| Oral ghrelin receptor agonist MK-0677 increases serum insulin-like growth factor 1 in hemodialysis patients: a randomized blinded study.Nephrol Dial Transplant | Random groups | 2018 |
| Growth hormone secretagogue MK-677: no clinical effect on AD progression in a randomized trial.Neurology | Random groups | 2008 |
| The effects of MK-0677, an oral growth hormone secretagogue, in patients with hip fracture.J Am Geriatr Soc | Random groups | 2004 |
| The effect of treatment with the oral growth hormone (GH) secretagogue MK-677 on GH isoforms.Growth Horm IGF Res | Random groups | 2003 |
| Effects of oral administration of ibutamoren mesylate, a nonpeptide growth hormone secretagogue, on the growth hormone-insulin-like growth factor I axis in growth hormone-deficient children.Clin Pharmacol Ther | Random groups | 2001 |
| Effect of alendronate and MK-677 (a growth hormone secretagogue), individually and in combination, on markers of bone turnover and bone mineral density in postmenopausal osteoporotic women.J Clin Endocrinol Metab | Random groups | 2001 |
| Recombinant human IGF-I does not modify the ACTH and cortisol responses to hCRH and hexarelin, a peptidyl GH secretagogue, in humans.J Endocrinol Invest | Random groups | 2001 |
| Oral administration of the growth hormone secretagogue MK-677 increases markers of bone turnover in healthy and functionally impaired elderly adults. The MK-677 Study Group.J Bone Miner Res | Random groups | 1999 |
| Treatment of obese subjects with the oral growth hormone secretagogue MK-677 affects serum concentrations of several lipoproteins, but not lipoprotein(a).J Clin Endocrinol Metab | Random groups | 1999 |
| Discrepancy between serum leptin values and total body fat in response to the oral growth hormone secretagogue MK-677.Clin Endocrinol (Oxf) | Random groups | 1999 |
| Treatment with the oral growth hormone secretagogue MK-677 increases markers of bone formation and bone resorption in obese young males.J Bone Miner Res | Random groups | 1998 |
| Oral administration of growth hormone (GH) releasing peptide-mimetic MK-677 stimulates the GH/insulin-like growth factor-I axis in selected GH-deficient adults.J Clin Endocrinol Metab | Random groups | 1997 |
| Stimulation of the growth hormone (GH)-insulin-like growth factor I axis by daily oral administration of a GH secretogogue (MK-677) in healthy elderly subjects.J Clin Endocrinol Metab | Random groups | 1996 |
| Effects of a 7-day treatment with a novel, orally active, growth hormone (GH) secretagogue, MK-677, on 24-hour GH profiles, insulin-like growth factor I, and adrenocortical function in normal young men.J Clin Endocrinol Metab | Random groups | 1996 |
| Prolonged oral treatment with MK-677, a novel growth hormone secretagogue, improves sleep quality in man.Neuroendocrinology | No random groups | 1997 |
| Spontaneous Splenic Rupture in a Patient With Recent Use of Performance-Enhancing Compounds: A Case Report and Literature Review.Cureus | Case reports | 2026 |
| Hepatotoxicity induced by MK-677.BMJ Case Rep | Case reports | 2025 |
| Reversible Gynecomastia and Hypogonadism Due to Usage of Commercial Performance-Enhancing Supplement Use.JCEM Case Rep | Case reports | 2024 |
| LGD-4033 and MK-677 use impacts body composition, circulating biomarkers, and skeletal muscle androgenic hormone and receptor content: A case report.Exp Physiol | Case reports | 2022 |
| Peptides in urology and sexual medicine: clinical effectiveness, dosing, indications, and safety: a narrative review.Sex Med Rev | Review of studies | 2026 |
| New directions in growth hormone treatment in children.Pediatr Endocrinol Diabetes Metab | Review of studies | 2025 |
| Treatment of Pediatric Growth Hormone Deficiency With Oral Secretagogues Revisited.J Endocr Soc | Review of studies | 2021 |
| Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.Transl Androl Urol | Review of studies | 2020 |
| The Safety and Efficacy of Growth Hormone Secretagogues.Sex Med Rev | Review of studies | 2018 |
| Ghrelin receptor in energy homeostasis and obesity pathogenesis.Prog Mol Biol Transl Sci | Review of studies | 2013 |
| Ghrelin receptor (GHS-R1A) agonists show potential as interventive agents during aging.Ann N Y Acad Sci | Review of studies | 2007 |
