects.Clin PharmacokinetRandom groups2015
The effects of tesamorelin on phosphocreatine recovery in obese subjects with reduced GH.J Clin Endocrinol MetabRandom groups2014
Growth hormone-releasing hormone effects on brain γ-aminobutyric acid levels in mild cognitive impairment and healthy aging.JAMA NeurolRandom groups2013
Metabolic effects of a growth hormone-releasing factor in obese subjects with reduced growth hormone secretion: a randomized controlled trial.J Clin Endocrinol MetabRandom groups2012
Effects of growth hormone–releasing hormone on cognitive function in adults with mild cognitive impairment and healthy older adults: results of a controlled trial.Arch NeurolRandom groups2012
Reduction in visceral adiposity is associated with an improved metabolic profile in HIV-infected patients receiving tesamorelin.Clin Infect DisRandom groups2012
Effects of tesamorelin on inflammatory markers in HIV patients with excess abdominal fat: relationship with visceral adipose reduction.AIDSRandom groups2011
Long-term safety and effects of tesamorelin, a growth hormone-releasing factor analogue, in HIV patients with abdominal fat accumulation.AIDSRandom groups2008
Metabolic effects of a growth hormone-releasing factor in patients with HIV.N Engl J MedRandom groups2007
Population pharmacokinetic and pharmacodynamic analysis of tesamorelin in HIV-infected patients and healthy subjects.J Pharmacokinet PharmacodynNo random groups2015
Relationship of adiponectin to endogenous GH pulse secretion parameters in response to stimulation with a growth hormone releasing factor.Growth Horm IGF ResNo random groups2011
Differing Presentations of Excess Visceral Abdominal Fat in People Living With HIV: Two Clinical Cases Highlighting Distinct Therapeutic Pathways With Tesamorelin and Glucagon-Like Peptide-1 Receptor Agonists.Clin Infect DisCase reports2026
Approach to the Patient With Lipodystrophy.J Clin Endocrinol MetabCase reports2022
Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review.Sex Med RevReview of studies2026
The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.Front Endocrinol (Lausanne)Review of studies2026
Injectable Peptides in Sports Medicine: A Structured Narrative Review of Evidence, Safety, and Antidoping Implications.JBJS RevReview of studies2026
Therapeutic Peptides in Aesthetic, Metabolic and Endocrine Conditions: Effects, Safety, Clinical Applications, and Future Perspectives.Int J Mol SciReview of studies2026
Pharmacologic Treatments for the Preservation of Lean Body Mass During Weight Loss.J Clin MedReview of studies2026
Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.J Am Acad Orthop Surg Glob Res RevReview of studies2026
Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.Am J Sports MedReview of studies2026
Metabolic dysfunction-associated steatotic liver disease in people with HIV.Curr Opin HIV AIDSReview of studies2025
CROI 2024: Neuropsychiatric Complications in People With HIV.Top Antivir MedReview of studies2024
Causes and outcomes of hepatic fibrosis in persons living with HIV.Curr Opin HIV AIDSReview of studies2022
Non-Alcoholic Steatohepatitis (NASH) - A Review of a Crowded Clinical Landscape, Driven by a Complex Disease.Drug Des Devel TherReview of studies2021
Cardiovascular risk and dyslipidemia among persons living with HIV: a review.BMC Infect DisReview of studies2017
Growth hormone deficiency and human immunodeficiency virus.Best Pract Res Clin Endocrinol MetabReview of studies2017
Therapeutic augmentation of the growth hormone axis to improve outcomes following peripheral nerve injury.Expert Opin Ther TargetsReview of studies2016
Growth hormone in the aging male.Best Pract Res Clin Endocrinol MetabReview of studies2013
Pathophysiology of GHRH-growth hormone-IGF1 axis in HIV/AIDS.Rev Endocr Metab DisordReview of studies2013
How to diagnose a lipodystrophy syndrome.Ann Endocrinol (Paris)Review of studies2012
Tesamorelin: a growth hormone-releasing factor analogue for HIV-associated lipodystrophy.Ann PharmacotherReview of studies2012
Spotlight on tesamorelin in HIV-associated lipodystrophy.BioDrugsReview of studies2011
