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| Allopurinol Treatment Improves Cognitive Skills, Adaptive Behavior, and Biochemical Markers in Young Patients With Adenylosuccinate Lyase Deficiency.J Inherit Metab Dis | No random groups | 2025 |
| Traumatic Injury and Exposure to Mitochondrial-Derived Damage Associated Molecular Patterns Suppresses Neutrophil Extracellular Trap Formation.Front Immunol | No random groups | 2019 |
| Urine levels of 5-aminoimidazole-4-carboxamide riboside (AICAR) in patients with type 2 diabetes.Acta Diabetol | No random groups | 2018 |
| Regulation of autophagy in human skeletal muscle: effects of exercise, exercise training and insulin stimulation.J Physiol | No random groups | 2016 |
| AICAR administration affects glucose metabolism by upregulating the novel glucose transporter, GLUT8, in equine skeletal muscle.Vet J | No random groups | 2015 |
| Role of AMPK in UVB-induced DNA damage repair and growth control.Oncogene | No random groups | 2013 |
| Acadesine for patients with relapsed/refractory chronic lymphocytic leukemia (CLL): a multicenter phase I/II study.Cancer Chemother Pharmacol | No random groups | 2013 |
| Skeletal muscle NAMPT is induced by exercise in humans.Am J Physiol Endocrinol Metab | No random groups | 2010 |
| Intravenous AICAR administration reduces hepatic glucose output and inhibits whole body lipolysis in type 2 diabetic patients.Diabetologia | No random groups | 2008 |
| 13C-enrichment at carbons 8 and 2 of uric acid after 13C-labeled folate dose in man.Biochem Biophys Res Commun | No random groups | 2007 |
| 5-aminoimidazole-4-carboxamide 1-beta-D-ribofuranoside acutely stimulates skeletal muscle 2-deoxyglucose uptake in healthy men.Diabetes | No random groups | 2007 |
| Metformin improves atypical protein kinase C activation by insulin and phosphatidylinositol-3,4,5-(PO4)3 in muscle of diabetic subjects.Diabetologia | No random groups | 2006 |
| Acute IL-6 treatment increases fatty acid turnover in elderly humans in vivo and in tissue culture in vitro.Am J Physiol Endocrinol Metab | No random groups | 2005 |
| Beta-adrenergic stimulation of skeletal muscle HSL can be overridden by AMPK signaling.FASEB J | No random groups | 2004 |
| Effect of methotrexate on blood purine and pyrimidine levels in patients with rheumatoid arthritis.Rheumatology (Oxford) | No random groups | 1999 |
| Effect of acadesine on myocardial ischaemia in patients with coronary artery disease.Eur J Pharmacol | No random groups | 1997 |
| Electrocardiographic and hemodynamic changes and their association with myocardial infarction during coronary artery bypass surgery. A multicenter study. Multicenter Study of Perioperative Ischemia (McSPI) Research Group.Anesthesiology | No random groups | 1997 |
| Case report of a rare purine synthesis disorder due to 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (AICAR) deficiency.Brain Dev | Case reports | 2022 |
| Is Pharmacogenetic Panel Testing Applicable to Low-Dose Methotrexate in Rheumatoid Arthritis? - A Case Report.Pharmgenomics Pers Med | Case reports | 2022 |
| AICA-ribosiduria due to ATIC deficiency: Delineation of the phenotype with three novel cases, and long-term update on the first case.J Inherit Metab Dis | Case reports | 2020 |
| Very mild isolated intellectual disability caused by adenylosuccinate lyase deficiency: a new phenotype.Mol Genet Metab Rep | Case reports | 2020 |
| Broadening phenotype of adenylosuccinate lyase deficiency: A novel clinical pattern resembling neuronal ceroid lipofuscinosis.Mol Genet Metab Rep | Case reports | 2019 |
| Diagnosis of adenylosuccinate lyase deficiency by metabolomic profiling in plasma reveals a phenotypic spectrum.Mol Genet Metab Rep | Case reports | 2016 |
| AICA-ribosiduria: a novel, neurologically devastating inborn error of purine biosynthesis caused by mutation of ATIC.Am J Hum Genet | Case reports | 2004 |
| Treatment of Lesch-Nyhan syndrome with AICAR.Adv Exp Med Biol | Case reports | 1994 |
| The central role of macrophages in skeletal muscle regeneration: Phenotypic Polarization, metabolic reprogramming, and therapeutic prospects.Biochem Pharmacol | Review of studies | 2026 |
| AMPK as a central regulator of metabolic memory: mechanisms and therapeutic opportunities.J Diabetes Metab Disord | Review of studies | 2026 |
| Targeting AMPK Networks for Male Reproductive Health: Mechanisms and Emerging Therapies.Cells | Review of studies | 2026 |
| When is a sample a urine sample? Markers for urine sample authenticity assessment in sports drug testing.Bioanalysis | Review of studies | 2025 |
| Purine Nucleotide Precursors in Preventing Myocardial Ischemia-Reperfusion Injury.Int J Mol Sci | Review of studies | 2025 |
| Exploring Cirrhosis: Insights into Advances in Therapeutic Strategies.Int J Mol Sci | Review of studies | 2025 |