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| Orally active growth hormone secretagogues: state of the art and clinical perspectives.Ann Med | Review of studies | 1998 |
| New GH secretagogues and potential usefulness in thalassemia.J Pediatr Endocrinol Metab | Review of studies | 1998 |
| Growth hormone-releasing peptides and their analogs.Front Neuroendocrinol | Review of studies | 1998 |
| Growth hormone-releasing peptides.Eur J Endocrinol | Review of studies | 1997 |
| Growth hormone-releasing hormone and growth hormone-releasing peptide as therapeutic agents to enhance growth hormone secretion in disease and aging.Recent Prog Horm Res | Review of studies | 1997 |
| Acute stress suppresses hunger-driven food seeking through PVN activation: Reversal by anxiolytic drug and ghrelin receptor agonist, with anxiolytic-like effects of refeeding.Neurosci Res | In animals | 2026 |
| Intranasal Delivery of a Ghrelin Mimetic Engages the Brain Ghrelin Signaling System in Mice.Endocrinology | In animals | 2025 |
| GHSR signalling in perinatal phases is involved in liver metabolism at puberty.J Endocrinol | In animals | 2024 |
| Characterization of growth hormone secretagogue small molecule ibutamoren (MK-0677) and its possible metabolites in thoroughbred horses for doping control.Rapid Commun Mass Spectrom | In animals | 2022 |
| Equine metabolism of the growth hormone secretagogue MK-0677 in vitro and in urine and plasma following oral administration.Drug Test Anal | In animals | 2022 |
| Characterization of equine liver microsome-generated metabolites of growth hormone secretagogue small molecule ibutamoren.Rapid Commun Mass Spectrom | In animals | 2021 |
| Brain and kidney GHS-R1a underexpression is associated with changes in renal function and hemodynamics during neurogenic hypertension.Mol Cell Endocrinol | In animals | 2020 |
| Effect of the Orally Active Growth Hormone Secretagogue MK-677 on Somatic Growth in Rats.Yonsei Med J | In animals | 2018 |
| MK-0677, a Ghrelin Agonist, Alleviates Amyloid Beta-Related Pathology in 5XFAD Mice, an Animal Model of Alzheimer's Disease.Int J Mol Sci | In animals | 2018 |
| Thyroid hormone modulates food intake and glycemia via ghrelin secretion in Zucker fatty rats.Drug Res (Stuttg) | In animals | 2014 |
| Hypothalamic gene expression following ghrelin therapy to gastrectomized rodents.Regul Pept | In animals | 2008 |
| Ghrelin and growth hormone secretagogue receptor expression in mice during aging.Endocrinology | In animals | 2007 |
| Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor.Proc Natl Acad Sci U S A | In animals | 2004 |
| Effect of ghrelin and synthetic growth hormone secretagogues in normal and ischemic rat heart.Basic Res Cardiol | In animals | 2003 |
| Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT.J Cell Biol | In animals | 2002 |
| Pharmacological profile of a new orally active growth hormone secretagogue, SM-130686.J Endocrinol | In animals | 2001 |
| Role of endothelial cells in modulation of contractility induced by hexarelin in rat ventricle.Life Sci | In animals | 2001 |
| Hexarelin protects H9c2 cardiomyocytes from doxorubicin-induced cell death.Endocrine | In animals | 2001 |
| The GH secretagogues ipamorelin and GH-releasing peptide-6 increase bone mineral content in adult female rats.J Endocrinol | In animals | 2000 |
| Growth hormone secretagogue activation of the arcuate nucleus and brainstem occurs via a non-noradrenergic pathway.J Neuroendocrinol | In animals | 2000 |
| Identification and characterization of a new growth hormone-releasing peptide receptor in the heart.Circ Res | In animals | 1999 |
| Increases in circulating insulin-like growth factor I levels by the oral growth hormone secretagogue MK-0677 in the beagle are dependent upon pituitary mediation.Endocrinology | In animals | 1999 |
| Insulin-like growth factor-1 and growth hormone (GH) levels in canine cerebrospinal fluid are unaffected by GH or GH secretagogue (MK-0677) administration.Horm Metab Res | In animals | 1999 |
| Synthesis and biological activities of phenyl piperazine-based peptidomimetic growth hormone secretagogues.Bioorg Med Chem Lett | In animals | 1998 |