Growth hormone axis treatments for HIV-associated lipodystrophy: a systematic review of placebo-controlled trials.HIV MedReview of studies2011
Tesamorelin: a review of its use in the management of HIV-associated lipodystrophy.DrugsReview of studies2011
Pathogenesis and treatment of HIV lipohypertrophy.Curr Opin Infect DisReview of studies2011
Growth hormone-releasing factor agonists for the treatment of HIV-associated lipodystrophy.Curr Opin Investig DrugsReview of studies2010
Epidemiology, assessment, and management of excess abdominal fat in persons with HIV infection.AIDS RevReview of studies2010
Tesamorelin, a human growth hormone releasing factor analogue.Expert Opin Investig DrugsReview of studies2009
Drug evaluation: tesamorelin, a synthetic human growth hormone releasing factor.Curr Opin Investig DrugsReview of studies2006
Combined antiretroviral therapy with low- or normal-protein, high-calorie diets appears to induce significant deleterious electrocardiographic changes in a rodent model.Braz J Med Biol ResIn animals2026
Advances in the detection of growth hormone releasing hormone synthetic analogs.Drug Test AnalIn a lab dish2021
The effect of growth hormone-releasing hormone on cognition and brain connectivity in adults with cognition ranging from normal to mild cognitive impairment.eNeurologicalSciOther paper2026
Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIV (TRIUMPH): a clinical trial protocol.BMJ OpenOther paper2026
Analysis of growth hormone releasing hormone and its analogs in urine using nano liquid chromatography coupled with quadrupole/orbitrap mass spectrometry.J Pharm Biomed AnalOther paper2026
Carpal Tunnel Syndrome Attributed to Medication Use: A Pharmacovigilance Study.CureusOther paper2025
Dietary regimens appear to possess significant effects on the development of combined antiretroviral therapy (cART)-associated metabolic syndrome.PLoS OneOther paper2024
Chromatographic-mass spectrometric analysis of peptidic analytes (2-10 kDa) in doping control urine samples.J Mass SpectromOther paper2024
Cationic exchange SPE combined with triple quadrupole UHPLC-MS/MS for detection of GHRHs in urine samples.Anal BiochemOther paper2023
Effect of tesamorelin in people with HIV with and without dorsocervical fat: Post hoc analysis of phase III double-blind placebo-controlled trial.J Clin Transl SciOther paper2023
Probing for peptidic drugs (2-10 kDa) in doping control blood samples.Anal Sci AdvOther paper2022
An antibody-free, ultrafiltration-based assay for the detection of growth hormone-releasing hormones in urine at low pg/mL concentrations using nanoLC-HRMS/MS.J Pharm Biomed AnalOther paper2022
Tesamorelin improves fat quality independent of changes in fat quantity.AIDSOther paper2021
Delineating tesamorelin response pathways in HIV-associated NAFLD using a targeted proteomic and transcriptomic approach.Sci RepOther paper2021
Comparison of magnetic bead surface functionalities for the immunopurification of growth hormone-releasing hormones prior to liquid chromatography-high resolution mass spectrometry.J Chromatogr AOther paper2020
Peptide Ligation at High Dilution via Reductive Diselenide-Selenoester Ligation.J Am Chem SocOther paper2020
Comparison of visceral fat measurement by dual-energy X-ray absorptiometry to computed tomography in HIV and non-HIV.Nutr DiabetesOther paper2019
Visceral fat reduction with tesamorelin is associated with improved liver enzymes in HIV.AIDSOther paper2017
Qualitative identification of growth hormone-releasing hormones in human plasma by means of immunoaffinity purification and LC-HRMS/MS.Anal Bioanal ChemOther paper2016
Expanded test method for peptides >2 kDa employing immunoaffinity purification and LC-HRMS/MS.Drug Test AnalOther paper2015
Impact of Tesamorelin, a Growth Hormone-Releasing Factor (GRF) Analogue, on the Pharmacokinetics of Simvastatin and Ritonavir in Healthy Volunteers.Clin Pharmacol Drug DevOther paper2013
Neuroendocrinology: Tesamorelin can improve cognitive function.Nat Rev EndocrinolOther paper2012