| Purine Chemistry in the Early RNA World at the Origins of Life: From RNA and Nucleobases Lesions to Current Key Metabolic Routes.Chembiochem | Review of studies | 2025 |
| The diagnosis and treatment of disorders of nucleic acid/nucleotide metabolism associated with epilepsy.Acta Epileptol | Review of studies | 2025 |
| AMPK: The energy sensor at the crossroads of aging and cancer.Semin Cancer Biol | Review of studies | 2024 |
| Targeting AMP-activated protein kinase in sepsis.Front Endocrinol (Lausanne) | Review of studies | 2024 |
| 5'AMP-activated protein kinase: an emerging target of phytochemicals to treat chronic inflammatory diseases.Crit Rev Food Sci Nutr | Review of studies | 2024 |
| Mitochondria-derived peptide MOTS-c: effects and mechanisms related to stress, metabolism and aging.J Transl Med | Review of studies | 2023 |
| MOTS-c Functionally Prevents Metabolic Disorders.Metabolites | Review of studies | 2023 |
| Modulation of hypothalamic AMPK and hypothalamic neuropeptides in the control of eating behavior: A systematic review.Life Sci | Review of studies | 2022 |
| GDF15 in Appetite and Exercise: Essential Player or Coincidental Bystander?Endocrinology | Review of studies | 2022 |
| AICAr, a Widely Used AMPK Activator with Important AMPK-Independent Effects: A Systematic Review.Cells | Review of studies | 2021 |
| Autophagy in the physiological endometrium and cancer.Autophagy | Review of studies | 2021 |
| Rosmarinic acid improves boar sperm quality, antioxidant capacity and energy metabolism at 17°C via AMPK activation.Reprod Domest Anim | Review of studies | 2020 |
| Autophagy modulation in animal models of corneal diseases: a systematic review.Mol Cell Biochem | Review of studies | 2020 |
| Vascular adenosine monophosphate-activated protein kinase: Enhancer, brake or both?Basic Clin Pharmacol Toxicol | Review of studies | 2020 |
| Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics.Int J Mol Sci | Review of studies | 2020 |
| The Role of AMPK Activation for Cardioprotection in Doxorubicin-Induced Cardiotoxicity.Cardiovasc Drugs Ther | Review of studies | 2020 |
| [Advances on the anti-inflammatory and protective effect of AMPK activators].Sheng Li Xue Bao | Review of studies | 2019 |
| In vitro experimental models for examining the skeletal muscle cell biology of exercise: the possibilities, challenges and future developments.Pflugers Arch | Review of studies | 2019 |
| Targeting AMPK in Diabetes and Diabetic Complications: Energy Homeostasis, Autophagy and Mitochondrial Health.Curr Med Chem | Review of studies | 2019 |
| The Role of AMPK/mTOR Modulators in the Therapy of Acute Myeloid Leukemia.Curr Med Chem | Review of studies | 2019 |
| Modulation of the de novo purine nucleotide pathway as a therapeutic strategy in mitochondrial myopathy.Pharmacol Res | Review of studies | 2018 |
| The Role of AMPK in the Regulation of Skeletal Muscle Size, Hypertrophy, and Regeneration.Int J Mol Sci | Review of studies | 2018 |
| AMP-Activated Protein (AMPK) in Pathophysiology of Pregnancy Complications.Int J Mol Sci | Review of studies | 2018 |
| Interplay between adenylate metabolizing enzymes and AMP-activated protein kinase.FEBS J | Review of studies | 2018 |
| Linking energy sensing to suppression of JAK-STAT signalling: A potential route for repurposing AMPK activators?Pharmacol Res | Review of studies | 2018 |
| Pharmacological targeting of exercise adaptations in skeletal muscle: Benefits and pitfalls.Biochem Pharmacol | Review of studies | 2018 |
| Modulating Mitophagy in Mitochondrial Disease.Curr Med Chem | Review of studies | 2018 |
| Exercise in a Pill: The Latest on Exercise-Mimetics.Brain Plast | Review of studies | 2017 |
| Controls of Nuclear Factor-Kappa B Signaling Activity by 5'-AMP-Activated Protein Kinase Activation With Examples in Human Bladder Cancer Cells.Int Neurourol J | Review of studies | 2016 |
| HGSD attenuates neuronal apoptosis through enhancing neuronal autophagy in the brain of diabetic mice: The role of AMP-activated protein kinase.Life Sci | Review of studies | 2016 |
| Caloric restriction and exercise "mimetics'': Ready for prime time?Pharmacol Res | Review of studies | 2016 |
| Targeting autophagy and mitophagy for mitochondrial diseases treatment.Expert Opin Ther Targets | Review of studies | 2016 |
| Blockade of MerTK Activation by AMPK Inhibits RPE Cell Phagocytosis.Adv Exp Med Biol | Review of studies | 2016 |
| Activation of AMPK and its Impact on Exercise Capacity.Sports Med | Review of studies | 2015 |
| Folate-Dependent Purine Nucleotide Biosynthesis in Humans.Adv Nutr | Review of studies | 2015 |
| Metabolic modulators of the exercise response: doping control analysis of an agonist of the peroxisome proliferator-activated receptor δ (GW501516) and 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR).J Physiol Pharmacol | Review of studies | 2014 |
