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The US health department published a draft policy under which it would not act against pharmacies that make BPC-157 on a prescription for a named patient, until the FDA decides by rule. It is still not an approved medicine.
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Retatrutide

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Scientific papers

StudiesKind of studyYear
Effect of Retatrutide, a Novel Triple Receptor Agonist, on Blood Pressure and Lipid Levels: A Systematic Review and Meta-analysis of Randomized Controlled Trials.High Blood Press Cardiovasc PrevPooled analysis2026
Benefits and Harms of Pharmacologic Treatments in Adults With Overweight or Obesity: A Living Systematic Review and Network Meta-analysis for the American College of Physicians.Ann Intern MedPooled analysis2026
Comparative effects of drugs for adults with overweight or obesity: systematic review and network meta-analysis.BMJPooled analysis2026
Effect of incretin-based therapies on blood pressure: a systematic review and meta-analysis.Eur J Prev CardiolPooled analysis2026
Comparative Efficacy and Safety of Glucagon Receptor Agonists on Metabolic Outcomes: A Network Meta-Analysis of Randomised Controlled Trials.Endocrinol Diabetes MetabPooled analysis2026
Efficacy and Safety of GLP-1 Receptor Agonists, Dual Agonists, and Retatrutide for Weight Loss in Adults With Overweight or Obesity: A Bayesian NMA.Obesity (Silver Spring)Pooled analysis2025
Efficacy of GLP-1-based Therapies on Metabolic Dysfunction-associated Steatotic Liver Disease and Metabolic Dysfunction-associated Steatohepatitis: A Systematic Review and Meta-analysis.J Clin Endocrinol MetabPooled analysis2025
Evaluating the Rates of Pancreatitis and Pancreatic Cancer Among GLP-1 Receptor Agonists: A Systematic Review and Meta-Analysis of Randomised Controlled Trials.Endocrinol Diabetes MetabPooled analysis2025
Beyond GLP-1: efficacy and safety of dual and triple incretin agonists in personalized type 2 diabetes care-a systematic review and network meta-analysis.Acta DiabetolPooled analysis2025
Quantitative Comparison of Glucagon-Like Peptide-1 Receptor Agonists on Weight Loss in Adults: A Systematic Review and Model-Based Meta-Analysis.Diabetes Technol TherPooled analysis2025
Efficacy of GLP-1 Receptor Agonist-Based Therapies on Cardiovascular Events and Cardiometabolic Parameters in Obese Individuals Without Diabetes: A Meta-Analysis of Randomized Controlled Trials.J DiabetesPooled analysis2025
Sex Differences in the Efficacy of Glucagon-Like Peptide-1 Receptor Agonists for Weight Reduction: A Systematic Review and Meta-Analysis.J DiabetesPooled analysis2025
Comparative efficacy of incretin drugs on glycemic control, body weight, and blood pressure in adults with overweight or obesity and with/without type 2 diabetes: a systematic review and network meta-analysis.Front Endocrinol (Lausanne)Pooled analysis2025
Efficacy and safety of triple hormone receptor agonist retatrutide for the management of obesity: a systematic review and meta-analysis.Expert Rev Clin PharmacolPooled analysis2025
Seven glucagon-like peptide-1 receptor agonists and polyagonists for weight loss in patients with obesity or overweight: an updated systematic review and network meta-analysis of randomized controlled trials.MetabolismPooled analysis2024
Retatrutide-Associated Improvements in Cardiovascular Risk Biomarkers in Adults With Obesity With or Without Type 2 Diabetes.Diabetes Obes MetabRandom groups2026
Retatrutide and lipid and metabolite profiles in participants with obesity with or without type 2 diabetes.J Clin Endocrinol MetabRandom groups2026