Pathogenesis and treatment of human immunodeficiency virus lipodystrophy.Indian J Endocrinol MetabOther paper2012
Tesamorelin: a novel therapeutic option for HIV/HAART-associated increased visceral adipose tissue.Drugs Today (Barc)Other paper2011
Tesamorelin: A hope for ART-induced lipodystrophy.J Pharm Bioallied SciOther paper2011
Tesamorelin for the treatment of excess abdominal fat in HIV-1-infected patients with lipodystrophy.Expert Rev Endocrinol MetabOther paper2011
Growth hormone and tesamorelin in the management of HIV-associated lipodystrophy.HIV AIDS (Auckl)Other paper2011
Effects of a growth hormone-releasing hormone analog on endogenous GH pulsatility and insulin sensitivity in healthy men.J Clin Endocrinol MetabOther paper2011
Effects of tesamorelin (TH9507), a growth hormone-releasing factor analog, in human immunodeficiency virus-infected patients with excess abdominal fat: a pooled analysis of two multicenter, double-blind placebo-controlled phase 3 trials with safety extension data.J Clin Endocrinol MetabOther paper2010
Tesamorelin update.BETAOther paper2010
The next generation of human growth hormone. How Serostim and tesamorelin measure up.Posit AwareOther paper2008
Tesamorelin for fat accumulation. 52-week effects and safety of tesamorelin (growth hormone releasing factor) in HIV patients with fat accumulation.Posit AwareOther paper2008
Side effects and complications. Tesamorelin--results from Phase III.TreatmentUpdateOther paper2007
Side effects and complications. Clinical trials of tesamorelin in Canada.TreatmentUpdateOther paper2007

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Registered studies in people (22)

StudiesStageStatusPeople taking partUpdated
Body Composition and Adipose Tissue in HIVStage 4Stopped early62026-05-19
Tesamorelin as an Adjunct to Exercise for Improving Physical Function in HIVStage 2Looking for people1002026-05-19
Tesamorelin for Reduction of Liver Fat in Adults With Fatty Liver Disease (Mock Study)Stage 2Looking for people1202026-03-19
Phase II Trial of Tesamorelin for Cognition in Aging HIV-Infected PersonsStage 2Finished732026-03-12
Growth Hormone Releasing Hormone Analog to Improve Nonalcoholic Fatty Liver Disease and Associated Cardiovascular RiskStage 2Finished512025-11-20
Tesamorelin to Improve Functional Outcomes After Peripheral Nerve InjuryStage 2Looking for people362025-11-12
TH9507 Extension Study in Patients With HIV-Associated LipodystrophyStage 3Finished2632022-09-30
Efficacy and Safety Study of Tesamorelin in Chronic Obstructive Pulmonary Disease (COPD) Subjects With Muscle WastingStage 2Stopped early32022-03-18
Tesamorelin Effects on Liver Fat and Histology in HIV–Finished612020-01-27
Impact of GHRH on Sleep Promotion and Endocrine Regulation in Service Members Who Sustained a Traumatic Brain Injury and Have Current InsomniaStage 2Withdrawn02019-11-19
The Effect of Growth Hormone Releasing Hormone on Cognitive Function in Individuals With Mild Cognitive ImpairmentStage 1Finished222019-11-04
Long-term Observational Study in HIV Subjects Exposed to EGRIFTA®–Stopped early3912018-09-11
Diabetic Retinopathy in HIV Subjects Treated With EGRIFTA®Stage 4Stopped early1292018-09-11
Effectiveness of Growth Hormone Releasing Hormone in Reducing Abdominal Fat in People Who Are ObeseStage 2Finished602017-12-13
Effects of Growth Hormone Releasing Hormone in HIV–Finished542017-10-30
Egrifta Replacement and Sleep Disordered Breathing–Withdrawn02017-03-03
Abdominal Obesity, Cardiovascular Inflammation, and Effects of Growth Hormone Releasing Hormone Analogue–Withdrawn02014-01-24
SMART: Somatotrophics, Memory, and Aging Research TrialStage 2Finished1512013-12-19
Pharmacokinetic and Pharmacodynamic Study of TH9507, a Growth Hormone-Releasing Factor Analog, in HIV Positive PatientsStage 1Finished182013-12-16
TH9507 in Patients With HIV-Associated LipodystrophyStage 3Finished4122013-11-27
Effect of Short Term Growth Hormone Releasing Hormone in Healthy Men–Finished152011-04-19
Safety Study of TH9507 in Subjects With Stable, Type 2 DiabetesStage 2Finished552010-12-21