| Perspectives of drug-based neuroprotection targeting mitochondria.Rev Neurol (Paris) | Review of studies | 2014 |
| Turn up the power - pharmacological activation of mitochondrial biogenesis in mouse models.Br J Pharmacol | Review of studies | 2014 |
| Methotrexate: new uses for an old drug.J Pediatr | Review of studies | 2014 |
| New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia.Cell Signal | Review of studies | 2014 |
| Wnt signaling in liver fibrosis: progress, challenges and potential directions.Biochimie | Review of studies | 2013 |
| AMP-activated protein kinase at the nexus of therapeutic skeletal muscle plasticity in Duchenne muscular dystrophy.Trends Mol Med | Review of studies | 2013 |
| From gene engineering to gene modulation and manipulation: can we prevent or detect gene doping in sports?Sports Med | Review of studies | 2013 |
| Molecular mechanisms and signaling pathways of angiotensin II-induced muscle wasting: potential therapeutic targets for cardiac cachexia.Int J Biochem Cell Biol | Review of studies | 2013 |
| Fibroblast growth factor-21 is a promising dietary restriction mimetic.Rejuvenation Res | Review of studies | 2012 |
| Targeting the liver kinase B1/AMP-activated protein kinase pathway as a therapeutic strategy for hematological malignancies.Expert Opin Ther Targets | Review of studies | 2012 |
| Ion channel regulation by the LKB1-AMPK signalling pathway: the key to carotid body activation by hypoxia and metabolic homeostasis at the whole body level.Adv Exp Med Biol | Review of studies | 2012 |
| AMP-activated protein kinase and the control of smooth muscle cell hyperproliferation in vascular disease.Vascul Pharmacol | Review of studies | 2012 |
| AMPK in BCR-ABL expressing leukemias. Regulatory effects and therapeutic implications.Oncotarget | Review of studies | 2011 |
| Insulin resistance due to nutrient excess: is it a consequence of AMPK downregulation?Cell Cycle | Review of studies | 2011 |
| LKB1/AMPK/mTOR signaling pathway in hematological malignancies: from metabolism to cancer cell biology.Cell Cycle | Review of studies | 2011 |
| Novel trends in the treatment of cardiovascular disorders: site- and event- selective adenosinergic drugs.Curr Med Chem | Review of studies | 2011 |
| AICA-riboside (acadesine), an activator of AMP-activated protein kinase with potential for application in hematologic malignancies.Expert Opin Investig Drugs | Review of studies | 2010 |
| Evidence for the hypothesis that 10-formyldihydrofolate is the in vivo substrate for aminoimidazolecarboxamide ribotide transformylase.Exp Biol Med (Maywood) | Review of studies | 2010 |
| Acadesine, an adenosine-regulating agent with the potential for widespread indications.Expert Opin Pharmacother | Review of studies | 2008 |
| LKB1 and AMPK and the regulation of skeletal muscle metabolism.Curr Opin Clin Nutr Metab Care | Review of studies | 2008 |
| The role of AMP kinase in diabetes.Indian J Med Res | Review of studies | 2007 |
| AMP-activated protein kinase and the regulation of glucose transport.Am J Physiol Endocrinol Metab | Review of studies | 2006 |
| Past and future approaches to ischemia-reperfusion lesion associated with liver transplantation.Life Sci | Review of studies | 2006 |
| AMP-activated protein kinase and type 2 diabetes.Curr Med Chem | Review of studies | 2006 |
| Sending the signal: molecular mechanisms regulating glucose uptake.Med Sci Sports Exerc | Review of studies | 2004 |
| Role of calcium and AMP kinase in the regulation of mitochondrial biogenesis and GLUT4 levels in muscle.Proc Nutr Soc | Review of studies | 2004 |
| Transgenic models--a scientific tool to understand exercise-induced metabolism: the regulatory role of AMPK (5'-AMP-activated protein kinase) in glucose transport and glycogen synthase activity in skeletal muscle.Biochem Soc Trans | Review of studies | 2003 |
| Minireview: malonyl CoA, AMP-activated protein kinase, and adiposity.Endocrinology | Review of studies | 2003 |
| AMPK as a metabolic switch in rat muscle, liver and adipose tissue after exercise.Acta Physiol Scand | Review of studies | 2003 |
| The role of intramuscular lipid in insulin resistance.Acta Physiol Scand | Review of studies | 2003 |
| AMP-activated protein kinase and muscle glucose uptake.Acta Physiol Scand | Review of studies | 2003 |
| Selective suppression of AMP-activated protein kinase in skeletal muscle: update on 'lazy mice'.Biochem Soc Trans | Review of studies | 2003 |
| A possible role for AMP-activated protein kinase in exercise-induced glucose utilization: insights from humans and transgenic animals.Biochem Soc Trans | Review of studies | 2003 |
| Pemetrexed in pancreatic cancer.Semin Oncol | Review of studies | 2002 |
| Targeting the AMP-activated protein kinase for the treatment of type 2 diabetes.Curr Drug Targets Immune Endocr Metabol Disord | Review of studies | 2002 |
