| Pineal-regulating tetrapeptide epitalon improves eye retina condition in retinitis pigmentosa.Neuro Endocrinol Lett | No random groups | 2002 |
| Epitalon and Epithalamin: A Narrative Review of Mechanistic, Preclinical, and Clinical Evidence.Int J Mol Sci | Review of studies | 2026 |
| Synthetic Peptides in Pharmacy Compounding: Analysis of PCAC Recommendations and Industry Safety Standards.Int J Pharm Compd | Review of studies | 2026 |
| Therapeutic peptides in gerontology: mechanisms and applications for healthy aging.Front Aging | Review of studies | 2026 |
| Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.J Am Acad Orthop Surg Glob Res Rev | Review of studies | 2026 |
| Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.Int J Mol Sci | Review of studies | 2025 |
| [Peptidergic regulation of expression of cellular aging marker proteins in buccal epithelium.].Adv Gerontol | Review of studies | 2024 |
| [Peptides and CCL11 and HMGB1 as molecular markers of aging: literature review and own data].Adv Gerontol | Review of studies | 2014 |
| [Morphofunctional and molecular bases of pineal gland aging].Fiziol Cheloveka | Review of studies | 2012 |
| [Characteristics of the pineal gland and thymus relationship in aging].Adv Gerontol | Review of studies | 2011 |
| [Influence of peptides from pineal gland on thymus function at aging].Adv Gerontol | Review of studies | 2010 |
| [The influence of substances revealing geroprotective of spontaneous carcinogenesis in mice].Adv Gerontol | Review of studies | 2004 |
| Peptides and Ageing.Neuro Endocrinol Lett | Review of studies | 2002 |
| Epitalon-activated telomerase enhance bovine oocyte maturation rate and post-thawed embryo development.Life Sci | In animals | 2025 |
| Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro.Aging (Albany NY) | In animals | 2022 |
| Effects of Geroprotectors on Age-Related Changes in Proteolytic Digestive Enzyme Activities at Different Lighting Conditions.Bull Exp Biol Med | In animals | 2015 |
| [Main mechanisms of rhabdomyolysis-caused kidney injury and their correction by organospecific peptides].Biofizika | In animals | 2014 |
| Melatonin and pineal gland peptides are able to correct the impairment of reproductive cycles in rats.Curr Aging Sci | In animals | 2012 |
| Molecular cellular mechanisms of peptide regulation of melatonin synthesis in pinealocyte culture.Bull Exp Biol Med | In animals | 2012 |
| Peptidegic stimulation of differentiation of pineal immune cells.Bull Exp Biol Med | In animals | 2011 |
| [Effect of preparations melatonin and epitalon on the age-related dynamics of thyrotrophic activity of the hypophysis and thyroid gland function in different light regimes].Adv Gerontol | In animals | 2009 |
| Geroprotective effect of ala-glu-asp-gly peptide in male rats exposed to different illumination regimens.Bull Exp Biol Med | In animals | 2008 |
| Comparative analysis of the expression of c-Fos and interleukin-2 proteins in hypothalamus cells during various treatments.Neurosci Behav Physiol | In animals | 2008 |
| [The influence of melatonin and epithalon on blood leukocyte count and leukocyte alkaline phosphatase in rats under different lighting conditions during ontogenesis].Adv Gerontol | In animals | 2008 |
| [The influences of geroprotectors on age-related changes of antioxidant system in rats liver under different light condition].Adv Gerontol | In animals | 2008 |
| [Effects of epithalon and cortagene on immunity and hemostasis in neonatally hypophysectomized chicken and old birds].Adv Gerontol | In animals | 2008 |
| [Investigation of antihypoxic properties of short peptides].Adv Gerontol | In animals | 2008 |
| Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats exposed to different illumination regimes.Bull Exp Biol Med | In animals | 2007 |
| Effects of intranasal administration of epitalon on neuron activity in the rat neocortex.Neurosci Behav Physiol | In animals | 2007 |
| Effects of bioactive tetrapeptides on free-radical processes.Bull Exp Biol Med | In animals | 2007 |
| [Parallel analysis of c-Fos protein and interleukin-2 expression in hypothalamic cells under different influence].Ross Fiziol Zh Im I M Sechenova | In animals | 2007 |
| [The effect of pineal peptide preparations on proliferative activity in organotypic culture of the preoptic hypothalamus area].Adv Gerontol | In animals | 2007 |
| [Circannual rhythms of bone marrow cell composition in animals during aging: the role of pineal factors].Fiziol Zh (1994) | In animals | 2007 |
| [Age-related changes of exercise capacity and some biochemical indices of rat muscles under influence of different light conditions and pineal preparations].Adv Gerontol | In animals | 2007 |