| The nonpeptide growth hormone secretagogue, MK-0677, activates hypothalamic arcuate nucleus neurons in vivo.J Neuroendocrinol | In animals | 1998 |
| Somatostatin receptor subtype 2 knockout mice are refractory to growth hormone-negative feedback on arcuate neurons.Mol Endocrinol | In animals | 1997 |
| Attenuation of the growth hormone secretagogue induction of Fos protein in the rat arcuate nucleus by central somatostatin action.Neuroendocrinology | In animals | 1997 |
| Repeat administration of the GH secretagogue MK-0677 increases and maintains elevated IGF-I levels in beagles.J Endocrinol | In animals | 1997 |
| MK-0677, a potent, novel, orally active growth hormone (GH) secretagogue: GH, insulin-like growth factor I, and other hormonal responses in beagles.Endocrinology | In animals | 1996 |
| Solubilization and characterization of a growth hormone secretagogue receptor from porcine anterior pituitary membranes.Biochem Biophys Res Commun | In animals | 1996 |
| Identification of a new G-protein-linked receptor for growth hormone secretagogues.Mol Endocrinol | In animals | 1996 |
| Design and biological activities of L-163,191 (MK-0677): a potent, orally active growth hormone secretagogue.Proc Natl Acad Sci U S A | In animals | 1995 |
| Oxindole derivatives as orally active potent growth hormone secretagogues.J Med Chem | In a lab dish | 2001 |
| Peptide Supplements and Their Therapeutic Applications in Sports Medicine.Am J Sports Med | Other paper | 2026 |
| Rapid and harmonized analytical workflow for the determination of peptidic and non-peptidic doping agents in dried and liquid blood matrices.Analyst | Other paper | 2026 |
| Striosomal ghrelin receptor activity controls reward-cost integration.Res Sq | Other paper | 2026 |
| Knowing the minimal detectable dose can facilitate the interpretation of a hair test result: II. Case example with ibutamoren (MK-677), a growth hormone secretagogue.Clin Chim Acta | Other paper | 2026 |
| SARMs, Metabolic Modulators and Growth Hormone Secretagogues in Suspected Illegal Medicines, Bought as Sport Performance Enhancers: A Retro- and Prospective Study Within the GEON.Drug Test Anal | Other paper | 2025 |
| Design, Biological Characterization, and Discovery of Capromorelin Derivatives as Oral Growth Hormone Secretagogue Receptor Type 1a Agonist for the Treatment of Growth Hormone Deficiency.J Med Chem | Other paper | 2025 |
| Investigating the P53-dependent anti-cancer effect of ibutamoren in human cancer cell lines.Basic Clin Pharmacol Toxicol | Other paper | 2025 |
| Detection of the growth hormone secretagogue MK-0677 in equine hair following oral administration.Drug Test Anal | Other paper | 2023 |
| Binding Domain Characterization of Growth Hormone Secretagogue Receptor.J Transl Int Med | Other paper | 2022 |
| A GH Secretagogue Receptor Agonist (LUM-201) Elicits Greater GH Responses than Standard GH Secretagogues in Subjects of a Pediatric GH Deficiency Trial.Horm Res Paediatr | Other paper | 2022 |
| Development and validation of SARMs and metabolic modulators screening in hair using UHPLC-MS/MS: Application to a doping case and first identification of S23 in authentic human hair.J Chromatogr B Analyt Technol Biomed Life Sci | Other paper | 2021 |
| Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren.Nat Commun | Other paper | 2021 |
| Development and validation of liquid chromatography-tandem mass spectrometry method for screening six selective androgen receptor modulators in dietary supplements.Food Addit Contam Part A Chem Anal Control Expo Risk Assess | Other paper | 2021 |
| An in vitro assay approach to investigate the potential impact of different doping agents on the steroid profile.Drug Test Anal | Other paper | 2021 |
| Antiviral activity of sertindole, raloxifene and ibutamoren against transcription and replication-competent Ebola virus-like particles.BMB Rep | Other paper | 2020 |
| Differential functional selectivity and downstream signaling bias of ghrelin receptor antagonists and inverse agonists.FASEB J | Other paper | 2019 |
| Novel domain-selective ACE-inhibiting activity of synthetic growth hormone secretagogues.Pharmacol Res | Other paper | 2012 |