| Hyperglycemia and insulin resistance: possible mechanisms.Ann N Y Acad Sci | Review of studies | 2002 |
| Metabolism of 10-formyldihydrofolate in humans.Biomed Pharmacother | Review of studies | 2001 |
| Pemetrexed disodium: a novel antifolate clinically active against multiple solid tumors.Oncologist | Review of studies | 2001 |
| AMP-activated protein kinase: possible target for treatment of type 2 diabetes.Diabetes Technol Ther | Review of studies | 2000 |
| Acadesine during fluid resuscitation from shock and abdominal sepsis.Crit Care Med | Review of studies | 1999 |
| Cardiopulmonary bypass-induced inflammation: is it important?J Cardiothorac Vasc Anesth | Review of studies | 1998 |
| Inborn errors of the purine nucleotide cycle: adenylosuccinase deficiency.J Inherit Metab Dis | Review of studies | 1997 |
| Harnessing an endogenous cardioprotective mechanism: cellular sources and sites of action of adenosine.J Mol Cell Cardiol | Review of studies | 1995 |
| Harnessing nature's own cardiac defense mechanism with acadesine, an adenosine regulating agent: importance of the endothelium.J Card Surg | Review of studies | 1994 |
| Acadesine: preclinical overview.Adv Exp Med Biol | Review of studies | 1994 |
| Acadesine: the prototype adenosine regulating agent for reducing myocardial ischaemic injury.Cardiovasc Res | Review of studies | 1993 |
| Bilirubin impacts microglial lipophagy via the AMPK-mTOR signaling pathway.Neurochem Int | In animals | 2026 |
| [Jiaotaiwan improves lipid metabolism abnormalities in a mouse model of Alzheimer disease by regulating the AMPK signaling pathway].Nan Fang Yi Ke Da Xue Xue Bao | In animals | 2026 |
| Hyperglycemia-Induced Loss of Astrocytic Kir4.1 Is Associated with Increased DNMT1 Activity and Altered AMPK/SIRT1 Signaling.Cells | In animals | 2026 |
| Sirt3 deficiency impairs AMPK-Acc1 antilipogenic signaling in female adipocytes.Mol Biol Rep | In animals | 2026 |
| GPR75 knockdown alleviates mitochondrial dysfunction in retinal ganglion cells via AMPK pathway in diabetic mice.Biochem Pharmacol | In animals | 2026 |
| The AMPK-PGC-1α-SIRT3 axis mediates mitochondrial metabolic dysfunction and neuronal senescence induced by Al(mal)3 exposure in HT22 hippocampal neuronal cells.Free Radic Biol Med | In animals | 2026 |
| High-Calorie Diet Aggravates Lipopolysaccharide-Induced Pulmonary Inflammation in Juvenile Mice: Association of Acetate-Mediated Macrophage Polarization with AMPK/YAP Signaling.Nutrients | In animals | 2026 |
| FGF21 attenuates sepsis-induced myocardial injury via AMPK-mediated mitochondrial biogenesis.Biochem Biophys Res Commun | In animals | 2026 |
| LKB1/ AMPK deficiency aggravates mitochondrial DNA leakage via mTOR-dependent mitophagy damage in liver injury sensitized by trichloroethylene.Chem Biol Interact | In animals | 2026 |
| AMPK/ULK1 enhances mitophagy and steroidogenesis in duck Granulosa cells under heat exposure.Poult Sci | In animals | 2026 |
| Gonadotropin-inhibitory hormone (GnIH) induces glycolipid metabolic dysfunction in porcine ovarian granulosa cells via Wnt and AMPK signaling pathways.Mol Cell Endocrinol | In animals | 2026 |
| Exercise Preconditioning Activates AMPK-ACC Signaling and Attenuates Myocardial Ischemia/Reperfusion-Induced Ferroptosis.J Cardiovasc Transl Res | In animals | 2026 |
| Hypoglycemic conditions enhance neonatal β-cell glucose responsiveness via AMPK/mTOR-increased KATP channel density.Endocrinology | In animals | 2026 |
| MiR-27b-3p suppresses proliferation and testosterone synthesis in goat Leydig cells by activating the AMPK pathway through PPARG targeting.Anim Reprod Sci | In animals | 2026 |
| SS31 protects damaged retinal cells through the AMPK/DRP1 signaling pathway.Mol Vis | In animals | 2026 |
| Ketamine ameliorates postpartum depression-like behaviors in rats exposed to sevoflurane during pregnancy through the AMPK/SIRT1/NLRP3 pathway.J Affect Disord | In animals | 2026 |
| Energy Stress-Induced Neuroprotection Against Ferroptosis in Dopaminergic Neurons.J Neurochem | In animals | 2026 |
| AICAR improves depression-like behaviors and is associated with hippocampal AMPK activation and modulation of neurogenesis and neuroinflammation in a microbiota disruption model.Neurochem Int | In animals | 2026 |
| Melanocyte proliferation gene 1 regulated metabolic reprogramming in acute myocardial infarction based on the AMPK/mTOR pathway.Toxicol Appl Pharmacol | In animals | 2026 |
| Sophocarpine prevents LPS and IFN-γ-stimulated oxidative stress and neuroinflammation of BV-2 microglia by regulating the AMPK/NF-κB signaling pathway.Neurol Res | In animals | 2026 |
| A nutrient-responsive AMPK/TBK1 circuit restricts adipocyte catabolism.JCI Insight | In animals | 2026 |
| Metformin Alleviates Cadmium-Induced Autophagic Flux Impairment-Dependent Apoptosis by Activating AMPK in Neuronal Cells.Cells | In animals | 2026 |
