# Epitalon

epithalon · Ala-Glu-Asp-Gly · AEDG

https://graded.pl/en/substances/epitalon · Checked: Not yet

Preliminary version. The editors have not finished checking this card, and grades may change.

A synthetic peptide based on a pineal gland extract. No studies with random groups and no approved medicine in the EU or US.

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## Short answers

### Does epitalon work?

A synthetic peptide based on a pineal gland extract. No studies with random groups and no approved medicine in the EU or US. Longer life: grade D, not clear. Fruit flies lived 11% to 16% longer. There are no studies with random groups in people.

### Is Epitalon legal?

PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). US: No approval. No approved medicine. On 30 October 2026 the US health department (HHS) published a draft policy: it does not plan to act against pharmacies and doctors that make it on a prescription for a named patient, from an FDA-registered maker, until the FDA decides by rule. The draft is not binding, and comments close on 13 November 2026.

### Is epitalon banned in sport?

May be banned, WADA 2026. It is not on the WADA list, but WADA also bans substances that no health authority has approved, so it may be banned.

### Is Epitalon safe?

Not known. There are no studies with random groups, and we found no safety study in people.

## What studies show

| | | | |
|---|---|---|---|
| Longer life | D | Not clear | Fruit flies lived 11% to 16% longer. There are no studies with random groups in people. |

## Studies we have read

- Effect of epitalon on the lifespan increase in Drosophila melanogaster. (Mechanisms of ageing and development 2000; In animals) https://pubmed.ncbi.nlm.nih.gov/11087911/

## Is it legal

- PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet)
- EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet)
- US: No approval. No approved medicine. On 30 October 2026 the US health department (HHS) published a draft policy: it does not plan to act against pharmacies and doctors that make it on a prescription for a named patient, from an FDA-registered maker, until the FDA decides by rule. The draft is not binding, and comments close on 13 November 2026. https://www.federalregister.gov/documents/2026/10/30/2026-22192/enforcement-discretion-policy-regarding-503a-compounding-using-certain-peptide-bulk-drug-substances (Checked: Not yet)

## Doping

May be banned, WADA 2026. https://zoek.officielebekendmakingen.nl/trb-2026-25.html

## How much research exists

- Scientific papers: 123
- Studies with random groups: 0
- Registered studies in people: 1
- These are search results. A count shows how much exists, not how good the studies are. 1 Nov 2026.

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Open data: CC BY 4.0, https://creativecommons.org/licenses/by/4.0/