| Growth hormone secretagogues and growth hormone releasing peptides act as orthosteric super-agonists but not allosteric regulators for activation of the G protein Galpha(o1) by the Ghrelin receptor.Mol Pharmacol | Other paper | 2009 |
| Gateways to clinical trials.Methods Find Exp Clin Pharmacol | Other paper | 2009 |
| Gateways to clinical trials.Methods Find Exp Clin Pharmacol | Other paper | 2009 |
| Overlapping binding site for the endogenous agonist, small-molecule agonists, and ago-allosteric modulators on the ghrelin receptor.Mol Pharmacol | Other paper | 2009 |
| Electrophile-induced dearomatizing spirocyclization of N-arylisonicotinamides: a route to spirocyclic piperidines.Org Lett | Other paper | 2008 |
| Impurity profile tracking for active pharmaceutical ingredients: case reports.J Pharm Biomed Anal | Other paper | 2007 |
| Gateways to clinical trials.Methods Find Exp Clin Pharmacol | Other paper | 2006 |
| Nonpeptide and peptide growth hormone secretagogues act both as ghrelin receptor agonist and as positive or negative allosteric modulators of ghrelin signaling.Mol Endocrinol | Other paper | 2005 |
| Evidence against adenosine analogues being agonists at the growth hormone secretagogue receptor.Biochem Pharmacol | Other paper | 2005 |
| Natural (ghrelin) and synthetic (hexarelin) GH secretagogues stimulate H9c2 cardiomyocyte cell proliferation.J Endocrinol | Other paper | 2002 |
| The antiproliferative effect of synthetic peptidyl GH secretagogues in human CALU-1 lung carcinoma cells.Endocrinology | Other paper | 2002 |
| Spiro(indoline-3,4'-piperidine) growth hormone secretagogues as ghrelin mimetics.Bioorg Med Chem Lett | Other paper | 2001 |
| Identification, characterization, and biological activity of specific receptors for natural (ghrelin) and synthetic growth hormone secretagogues and analogs in human breast carcinomas and cell lines.J Clin Endocrinol Metab | Other paper | 2001 |
| Binding of 125I-labeled ghrelin to membranes from human hypothalamus and pituitary gland.J Endocrinol Invest | Other paper | 2001 |
| Adenosine: A partial agonist of the growth hormone secretagogue receptor.Biochem Biophys Res Commun | Other paper | 2000 |
| Growth hormone secretagogue binding sites in peripheral human tissues.J Clin Endocrinol Metab | Other paper | 2000 |
| Adenosine is an agonist of the growth hormone secretagogue receptor.Endocrinology | Other paper | 2000 |
| Specific binding sites for synthetic growth hormone secretagogues in non-tumoral and neoplastic human thyroid tissue.J Endocrinol | Other paper | 2000 |
| Development of analytical and preparative chromatographic separations of novel growth hormone secretagogue compounds.J Chromatogr A | Other paper | 2000 |
| Pharmacological characterisation of a new oral GH secretagogue, NN703.Eur J Endocrinol | Other paper | 1999 |
| Expression of functional growth hormone secretagogue receptors in human pituitary adenomas: polymerase chain reaction, triple in-situ hybridization and cell culture studies.J Neuroendocrinol | Other paper | 1999 |
| A New Orphan Receptor Involved in Pulsatile Growth Hormone Release.Trends Endocrinol Metab | Other paper | 1999 |
| Specific receptors for synthetic GH secretagogues in the human brain and pituitary gland.J Endocrinol | Other paper | 1998 |
| Structural requirements for the activation of the human growth hormone secretagogue receptor by peptide and nonpeptide secretagogues.Mol Endocrinol | Other paper | 1998 |
| Identification of a pituitary growth hormone-releasing peptide (GHRP) receptor subtype by photoaffinity labeling.Endocrinology | Other paper | 1998 |
| Two methods for the measurement of the dissociation pressure of a crystalline hydrate.J Pharm Biomed Anal | Other paper | 1997 |
| Determination of a novel growth hormone secretagogue (MK-677) in human plasma at picogram levels by liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry.J Chromatogr B Biomed Sci Appl | Other paper | 1997 |
| Molecular analysis of rat pituitary and hypothalamic growth hormone secretagogue receptors.Mol Endocrinol | Other paper | 1997 |
| Theodore R. Woodward Award. Age-related decline in growth hormone secretion: clinical significance and potential reversibility.Trans Am Clin Climatol Assoc | Other paper | 1997 |