| Antioxidant properties of geroprotective peptides of the pineal gland.Arch Gerontol Geriatr | In animals | 2007 |
| [Comparative study of the effects of melatonin and epitalon on the protracted memory under the shuttle labyrinth test conditions in rats in the course of aging].Eksp Klin Farmakol | In animals | 2006 |
| Production of lymphocyte-activating factors by mouse macrophages during aging and under the effect of short peptides.Bull Exp Biol Med | In animals | 2006 |
| [Intranasal epitalon infusion modulates neuronal activity in the rat neocortex].Ross Fiziol Zh Im I M Sechenova | In animals | 2006 |
| Interleukin-2 concentration in hypothalamic structures of rats receiving peptides during mild stress.Bull Exp Biol Med | In animals | 2006 |
| Effect of the synthetic pineal peptide epitalon on spontaneous carcinogenesis in female C3H/He mice.In Vivo | In animals | 2006 |
| [Effect of age, different light conditions, melatonin, and epitalon on lysosomal proteinase activity in the liver and kidneys of rats].Adv Gerontol | In animals | 2006 |
| [Influence of light regimens, melatonin, and epitalon on amylase activity in the pancreas and small intestine in rats of different age].Adv Gerontol | In animals | 2006 |
| Synthesis of IL-2 mRNA in cells of rat hypothalamic structures after injection of short peptides.Bull Exp Biol Med | In animals | 2005 |
| Fluorescent microscopic study of epithalon binding in maternal and fetal rabbit tissues in health and under conditions of placental insufficiency.Bull Exp Biol Med | In animals | 2005 |
| [Effect of epitalon and melatonin on life span and spontaneous carcinogenesis in senescence accelerated mice (SAM)].Vopr Onkol | In animals | 2005 |
| Pineal peptides restore the age-related disturbances in hormonal functions of the pineal gland and the pancreas.Exp Gerontol | In animals | 2005 |
| Effect of melatonin and tetrapeptide on gene expression in mouse brain.Bull Exp Biol Med | In animals | 2004 |
| Stressors and antistressors: how do they influence life span in HER-2/neu transgenic mice?Exp Gerontol | In animals | 2004 |
| Peptide correction of age-related hormonal dysfunction of the pancreas in monkeys.Bull Exp Biol Med | In animals | 2004 |
| Effects of bioactive factors of the pineal gland on thymus function and cell composition of the bone marrow and spleen in mice of different age.Bull Exp Biol Med | In animals | 2004 |
| Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray.Neuro Endocrinol Lett | In animals | 2004 |
| [Effect of epitalon on the immunity and hemostasis in hypophysectomized chicken and old hens].Adv Gerontol | In animals | 2004 |
| [The pineal gland's peptides factors and the rhythms of functions of the thymus and bone marrow in animals during aging].Adv Gerontol | In animals | 2004 |
| Epitalon and colon carcinogenesis in rats: proliferative activity and apoptosis in colon tumors and mucosa.Int J Mol Med | In animals | 2003 |
| Effect of regulatory peptides on gene transcription.Bull Exp Biol Med | In animals | 2003 |
| [Peptide correction of age-related pineal disturbances in monkeys].Adv Gerontol | In animals | 2003 |
| [Regulating effect of pineal gland peptides on development of T-lymphocytes in CBA aging mice: role of microenvironment of immune system organs and neuroendocrine factors].Adv Gerontol | In animals | 2003 |
| Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice.Biogerontology | In animals | 2003 |
| Effect of vilon and epithalon on activity of enzymes in epithelial and subepithelial layers in small intestine of old rats.Bull Exp Biol Med | In animals | 2002 |
| Epitalon influences pineal secretion in stress-exposed rats in the daytime.Neuro Endocrinol Lett | In animals | 2002 |
| Effect of epitalon on interleukin-1beta signal transduction and the reaction of thymocyte blast transformation under stress.Neuro Endocrinol Lett | In animals | 2002 |
| Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats.Cancer Lett | In animals | 2002 |
| Inhibitory effect of the peptide epitalon on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.Int J Cancer | In animals | 2002 |
| Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice.Bull Exp Biol Med | In animals | 2002 |
| In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes.Bull Exp Biol Med | In animals | 2002 |
| Effects of short peptides on thymocyte blast transformation and signal transduction along the sphingomyelin pathway.Bull Exp Biol Med | In animals | 2002 |
| Effect of Vilon and Epithalon on glucose and glycine absorption in various regions of small intestine in aged rats.Bull Exp Biol Med | In animals | 2002 |
| Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology.Bull Exp Biol Med | In animals | 2002 |