Efficacy and safety of retatrutide, a GIP, GLP-1, and glucagon receptor agonist, in people with type 2 diabetes and inadequate glycaemic control with diet and exercise (TRANSCEND-T2D-1): a double-blind, randomised, phase 3 trial.LancetRandom groups2026
Appetite, eating attitudes, and eating behaviours during treatment with retatrutide in adults with type 2 diabetes: Results of a phase 2 study.Diabetes Obes MetabRandom groups2025
Triple hormone receptor agonist retatrutide for metabolic dysfunction-associated steatotic liver disease: a randomized phase 2a trial.Nat MedRandom groups2024
Retatrutide, a GIP, GLP-1 and glucagon receptor agonist, for people with type 2 diabetes: a randomised, double-blind, placebo and active-controlled, parallel-group, phase 2 trial conducted in the USA.LancetRandom groups2023
LY3437943, a novel triple GIP, GLP-1, and glucagon receptor agonist in people with type 2 diabetes: a phase 1b, multicentre, double-blind, placebo-controlled, randomised, multiple-ascending dose trial.LancetRandom groups2022
Decreases in circulating ANGPTL3/8 concentrations following retatrutide treatment parallel reductions in serum lipids.Diabetes Obes MetabNo random groups2025
Sustained weight loss exceeding 100 kg with sequential incretin-based therapy in Prader-Willi syndrome.JCEM Case RepCase reports2026
Online-Sourced Retatrutide Complicating Impending Diabetic Ketoacidosis in a Patient With Type 1 Diabetes and Concurrent Shigella Gastroenteritis.CureusCase reports2026
GLP-1 receptor biology and the therapeutic role of incretin-based agonists in metabolic diseases.Eur J PharmacolReview of studies2026
The pharmacotherapy for pediatric obesity: insights and challenges from adult weight-loss medications.J Diabetes Metab DisordReview of studies2026
The First Triple Agonist for Antiobesity: Retatrutide.Cardiol RevReview of studies2026
Glucose-dependent insulinotropic polypeptide (GIP) signaling in visceral and subcutaneous adipose tissue: implications for obesity and metabolic disease-a narrative review with a structured literature search.Rev Endocr Metab DisordReview of studies2026
Medical treatments for obesity: what does the future have in store?J Clin Endocrinol MetabReview of studies2026
Do Glucagon-Like Peptide-1 Receptor Agonists Sabotage Fat Grafts?: A Scoping Review of Glucagon-Like Peptide-1 Receptor Agonist Effects on Adipocyte Biology and Implications for Autologous Fat Transfer.Aesthet Surg JReview of studies2026
GLP-1 receptor agonists and hair loss: adverse effect, epiphenomenon, or therapeutic paradox?Acta DiabetolReview of studies2026
From pathophysiology to therapy: dual and triple agonists as a new frontier in metabolic dysfunction-associated steatotic liver disease.Front PharmacolReview of studies2026
Progress in Anti-Obesity Drug Development: A Pharmacodynamics Perspective.PharmaceuticsReview of studies2026
Retatrutide as a Unimolecular GIP/GLP-1/Glucagon Receptor Tri-Agonist: Molecular Design, Pharmaceutical Development and Critical Interpretation of Emerging Phase 3 Evidence.PharmaceuticsReview of studies2026
Single or multiple nutritional hormone receptor modulators for chronic kidney disease.Clin Kidney JReview of studies2026
Gastrointestinal adverse effects of GLP-1 receptor agonists and dual GIP/GLP-1 receptor agonists: A narrative expert review of approved therapies, oral formulations, and pipeline agents.Nutr Clin PractReview of studies2026
Efficacy and Safety of Glucagon-like Peptide-1 Receptor Agonists and Co-agonists for Weight Loss Among Adults Without Diabetes : An Updated Systematic Review.Ann Intern MedReview of studies2026
GLP-1, GIP, and Glucagon Receptor Agonism at the Obesity-Neurodegeneration Interface: A Narrative Review.Int J Mol SciReview of studies2026
The Possible Hematological Cost of Metabolic Success: Do Incretin-Based Therapies Silently Trigger Anemia?Med Sci (Basel)Review of studies2026
