# LGD-4033

ligandrol · VK5211

https://graded.pl/en/substances/lgd-4033 · Checked: Not yet

Preliminary version. The editors have not finished checking this card, and grades may change.

A SARM still being studied. No such medicine exists, and the Polish sanitary inspectorate lists it as not allowed in supplements.

> This site is for information and education only. It does not promote or encourage the use or purchase of the substances described and is not medical advice. Many are not authorised as medicines and their safety has not been established. We sell nothing and have no ties to sellers. For health decisions, consult a doctor.

## Short answers

### Does LGD-4033 work?

A SARM still being studied. No such medicine exists, and the Polish sanitary inspectorate lists it as not allowed in supplements. Muscle mass: grade B, effect in studies. One 21-day study of 76 healthy men. Body mass without fat rose and fat did not change. We found nothing longer.

### Is LGD-4033 legal?

PL: No approval found. The Polish sanitary inspectorate lists SARMs as not allowed in food supplements. EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). US: No approval. The FDA drug register has no such medicine.

### Is LGD-4033 banned in sport?

Banned in sport, WADA 2026.

### Is LGD-4033 safe?

Serious warning. Two case reports describe severe liver damage with blocked bile flow, confirmed by biopsy.

## What studies show

| | | | |
|---|---|---|---|
| Muscle mass | B | Effect in studies | One 21-day study of 76 healthy men. Body mass without fat rose and fat did not change. We found nothing longer. |

## Studies we have read

- The safety, pharmacokinetics, and effects of LGD-4033, a novel nonsteroidal oral, selective androgen receptor modulator, in healthy young men. (The journals of gerontology. Series A, Biological sciences and medical sciences 2013; Random groups, n=76) https://pubmed.ncbi.nlm.nih.gov/22459616/

## Is it legal

- PL: No approval. No approval found. The Polish sanitary inspectorate lists SARMs as not allowed in food supplements. https://www.gov.pl/web/gis/zespol-do-spraw-suplementow-diety (Checked: Not yet)
- EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet)
- US: No approval. The FDA drug register has no such medicine. https://www.accessdata.fda.gov/scripts/cder/daf/ (Checked: Not yet)

## Doping

Banned in sport, WADA 2026. https://zoek.officielebekendmakingen.nl/trb-2026-25.html

## How much research exists

- Scientific papers: 52
- Studies with random groups: 1
- Registered studies in people: 1
- These are search results. A count shows how much exists, not how good the studies are. 1 Nov 2026.

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Open data: CC BY 4.0, https://creativecommons.org/licenses/by/4.0/