| Kaempferol alleviates right ventricular hypertrophy in high-altitude pulmonary hypertension rats by modulating the AMPK/ACC/CPT1B axis and the AMPK-mediated LDHA/PDHA1 pathway.Food Funct | In animals | 2026 |
| Sacubitril/Valsartan Ameliorates Inflammation and Oxidative Stress in Hypertensive Heart Disease by Upregulating CAMKK2 Protein and Modulating the AMPK/AKT/GSK-3β Axis.Kaohsiung J Med Sci | In animals | 2026 |
| Exercise-Induced Differential Transcriptional Output of AMPK Signaling Improves Axon Regeneration and Functional Recovery.J Neurosci | In animals | 2026 |
| [AMP-activated protein kinase activation alleviates lipopolysaccharide-induced sepsis-associated acute kidney injury by inhibiting ferroptosis].Zhonghua Wei Zhong Bing Ji Jiu Yi Xue | In animals | 2026 |
| Nicorandil ameliorates cardiac microcirculation in hypertensive myocardial infarction via LKB1/AMPK signaling activation.Pak J Pharm Sci | In animals | 2026 |
| Lactate-Induced Lipid Accumulation in Hepatocytes through GPR81 Activation.Diabetes Metab J | In animals | 2026 |
| Short-duration electrical pulse stimulation induces myokines and mitochondrial adaptations in C2C12 myotubes.J Muscle Res Cell Motil | In animals | 2026 |
| Electroacupuncture alleviates inflammatory pain through AMPK-autophagy signaling and suppression of iNOS and IL-1β in inflamed tissues.Mol Pain | In animals | 2026 |
| The AMPK-FOXO signaling regulates the transcriptional response of 4EBP to pesticide stress in Tribolium castaneum.Pestic Biochem Physiol | In animals | 2026 |
| AMPK regulates BK-channel current in CA1 hippocampal neurons.Biochim Biophys Acta Gen Subj | In animals | 2025 |
| AICAR Inhibits Insulin-Stimulated Glucose Uptake in 3T3-L1 Adipocytes via an AMPK-Independent, ZMP-Dependent Mechanism.Cells | In animals | 2025 |
| A novel long non-coding RNA, Lnc-GAS7, modulates myosin heavy chain isoform switching via AMPK signaling in ovine muscle.Int J Biol Macromol | In animals | 2025 |
| Cardiovascular and renal effects of 5-aminoimidazole-4-carboxyribonucleoside (AICAR) in the deoxycorticosterone acetate (DOCA)-salt rat model of hypertension.Life Sci | In animals | 2025 |
| Aerobic exercise ameliorates skeletal muscle atrophy in atic knockout zebrafish through the oxidative phosphorylation pathway.Free Radic Biol Med | In animals | 2025 |
| Nanoparticle-based methionine and AICAR delivery elicits a robust antitumor immune response.J Control Release | In animals | 2025 |
| Mechanisms of aerobic exercise on doxorubicin-induced cardiomyocyte apoptosis: based on AMPK/PI3K/AKT signalling pathway.Life Sci | In animals | 2025 |
| Reprogramming of Myeloid Responses to Volumetric Muscle Loss via Engineered Protein Nanoparticles.ACS Nano | In animals | 2025 |
| A comprehensive analysis of meat quality degradation and identification of spoilage markers in chicken during refrigerated storage using multi-method approach.Food Chem | In animals | 2025 |
| Classically activated macrophages undergo functionally significant nucleotide metabolism remodelling driven by nitric oxide.Nat Metab | In animals | 2025 |
| Downhill running induced mitophagy in rat soleus muscle via the AMPK pathway.J Physiol Biochem | In animals | 2025 |
| Decreased Expression and Secretion of the Myokine Fndc5/Irisin by Cisplatin Treatment in Mouse Skeletal Muscle.Calcif Tissue Int | In animals | 2025 |
| PTEN deficiency in postnatally developing Purkinje cells disrupts metabolic signaling, leading to dendritic abnormalities and sex-specific behavioral deficits.Sci Rep | In animals | 2025 |
| Muscle-specific AXIN1 and AXIN2 double knockout does not alter AMPK/mTORC1 signalling or glucose metabolism.J Physiol | In animals | 2025 |
| BDE-47 induces apoptosis and ferroptosis in Pseudosciaena crocea kidney (PCK) cells by disrupting mitochondrial energy metabolism.Aquat Toxicol | In animals | 2025 |
| Calcium dysregulation disrupts mitochondrial homeostasis by interfering AMPK/Drp1 pathway to aggravate plaque progression and instability.Theranostics | In animals | 2025 |
| miR-210 Regulates Autophagy Through the AMPK/mTOR Signaling Pathway, Reduces Neuronal Cell Death and Inflammatory Responses, and Enhances Functional Recovery Following Cerebral Hemorrhage in Mice.Neurochem Res | In animals | 2025 |
| Neuroprotective effect of small extracellular vesicle-mediated targeting of AMPKα2 in cerebral ischemia.Metabolism | In animals | 2025 |
| Bacterial purine metabolism modulates C. elegans development and stress tolerance via DAF-16.FEBS J | In animals | 2025 |
| HOPE and AMPK activation reduce reperfusion injury and metabolic dysfunction in primate steatotic liver grafts.Sci Rep | In animals | 2025 |
| Brain AMPK signaling improves intestinal barrier function through brain orexin and the vagal pathway in rats.Neurosci Lett | In animals | 2025 |