Modern Obesity Treatment: Efficacy, Safety, and Future Directions of GLP-1 (Glucagon-Like Peptide-1) and GIP (Glucose-Dependent Insulinotropic Polypeptide) Receptor Agonists.CureusReview of studies2026
Obstructive sleep apnea, GLP-1 receptor agonist pharmacotherapy, and the oral microbiome: competing biological influences and implications for oral health monitoring.Clin Oral InvestigReview of studies2026
Advances in the management of obesity: non-pharmacological strategies, herbal formulations, current pharmacotherapy, emerging drugs, and future perspectives.Front Endocrinol (Lausanne)Review of studies2026
Recent Studies on the Effectiveness and Safety of Anti-Obesity Medications: A Scoping Review.Diabetes Metab Syndr ObesReview of studies2026
Beyond Fat Loss: Addressing the Sarcopenia Challenge of Incretin-Based Therapies.Diabetes Metab JReview of studies2026
Pharmacological management of obesity: Current landscape and emerging therapies.Indian J PharmacolReview of studies2026
The role of GLP-1 and GIP receptor agonists in the treatment of diabetes and obesity.Pharmacol ResReview of studies2026
Potential Role of the Triple Receptor Agonist Retatrutide in Antipsychotic-Associated Metabolic Dysfunction Among Clozapine- and Olanzapine-Treated Schizophrenia Spectrum Disorders: A Narrative Review and Theoretical Framework.BiomedicinesReview of studies2026
GLP-1 and dual GIP/GLP-1 receptor agonists' psychopharmacology and putative neuropsychiatric associated effects: a Bradford Hill-informed, systematic, evaluation.Curr Psychiatry RepReview of studies2026
Anti-Obesity Medications in Longevity and Aesthetic Medicine.J Clin MedReview of studies2026
From insulin resistance to incretin receptor agonism in the prevention of type 2 diabetes mellitus in obese individuals.Curr Med Res OpinReview of studies2026
Beyond weight loss: multisystem benefits of obesity medications.Lancet Diabetes EndocrinolReview of studies2026
Glucagon-like peptide-1 and peptide YY multi-agonism with GEP44 to optimize weight loss and glycemic control while reducing gastrointestinal side effects: the future of anti-obesity pharmacotherapy?Front Endocrinol (Lausanne)Review of studies2026
Incretin analogues as cardiovascular agents: a state-of-the-art review.Front Endocrinol (Lausanne)Review of studies2026
Efficacy and Safety of Dual and Triple Glucagon-Like Peptide-1-Based Polyagonists in Metabolic Dysfunction-Associated Steatotic Liver Disease and Steatohepatitis: A Systematic Review and Meta-Analysis.CureusReview of studies2026
Efficacy and safety of incretin-based therapies in patients with type 2 diabetes mellitus: a network meta-analysis based on clinical trials.Front PharmacolReview of studies2026
GLP-1 Agonists in Adolescent Obesity: A Narrative Review of Single, Dual, and Triple Agonists.Diabetes Metab Syndr ObesReview of studies2026
Synergistic Intervention for Obesity: Integrating Central Appetite Regulation and Peripheral Energy Expenditure.Curr Obes RepReview of studies2026
Obesity pharmacotherapy reimagined: The era of multi-receptor agonists and next-generation metabolic modulators, perspectives and controversies.Metabol OpenReview of studies2026
Childhood obesity and cardiac risk in youth: Emerging challenges toward 2050.Clin Nutr ESPENReview of studies2026
Dysesthesia associated with GLP-1 agonist therapies: data-mining analysis and literature review.Eur J Clin PharmacolReview of studies2026
Diabetes Mellitus and Stroke: Pathophysiological Connections and Therapeutic Potential of GLP-1 and GLP-1/GIP Receptor Agonists.PharmaceuticsReview of studies2026
Metabolic Dysfunction-Associated Steatotic Liver Disease and Incretin Receptor Agonists: A Metabolic Approach to Halting Liver Disease Progression.Medicina (Kaunas)Review of studies2026
Metabolic inflammation at the adipose-brain axis.Front PhysiolReview of studies2026