| Effects of epithalon on activities gastrointestinal enzymes in young and old rats.Bull Exp Biol Med | In animals | 2002 |
| Effect of epithalon on the incidence of chromosome aberrations in senescence-accelerated mice.Bull Exp Biol Med | In animals | 2002 |
| Epithalon inhibits tumor growth and expression of HER-2/neu oncogene in breast tumors in transgenic mice characterized by accelerated aging.Bull Exp Biol Med | In animals | 2002 |
| Effect of epithalon on age-specific changes in the retina in rats with hereditary pigmentary dystrophy.Bull Exp Biol Med | In animals | 2002 |
| [Functional regulation of genome with peptide bioregulators by hypertrophic cardiomyopathy (by patients and relatives)].Georgian Med News | In a lab dish | 2013 |
| [Biological activity of regulatory peptides in model experiments in vitro].Adv Gerontol | In a lab dish | 2008 |
| [Effect of new peptide bioregulators livagen and epitalon on enkephalin-degrading enzymes in human serum].Izv Akad Nauk Ser Biol | In a lab dish | 2003 |
| Effects of peptides on proliferative activity of retinal and pigmented epithelial cells.Bull Exp Biol Med | In a lab dish | 2003 |
| [Tissue-specific action of peptides in tissue culture of rats of various ages].Adv Gerontol | In a lab dish | 2002 |
| Tissue-specific effects of peptides.Bull Exp Biol Med | In a lab dish | 2001 |
| LCP2 mediates SUV39H1-driven cellular senescence-related chemoresistance in natural killer/T-cell lymphoma.Cell Death Dis | Other paper | 2026 |
| Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.Biogerontology | Other paper | 2025 |
| The Antioxidant Tetrapeptide Epitalon Enhances Delayed Wound Healing in an in Vitro Model of Diabetic Retinopathy.Stem Cell Rev Rep | Other paper | 2025 |
| EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON THE "OLD" CHROMATIN.Georgian Med News | Other paper | 2023 |
| Peptides Regulating Proliferative Activity and Inflammatory Pathways in the Monocyte/Macrophage THP-1 Cell Line.Int J Mol Sci | Other paper | 2022 |
| Short Peptides Protect Oral Stem Cells from Ageing.Stem Cell Rev Rep | Other paper | 2020 |
| AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis: Possible Epigenetic Mechanism.Molecules | Other paper | 2020 |
| [The influence of AEDG and KE peptides on mitochondries stain and L7A ribosomes protein expression during human pineal gland and thymus cell senescence in vitro.].Adv Gerontol | Other paper | 2020 |
| [AEDG peptide regulates human circadian rhythms genes expression during pineal gland accelerated aging.].Adv Gerontol | Other paper | 2020 |
| Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum.Biochemistry (Mosc) | Other paper | 2017 |
| [Genome instability in pulmonary tuberculosis before and after treatment].Georgian Med News | Other paper | 2013 |
| [Protective effect of melatonin and epithalon on hypothalamic regulation of reproduction in female rats in its premature aging model and on estrous cycles in senescent animals in various lighting regimes].Adv Gerontol | Other paper | 2013 |
| Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.Biochemistry (Mosc) | Other paper | 2011 |
| [The effect of heavy metal ions and peptide bioregulators on the expression of chromosome fragile sites in the individuals of different age groups and breast cancer patients].Georgian Med News | Other paper | 2008 |
| [Normalizing effect of the pineal gland peptides on the daily melatonin rhythm in old monkeys and elderly people].Adv Gerontol | Other paper | 2007 |
| Anti-aging peptide bioregulators induce reactivation of chromatin.Georgian Med News | Other paper | 2006 |
| DNA double-helix binds regulatory peptides similarly to transcription factors.Neuro Endocrinol Lett | Other paper | 2005 |
| Expression of argyrophilic proteins in the nucleolar organizer regions of human thymocytes and thymic epitheliocytes under conditions of coculturing with vilon and epithalon peptides.Bull Exp Biol Med | Other paper | 2004 |
| Peptide promotes overcoming of the division limit in human somatic cell.Bull Exp Biol Med | Other paper | 2004 |
| Effects of short peptides on lymphocyte chromatin in senile subjects.Bull Exp Biol Med | Other paper | 2004 |
| Peptide Epitalon activates chromatin at the old age.Neuro Endocrinol Lett | Other paper | 2003 |
| Gateways to clinical trials.Methods Find Exp Clin Pharmacol | Other paper | 2003 |
| Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells.Bull Exp Biol Med | Other paper | 2003 |
| The role of pineal gland in breast cancer development.Crit Rev Oncol Hematol | Other paper | 2003 |
| Retinoprotective effect of Epithalon in campbell rats of various ages.Bull Exp Biol Med | Other paper | 2003 |