| Downregulation of NAD Kinase Expression in β-Cells Contributes to the Aging-Associated Decline in Glucose-Stimulated Insulin Secretion.Aging Cell | In animals | 2025 |
| Exercise-induced Sesn2 mediates autophagic flux to alleviate neural damage after ischemic stroke in mice.Exp Neurol | In animals | 2025 |
| AMPK agonist AICAR ameliorates maternal hepatic lipid metabolism disorder, inflammation, and fibrosis caused by PM2.5 exposure during pregnancy.Sci Rep | In animals | 2025 |
| Molecular Mechanism of Aerobic Exercise Ameliorating Myocardial Mitochondrial Injury in Mice with Heart Failure.Int J Mol Sci | In animals | 2025 |
| Bioenergetic adaptations of small intestinal epithelial cells reduce cell differentiation enhancing intestinal permeability in obese mice.Mol Metab | In animals | 2025 |
| Long-term glucosamine supplementation aggravates atrial fibrillation susceptibility by impairing AMPK signaling.Life Sci | In animals | 2025 |
| Potential Role of Aerobic Exercise in Attenuating Diabetic Cardiomyopathy via Modulation of P2X4-Mediated NLRP3 Inflammasome Activation and Pyroptosis.J Innate Immun | In animals | 2025 |
| AMPK activation mitigates inflammatory pain by modulating STAT3 phosphorylation in inflamed tissue macrophages of adult male mice.Mol Pain | In animals | 2025 |
| Activation of AMPK in platelets promotes the production of offspring.Platelets | In a lab dish | 2024 |
| Physiological levels of folic acid reveal purine alterations in Lesch-Nyhan disease.Proc Natl Acad Sci U S A | In a lab dish | 2020 |
| Five months of voluntary wheel running downregulates skeletal muscle LINE-1 gene expression in rats.Am J Physiol Cell Physiol | In a lab dish | 2019 |
| Acute activation of endothelial AMPK surprisingly inhibits endothelium-dependent hyperpolarization-like relaxations in rat mesenteric arteries.Br J Pharmacol | In a lab dish | 2019 |
| Mitochondrial ALDH2 protects against lipopolysaccharide-induced myocardial contractile dysfunction by suppression of ER stress and autophagy.Biochim Biophys Acta Mol Basis Dis | In a lab dish | 2019 |
| High Glucose Upregulated Vascular Smooth Muscle Endothelin Subtype B Receptors via Inhibition of Autophagy in Rat Superior Mesenteric Arteries.Ann Vasc Surg | In a lab dish | 2018 |
| Homocysteine up-regulates ETB receptors via suppression of autophagy in vascular smooth muscle cells.Microvasc Res | In a lab dish | 2018 |
| Prior treatment with the AMPK activator AICAR induces subsequently enhanced glucose uptake in isolated skeletal muscles from 24-month-old rats.Appl Physiol Nutr Metab | In a lab dish | 2018 |
| AMP-activated protein kinase and adenosine are both metabolic modulators that regulate chloride secretion in the shark rectal gland ( Squalus acanthias).Am J Physiol Cell Physiol | In a lab dish | 2018 |
| Linkage of Metabolic Defects to Activated PIK3CA Alleles in Endothelial Cells Derived from Lymphatic Malformation.Lymphat Res Biol | In a lab dish | 2018 |
| Studying the Role of AMPK in Cardiac Hypertrophy and Protein Synthesis.Methods Mol Biol | In a lab dish | 2018 |
| Regulatory effects of the AMPKα-SIRT1 molecular pathway on insulin resistance in PCOS mice: An in vitro and in vivo study.Biochem Biophys Res Commun | In a lab dish | 2017 |
| Treatment with AICAR inhibits blastocyst development, trophectoderm differentiation and tight junction formation and function in mice.Mol Hum Reprod | In a lab dish | 2017 |
| In vitro progesterone production by luteinized human mural granulosa cells is modulated by activation of AMPK and cause of infertility.Reprod Biol Endocrinol | In a lab dish | 2017 |
| 5-Aminoimidazole-4-carboxamide 1-β-D-ribofuranoside reduces intimal hyperplasia of tissue engineering blood vessel by inhibiting phenotype switch of vascular smooth muscle cell.J Biomed Mater Res B Appl Biomater | In a lab dish | 2017 |
| GFAT1 phosphorylation by AMPK promotes VEGF-induced angiogenesis.Biochem J | In a lab dish | 2017 |
| Enhanced Muscle Insulin Sensitivity After Contraction/Exercise Is Mediated by AMPK.Diabetes | In a lab dish | 2017 |
| Benzimidazole derivative small-molecule 991 enhances AMPK activity and glucose uptake induced by AICAR or contraction in skeletal muscle.Am J Physiol Endocrinol Metab | In a lab dish | 2016 |
| Involvement of exogenous H2S in recovery of cardioprotection from ischemic post-conditioning via increase of autophagy in the aged hearts.Int J Cardiol | In a lab dish | 2016 |
| Cardiotrophin-1 decreases intestinal sugar uptake in mice and in Caco-2 cells.Acta Physiol (Oxf) | In a lab dish | 2016 |
| Activation of AMPK improves inflammation and insulin resistance in adipose tissue and skeletal muscle from pregnant women.J Physiol Biochem | In a lab dish | 2015 |
| AMPK Activation Affects Glutamate Metabolism in Astrocytes.Neurochem Res | In a lab dish | 2015 |