Evolution of incretin-based therapies: From GLP-1 monotherapy to dual and triple agonists: A new era in metabolic therapy.Indian J Med ResReview of studies2026
Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions.Liver IntReview of studies2026
Retatrutide in type 2 diabetes mellitus and obesity: an overview.Expert Rev Clin PharmacolReview of studies2026
Engineered nutrient-stimulated hormonal multi-agonists for precision targeting of obesity and metabolic disorders.Clin Mol HepatolReview of studies2026
New Drugs on the Block: Dietary Management and Nutritional Considerations During the Use of Anti-Obesity Medication.NutrientsReview of studies2026
Pharmacologic Treatment of Metabolic Dysfunction-Associated Steatotic Liver Disease in the Context of Type 2 Diabetes.Curr Diab RepReview of studies2026
Novel GLP-1-based Medications for Type 2 Diabetes and Obesity.Endocr RevReview of studies2026
Multi-target incretin-based therapeutics: The rise of dual and triple agonists for metabolic disorders.Eur J Med ChemReview of studies2026
The role of GIP in carbohydrate metabolism: Implications in the development of therapies for T2DM, a narrative review.Histol HistopatholReview of studies2026
Effect of glucagon-like peptide-1 receptor agonists on heart rate in non-diabetic individuals with overweight or obesity: a systematic review and pairwise and network meta-analysis of randomized controlled trials.Eur J Med ResReview of studies2026
Cardiovascular effects of incretin receptor agonists: beyond glycemic control.Can J Physiol PharmacolReview of studies2026
[An historical overview of GLP-1/GIP incretins. From hormone to "swiss-army knife" medications].Biol AujourdhuiReview of studies2026
The Triple-Agonist Revolution: Retatrutide and the Paradigm Shift in Multi-Hormonal Pharmacotherapy for Obesity and Cardiometabolic Comorbidities.Clin Pharmacol Drug DevReview of studies2026
IUPHAR review: From foe to friend: Repurposing glucagon to treat obesity and type 2 diabetes.Pharmacol ResReview of studies2026
Efficacy and Safety of Retatrutide in the Treatment of Diabetes and/or Obesity Comorbid with Chronic Kidney disease: a Systematic Review and Meta-Analysis.Maedica (Bucur)Review of studies2025
Shared mechanistic pathways of glucagon signalling: Unlocking its potential for treating obesity, metabolic dysfunction-associated steatotic liver disease, and other cardio-kidney-metabolic conditions.Diabetes Obes MetabReview of studies2025
Harnessing GLP-1 Receptor Agonists for Obesity Treatment: Prospects and Obstacles on the Horizon.J ObesReview of studies2025
Diabetes Mellitus and Chronic Kidney Disease: The Future Is Being Surpassed.J Clin MedReview of studies2025
Medical Management of Obesity: A Comprehensive Review of Food and Drug Administration (FDA)-Approved and Investigational Therapies.CureusReview of studies2025
Gastrointestinal Adverse Effects of Anti-Obesity Medications in Non-Diabetic Adults: A Systematic Review.Medicina (Kaunas)Review of studies2025
Weight management treatment in obesity.Med Clin (Barc)Review of studies2025
Efficacy of Tirzepatide, Retatrutide, and Semaglutide for Weight Loss in Obese Individuals Without Diabetes.Acad Emerg MedReview of studies2025
Efficacy and safety of anti-obesity drugs in metabolic dysfunction-associated steatotic liver disease: An updated review.World J GastroenterolReview of studies2025
The Effects of Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists on Polycystic Ovarian Syndrome: A Scoping Review.CureusReview of studies2025
Saving muscle while losing weight: A vital strategy for sustainable results while on glucagon-like peptide-1 related drugs.World J DiabetesReview of studies2025
Glucagon-like peptide-1 receptor analogues and beyond: emerging obesity pharmacotherapies.Panminerva MedReview of studies2025
