# Cardarine

GW501516 · GW1516 · endurobol

https://graded.pl/en/substances/cardarine · Checked: Not yet

Preliminary version. The editors have not finished checking this card, and grades may change.

A substance that affects how the body uses fat (GW501516). Work on it as a medicine was stopped. No such medicine exists.

> This site is for information and education only. It does not promote or encourage the use or purchase of the substances described and is not medical advice. Many are not authorised as medicines and their safety has not been established. We sell nothing and have no ties to sellers. For health decisions, consult a doctor.

## Short answers

### Does cardarine work?

A substance that affects how the body uses fat (GW501516). Work on it as a medicine was stopped. No such medicine exists. Fat loss: grade C, not clear. In a 2-week study with random groups of 6 people each, liver fat fell by 20%. Nobody measured body fat or weight loss. Work on it as a medicine stopped after cancer findings in mice.

### Is Cardarine legal?

PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). US: No approval. The FDA drug register has no such medicine.

### Is cardarine banned in sport?

Banned in sport, WADA 2026.

### Is Cardarine safe?

Serious warning. In mice with a KRAS gene change, GW501516 sped up the path from early lesions to pancreatic cancer. This is an animal result, and work on it as a medicine for people has stopped.

## What studies show

| | | | |
|---|---|---|---|
| Fat loss | C | Not clear | In a 2-week study with random groups of 6 people each, liver fat fell by 20%. Nobody measured body fat or weight loss. Work on it as a medicine stopped after cancer findings in mice. |

## Studies we have read

- Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men. (Diabetes 2008; Random groups, n=18) https://pubmed.ncbi.nlm.nih.gov/18024853/
- Triglyceride:high-density lipoprotein cholesterol effects in healthy subjects administered a peroxisome proliferator activated receptor delta agonist. (Arterioscler Thromb Vasc Biol 2007; Random groups, n=24) https://pubmed.ncbi.nlm.nih.gov/17110604/

## Is it legal

- PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet)
- EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet)
- US: No approval. The FDA drug register has no such medicine. https://www.accessdata.fda.gov/scripts/cder/daf/ (Checked: Not yet)

## Doping

Banned in sport, WADA 2026. https://zoek.officielebekendmakingen.nl/trb-2026-25.html

## How much research exists

- Scientific papers: 318
- Studies with random groups: 4
- Registered studies in people: 3
- These are search results. A count shows how much exists, not how good the studies are. 1 Nov 2026.

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Open data: CC BY 4.0, https://creativecommons.org/licenses/by/4.0/