| Analysis of aquaporin expression in liver with a focus on hepatocytes.Histochem Cell Biol | In a lab dish | 2015 |
| Maintaining Moderate Platelet Aggregation and Improving Metabolism of Endothelial Progenitor Cells Increase the Patency Rate of Tissue-Engineered Blood Vessels.Tissue Eng Part A | In a lab dish | 2015 |
| AMP-activated protein kinase (AMPK) activation inhibits nuclear translocation of Smad4 in mesangial cells and diabetic kidneys.Am J Physiol Renal Physiol | In a lab dish | 2015 |
| Activation of AMPK in human fetal membranes alleviates infection-induced expression of pro-inflammatory and pro-labour mediators.Placenta | In a lab dish | 2015 |
| Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity.J Hepatol | In a lab dish | 2014 |
| Regulatory effect of AMP-activated protein kinase on pulmonary hypertension induced by chronic hypoxia in rats: in vivo and in vitro studies.Mol Biol Rep | In a lab dish | 2014 |
| The effect of small molecules on nuclear-encoded translation diseases.Biochimie | In a lab dish | 2014 |
| Adiponectin regulates ACTH secretion and the HPAA in an AMPK-dependent manner in pituitary corticotroph cells.Mol Cell Endocrinol | In a lab dish | 2014 |
| AICAR-induced energy supply and paracrine activity of endothelial cells accelerate chronic diabetic wound healing by promoting angiogenesis and modulating macrophage reprogramming.Mater Today Bio | Other paper | 2026 |
| Investigation of exercise-mimetic bioactive molecules as modulators of MMP activity and expression in cancer cells.J Enzyme Inhib Med Chem | Other paper | 2026 |
| Swimming exercise protects against diabetic cardiomyopathy through suppression of FABP4-associated CTRP3 degradation.Cell Signal | Other paper | 2026 |
| NUAK isoforms promote glucose and glutamine metabolic reprogramming driven colon cancer progression and migration through regulation of AMPK/mTOR signaling.J Mol Med (Berl) | Other paper | 2026 |
| Quantitative Analysis Reveals IL-17A Widens Nasal Epithelial Tight Junction Gaps via AMPK in Allergic Rhinitis.Ann Allergy Asthma Immunol | Other paper | 2026 |
| AMPK activation stabilizes HIF-2α by disrupting VHL binding and promotes erythroid differentiation under anemic stress via the mTOR pathway.Front Physiol | Other paper | 2026 |
| PKP2 orchestrates OXPHOS expression in cardiomyocytes via a PGC1α-dependent mechanism.Cardiovasc Res | Other paper | 2026 |
| Impaired fatty acid oxidation and mitochondrial injury mediated by the AMPK/PPARα pathway: A key mechanism in high-fat diet-aggravated ulcerative colitis.PLoS One | Other paper | 2026 |
| Caffeic acid phenethyl ester inhibits adipogenic differentiation in association with INSR suppression and AMPK activation.Biochim Biophys Acta Gene Regul Mech | Other paper | 2026 |
| Simvastatin enhances the antitumor activity of temsirolimus through AMPK-associated metabolic modulation in clear-cell renal cell carcinoma.Naunyn Schmiedebergs Arch Pharmacol | Other paper | 2026 |
| Salvianolic Acid A Inhibits Ferroptosis in Endothelial Cells and the Progression of Atherosclerosis by Augmenting the Mitochondrial Homeostasis Pathway Associated With Adiponectin Receptor 1.Phytother Res | Other paper | 2026 |
| AFF4 Loss Compromises Osteogenesis of Orofacial Mesenchymal Stem Cells During Alveolar Bone Repair via AMPK-Mediated Mitophagy.Cell Prolif | Other paper | 2026 |
| Developmental Environmental Chronotoxicity by Polystyrene Nanoplastics Exacerbates High-Fat Diet-Induced Pediatric MAFLD Through Circadian Disruption and Mitochondrial Dysfunction.Adv Sci (Weinh) | Other paper | 2026 |
| Metabolic reprogramming of decidual macrophages impairs maternal-fetal interface homeostasis and contributes to recurrent spontaneous abortion.Biochem Pharmacol | Other paper | 2026 |
| Hepassocin prevents age-related liver senescence and facilitates liver regeneration by activating AMPK.Signal Transduct Target Ther | Other paper | 2026 |
| Holistic Regulation of Body-Mind Acupuncture Activates Leptin Receptor-AMPK Signaling to Restore Mitochondrial Homeostasis in Chronic Fatigue Syndrome in vitro and in vivo.Chin J Integr Med | Other paper | 2026 |
| Thapsigargin-induced autophagic flux impairment and inflammation are potentiated by CLN3 deficiency and alleviated by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in human ARPE-19 cells.Biochem Biophys Res Commun | Other paper | 2026 |
| Sub-chronic exposure to lanthanum chloride induces hepatic steatosis via AMPK-dependent lipophagic defects in male zebrafish.Ecotoxicol Environ Saf | Other paper | 2026 |
| AMPK activation by AICAR mitigates hypoxic corneal damage through rebuilding energy and metabolic homeostasis.Chem Biol Interact | Other paper | 2026 |
| N-nitrosodimethylamine increased glucose production by promoting hyperglycemia in hepatocyte via AMPK signaling pathway in vivo and in vitro.Drug Chem Toxicol | Other paper | 2026 |