Efficacy and safety of incretin co-agonists: Transformative advances in cardiometabolic healthcare.World J CardiolReview of studies2025
Obesity: Clinical Impact, Pathophysiology, Complications, and Modern Innovations in Therapeutic Strategies.Medicines (Basel)Review of studies2025
Review: Special Issue: Real-world evidence on the use of GLP1 receptor agonists: Emerging concepts in obesity management: focus on glucagon receptor agonist combinations.Drugs ContextReview of studies2025
Efficacy and safety of retatrutide for the treatment of obesity: a systematic review of clinical trials.J Basic Clin Physiol PharmacolReview of studies2025
Antiobesity medications in adult and pediatric obesity and metabolic dysfunction-associated steatotic liver disease.Pharmacol RevReview of studies2025
Retatrutide-A Game Changer in Obesity Pharmacotherapy.BiomoleculesReview of studies2025
Multifunctional incretin peptides in therapies for type 2 diabetes, obesity and associated co-morbidities.PeptidesReview of studies2025
[Glucagon-like peptide-1 receptor agonists: a new pharmacological treatment option for psychiatric illnesses?].NervenarztReview of studies2025
Breaking the weight loss paradox: from weight reduction to cardiovascular benefit in obesity treatment.Pol Arch Intern MedReview of studies2025
Comparative Effectiveness of Semaglutide, Liraglutide, Orlistat, and Phentermine for Weight Loss in Obese Individuals: A Systematic Review.CureusReview of studies2025
The promise of glucagon-like peptide 1 receptor agonists (GLP-1RA) for the treatment of obesity: a look at phase 2 and 3 pipelines.Expert Opin Investig DrugsReview of studies2025
What is the pipeline for future medications for obesity?Int J Obes (Lond)Review of studies2025
Efficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment: a systematic review and meta-analysis of randomized controlled trials.Proc (Bayl Univ Med Cent)Review of studies2025
Efficacy and Safety of Glucagon-Like Peptide-1 Receptor Agonists for Weight Loss Among Adults Without Diabetes : A Systematic Review of Randomized Controlled Trials.Ann Intern MedReview of studies2025
Triple Agonism Based Therapies for Obesity.Curr Cardiovasc Risk RepReview of studies2025
Emerging pharmacotherapies for obesity: A systematic review.Pharmacol RevReview of studies2025
Weight Loss Blockbuster Development: A Role for Unimolecular Polypharmacology.Annu Rev Pharmacol ToxicolReview of studies2025
The power of three: Retatrutide's role in modern obesity and diabetes therapy.Eur J PharmacolReview of studies2024
Why are we still in need for novel anti-obesity medications?Lancet Reg Health EurReview of studies2024
The impact of weight loss on fat-free mass, muscle, bone and hematopoiesis health: Implications for emerging pharmacotherapies aiming at fat reduction and lean mass preservation.MetabolismReview of studies2024
Retatrutide treatment in streptozotocin-induced diabetic rats: renal inflammatory cytokines, HIF‑1α expression, and histopathological injury profile.J Mol HistolIn animals2026
Effects of retatrutide on learning and memory in streptozotocin-induced male diabetic rats.Behav Brain ResIn animals2026
Cagrilintide and retatrutide combination therapy enhances weight loss and metabolic outcomes in obese male rats.Nat MetabIn animals2026
GIPR:GCGR co-agonism restores normal weight in obese rodents.Mol MetabIn animals2026
Retatrutide Shows Multiple Metabolic Benefits in Diet-Induced Obese MASH Mouse and Hamster Models.Obesity (Silver Spring)In animals2026
Semaglutide, tirzepatide, and retatrutide attenuate the interoceptive effects of alcohol in male and female rats.Psychopharmacology (Berl)In animals2026
Efficacy of GLP-1 analog peptides, semaglutide, tirzepatide, and retatrutide on MC4R deficient obesity and their comparison.Int J Obes (Lond)In animals2026
Retatrutide improves steatohepatitis in an accelerated mouse model of diet-induced steatohepatitis with a fructose binge.Am J Physiol Gastrointest Liver PhysiolIn animals2025
Contractile effects of retatrutide in isolated mouse atrial preparations.Naunyn Schmiedebergs Arch PharmacolIn animals2025
Comparison of the effects of Liraglutide, Tirzepatide, and Retatrutide on diabetic kidney disease in db/db mice.EndocrineIn animals2025
LY3437943, a novel triple glucagon, GIP, and GLP-1 receptor agonist for glycemic control and weight loss: From discovery to clinical proof of concept.Cell MetabIn animals2022
Detection and Excretion Profile of Retatrutide in Human Plasma and Urine by LC-HRMS: Implications for Antidoping Analysis.Rapid Commun Mass SpectromOther paper2026
Retatrutide Once Weekly for Treatment of Obstructive Sleep Apnea.N Engl J MedOther paper2026
Development and validation of a multiplexed LC-HRMS method for nine GLP-1 receptor agonists and its pharmaceutical application.J Chromatogr AOther paper2026
Retatrutide in adults with obesity and type 2 diabetes: what have we learned from TRIUMPH-2?LancetOther paper2026
Unapproved GLP-1 Drugs Retatrutide and Zenagamtide Sold Online Are No Bargain.JAMAOther paper2026
Self-Reported Adverse Effects Among Social Media Users Taking Nonapproved Retatrutide.JAMA Netw OpenOther paper2026
Retatrutide trial: Triple action jab can cause weight loss of up to 25%, results suggest.BMJOther paper2026
Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity.N Engl J MedOther paper2026
Efficacy and Safety of Dual GLP-1/Glucagon Receptor Agonism in Overweight and Obesity: A Class-Specific Systematic Review and Meta-Analysis.Diabetes Obes MetabOther paper2026
Future GLP-1 receptor co-agonists and their cardiac effects.Naunyn Schmiedebergs Arch PharmacolOther paper2026
Comparative effects of semaglutide tirzepatide and retatrutide on renal fibrosis in UUO and aged mice.iScienceOther paper2026
Incretin-based therapies in diabetic kidney disease: toward integrated cardio-kidney-metabolic disease modification.Kidney Res Clin PractOther paper2026
Comparative efficacy and safety of glucagon-like peptide 1 based drugs for weight loss in adults with overweight or obesity without diabetes: network meta-analysis of randomised controlled trials.BMJ MedOther paper2026
Disease-modifying anti-diabetic drugs (DMADDs): bridging the SIMPLE approach to disease interception.Cardiovasc DiabetolOther paper2026
Retatrutide: Obesity drug opens to "compassionate use" in US after speculation Trump took it.BMJOther paper2026
Integrating glucagon-like peptide-1 receptor agonists into dermatology practice: Safety and monitoring strategies.Clin DermatolOther paper2026
Retatrutide effects on diabetic rats' cognition.Lab Anim (NY)Other paper2026
Retatrutide fact check: Has a man died after taking the unapproved weight loss jab?BMJOther paper2026
A Hydrophobic Tag-Assisted Liquid-Phase Strategy for the Synthesis of Retatrutide.Org LettOther paper2026
Retatrutide: Triple acting jab for type 2 diabetes lowers blood sugar and boosts weight loss, trial reports.BMJOther paper2026
Rationale, design and baseline characteristics of the TRANSCEND-CKD trial of retatrutide in patients with chronic kidney disease.Nephrol Dial TransplantOther paper2026
Kynurenic acid mediates epicardial fat-induced lymphatic metabolic dysfunction in atrial fibrillation.Nat CommunOther paper2026
Triple Hormone Receptor Agonism: The Role of Retatrutide in Addressing Cardiovascular-Kidney-Metabolic (CKM) Syndrome: A Comprehensive Review.Cardiol RevOther paper2026
Multi-omic profiling reveals Retatrutide alleviates adipose tissue fibrosis via metabolic reprogramming and tissue repair.Diabetol Metab SyndrOther paper2026
Incretin-Based Dual and Triple Agonists in Overweight or Obese Individuals: A Systematic Review and Meta-Analysis.Cardiol RevOther paper2026
Development of the Weight and Emotions Scale (WES).Obes Sci PractOther paper2026
[Nephrology : what's new in 2025].Rev Med SuisseOther paper2026
Development and Content Evaluation of the Eating Behavior and Appetite Questionnaire (EBAQ) for Individuals with Obesity.Adv TherOther paper2026
Retatrutide for the treatment of obesity, obstructive sleep apnea and knee osteoarthritis: Rationale and design of the TRIUMPH registrational clinical trials.Diabetes Obes MetabOther paper2026
Inotropic effects of retatrutide in isolated human atrial preparations.Naunyn Schmiedebergs Arch PharmacolOther paper2026
Perceived benefits of treatment for obesity with retatrutide: A qualitative study of patients in a phase 2 clinical trial.Obes PillarsOther paper2025
Strategic Design of Triple GLP-1R/GCGR/GIPR Agonists with Varied Receptor Potency: Achieving Comparable Glycemic and Weight Reduction Effects.J Med ChemOther paper2025
The Effect of Retatrutide on Kidney Parameters in Participants With Type 2 Diabetes Mellitus and/or Obesity.Kidney Int RepOther paper2025
Comparative efficacy and safety of GLP-1 receptor agonists for weight reduction: A model-based meta-analysis of placebo-controlled trials.Obes PillarsOther paper2025
Pharmacological Dissection Identifies Retatrutide Overcomes the Therapeutic Barrier of Obese TNBC Treatments through Suppressing the Interplay between Glycosylation and Ubiquitylation of YAP.Adv Sci (Weinh)Other paper2025
Incretin triple agonist retatrutide (LY3437943) alleviates obesity-associated cancer progression.NPJ Metab Health DisOther paper2025
Compounded glucagon-like peptide-1 receptor agonists for weight loss: the direct-to-consumer market in Colorado.J Pharm Policy PractOther paper2025
The "Weight" for a New Agent Is Almost Over: A Commentary on the Novel Triagonist Retatrutide for Obesity.J Pharm TechnolOther paper2024
Retatrutide.Clin DiabetesOther paper2024
Recent advances in peptide-based therapies for obesity and type 2 diabetes.PeptidesOther paper2024
Advances in obesity pharmacotherapy; learning from metabolic surgery and beyond.MetabolismOther paper2024
At ObesityWeek, More Data and Questions About Semaglutide, Tirzepatide, and Retatrutide.JAMAOther paper2024
The novel GIP, GLP-1 and glucagon receptor agonist retatrutide delays gastric emptying.Diabetes Obes MetabOther paper2023
Triple-Hormone Combination Retatrutide Induces 24% Body Weight Loss.JAMAOther paper2023
Retatrutide: a triple incretin receptor agonist for obesity management.Expert Opin Investig DrugsOther paper2023
Differentiation of human subcutaneous adipocytes and measurement of lipolytic function induced by GIP or LY3437943.STAR ProtocOther paper2023
Is retatrutide (LY3437943), a GLP-1, GIP, and glucagon receptor agonist a step forward in the treatment of diabetes and obesity?Expert Opin Investig DrugsOther paper2023

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Registered studies in people (34)

StudiesStageStatusPeople taking partUpdated
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)Stage 3Running, no new people100002026-10-08
A Master Protocol of Multiple Agents in Adults With Metabolic Dysfunction-Associated Steatotic Liver Disease (SYNERGY-Outcomes)Stage 3Looking for people45002026-10-08
A Study to Evaluate the Effect of Retatrutide on Insulin Secretion and Insulin Sensitivity in Adult Participants With Type 2 Diabetes MellitusStage 1Running, no new people952026-10-06
Effect of Retatrutide Compared With Semaglutide in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Metformin With or Without SGLT2 Inhibitor (TRANSCEND-T2D-2)Stage 3Running, no new people12502026-09-28
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or Overweight and Chronic Low Back PainStage 3Running, no new people5862026-09-25
A Study of Retatrutide (LY3437943) in Participants Who Have Obesity or OverweightStage 3Finished23352026-08-21
Pre-approval Expanded Access of Retatrutide (LY3437943)–Access outside a study–2026-08-06
A Study of Retatrutide (LY3437943) in Participants With Obesity and Cardiovascular DiseaseStage 3Finished19462026-07-30
A Study of Retatrutide (LY3437943) in Participants With Type 2 Diabetes Mellitus Who Have Obesity or OverweightStage 3Finished11522026-07-30
Effect of Retatrutide Compared With Placebo in Participants With Type 2 Diabetes and Moderate or Severe Renal Impairment, With Inadequate Glycemic Control on Basal Insulin, With or Without Metformin and/or SGLT2 Inhibitor (TRANSCEND-T2D-3)Stage 3Running, no new people3202026-07-20
A Study of Retatrutide (LY3437943) Compared to Tirzepatide (LY3298176) in Adults Who Have ObesityStage 3Running, no new people8002026-07-20
A Study to Investigate the Response of Participants With Type 2 Diabetes Mellitus on Once-Weekly Retatrutide to HypoglycemiaStage 1Finished802026-06-18
A Study of Retatrutide (LY3437943) in Participants Without Type 2 Diabetes Who Have Obesity or OverweightStage 3Running, no new people6002026-06-09
A Study of Retatrutide (LY3437943) in Participants With Obesity or OverweightStage 3Running, no new people2502026-04-17
Effect of LY3437943 Versus Placebo in Participants Who Have Obesity or Are OverweightStage 2Looking for people3002026-03-12
Effect of Retatrutide Compared With Placebo in Adult Participants With Type 2 Diabetes and Inadequate Glycemic Control With Diet and Exercise Alone (TRANSCEND-T2D-1)Stage 3Finished5372026-03-05
A Study of Retatrutide (LY3437943) in the Maintenance of Weight Reduction in Individuals With ObesityStage 3Running, no new people6432026-03-03
A Study of Retatrutide (LY3437943) Once Weekly in Participants Who Have Obesity or Overweight and Osteoarthritis of the KneeStage 3Finished4452026-01-21
A Study of Retatrutide (LY3437943) on Renal Function in Participants With Overweight or Obesity and Chronic Kidney Disease With or Without Type 2 DiabetesStage 2Finished1462025-11-25
A Study to Measure Calorie Consumption and Usage in Participants With Obesity Using LY3437943Stage 1Finished852025-09-23
To Investigate the Effect of Retatrutide (LY3437943) on Metoprolol Pharmacokinetics in Healthy ParticipantsStage 1Finished302025-06-05
A Study of LY3437943 in Participants With Impaired and Normal Liver FunctionStage 1Finished432025-04-18
A Study of LY3437943 in Healthy Participants With a High Body Mass IndexStage 1Finished852024-10-01
A Study of LY3437943 in Postmenopausal Female Participants Who Are Overweight or ObeseStage 1Finished462024-07-26
A Research Study Looking at Similarity Between LY3437943 Versions for Different Injection DevicesStage 1Finished572024-03-29
A Study of LY3437943 in Healthy Participants and Participants With Impaired Renal FunctionStage 1Finished292023-10-02
A Study of LY3437943 in Participants Who Have Obesity or Are OverweightStage 2Finished3382023-09-13
A Study of LY3437943 in Chinese Participants With Obesity Or OverweightStage 1Finished322023-08-14
A Study of Carbon-14-Labelled [14C] LY3437943 in Healthy Male ParticipantsStage 1Finished72023-07-05
A Study of LY3437943 in Participants With Type 2 DiabetesStage 2Finished2812023-07-03
A Drug-Drug Interaction (DDI) Study of LY3437943 in Obese ParticipantsStage 1Finished322023-04-18
A Study of LY3437943 in Japanese Participants With Type 2 Diabetes Mellitus (T2DM)Stage 1Finished642022-08-22
A Study of LY3437943 in Participants With Type 2 Diabetes Mellitus (T2DM)Stage 1Finished722021-01-20
A Safety Study of LY3437943 Given as a Single Injection in Healthy ParticipantsStage 1Finished452019-08-06