| Obesity-related palmitic acid exacerbates IL-13-induced mucus phenotype in 16HBE airway epithelial cells via AMPK suppression.Transl Pediatr | Other paper | 2026 |
| Berberine Regulates Hepatic Fatty Acid Metabolism via AMPK/SIRT1/PGC-1α Pathway.Chin J Integr Med | Other paper | 2026 |
| Purine-Metabolism Reprogramming Associated with Failed-Repair Proximal Tubule States in the AKI-to-CKD Transition.Metabolites | Other paper | 2026 |
| Pharmacological inhibition of TRPM4 channel stabilizes atherosclerotic plaque via inhibiting AMPK-Beclin1-mediated autophagy.Eur J Pharmacol | Other paper | 2026 |
| AMPK-driven immunometabolic reprogramming enhances CD19+CD21hiCD24hi regulatory B-cell-mediated suppression of atopic dermatitis.J Allergy Clin Immunol | Other paper | 2026 |
| [Costunolide improves sorafenib-induced cardiomyocyte injury by inhibiting mitophagy].Zhongguo Zhong Yao Za Zhi | Other paper | 2026 |
| AMPK orchestrates mitochondrial homeostasis via dynamics and mitophagy to combat hypoxia-induced energetic crisis in keratocytes.Cell Biol Toxicol | Other paper | 2026 |
| Exogenous pyruvate restores mitochondrial bioenergetics by synergizing with the AMPK-mTOR-SIRT3 pathway to alleviate sepsis-associated acute kidney injury.Chem Biol Interact | Other paper | 2026 |
| 5-Aminoimidazole-4-carboxamide riboside, an AMPK activator, enhances TRAIL-mediated apoptosis in human bladder cancer cells in a p38 MAPK-dependent manner.Genes Genomics | Other paper | 2026 |
| Impaired AMP-Dependent Protein Kinase-Mediated Neutrophil Extracellular Trap Clearance by Aged Macrophages in Sepsis-Induced Liver Injury.Anesth Analg | Other paper | 2026 |
| Serum Starvation Promotes the Proteolysis of OGT by Activating AMPK and the CUL1/SKP1/SKP2 E3 Ubiquitin Ligase in 3T3-L1 Cells.Biomol Ther (Seoul) | Other paper | 2026 |
| Developmental lead (pb) exposure induces anxiety and depression-like behaviors via inhibiting the AMPK/ACSS2 pathway.Curr Res Toxicol | Other paper | 2026 |
| Plasma proteomics stratification identifies phospholamban R14del carriers at risk for disease progression.Cardiovasc Res | Other paper | 2026 |
| Spatially resolved in vivo ratiometric imaging of mitochondrial quality control using co-registered confocal-OCT.Biomed Opt Express | Other paper | 2026 |
| RAB5A regulates cell proliferation and lipid metabolism by modulating mitochondrial ROS via AMPK signaling pathway in ovarian granulosa cells.Redox Biol | Other paper | 2026 |
| Metformin inhibits PDGFβ signaling to suppress hyaluronan and cytokine production in thyroid eye disease.Exp Eye Res | Other paper | 2026 |
| The role of NPY in liver transplantation from extended-criteria donors.Free Radic Biol Med | Other paper | 2026 |
| AMPK promotes TFEB transcriptional activity through dephosphorylation at both MTORC1-dependent and -independent sites.Autophagy | Other paper | 2026 |
| 5-Aminoimidazole-4-carboxamide-1- β ${\bf {\beta}}$ -d-ribofuranoside ameliorates lipotoxicity through enhanced reticulophagy in HepG2 cells.Biotechnol Appl Biochem | Other paper | 2026 |
| Neuroprotective effects of Platycladus orientalis ethyl acetate fraction on retinal Müller cells: modulation of AKT1/mTOR and Raf-1/MEK1/2 pathways via AMPK activation.Front Mol Biosci | Other paper | 2026 |
| Protective effects of adiponectin receptor agonists against equine lamellar endoplasmic reticulum stress.Equine Vet J | Other paper | 2026 |
| AMPK-p38 axis converts human pluripotent stem cells to naive state.iScience | Other paper | 2026 |
| Purine Metabolism Regulates the Severity of APOL1 Nephropathy.J Am Soc Nephrol | Other paper | 2026 |
| Roles of RRM2 and RRM2B in pyrimidine stress responses and differentiation of acute myeloid leukemia cells.Cell Death Discov | Other paper | 2026 |
| Rapid Analysis of Urinary AICAR by Liquid Chromatography-Isotope Ratio Mass Spectrometry.Anal Chem | Other paper | 2026 |
| TRIM24 Regulates Adaptation to Glucose Deprivation in Association with Aspartate Accumulation and Impaired AMPK Signaling.Curr Issues Mol Biol | Other paper | 2026 |
| The AMPK activator A769662 promotes ferroptosis and suppresses disulfidptosis by inhibiting SLC7A11.Biochem Biophys Res Commun | Other paper | 2026 |
| Elevated Kallistatin Induces Myosteatosis and Exercise Intolerance by Antagonizing AdipoR1-Mediated AMPK Signalling.J Cachexia Sarcopenia Muscle | Other paper | 2026 |
| MFN2 interacts with phosphorylated AMPK to mediate mitophagy in MCF-7 cells.Int J Biochem Cell Biol | Other paper | 2026 |
| Mechanistic study of miR-148a-3p-mediated AMPK/mTOR/S6-dependent autophagy in hepatitis B virus replication.Virus Genes | Other paper | 2026 |
| Organophosphate pesticide DEDT promotes diabetic retinopathy progression via AMPK/Nrf2/HO-1 pathway.Sci Rep | Other paper | 2026 |
| The role of autophagy in microwave radiation induced toxicity in iPSC-derived cardiomyocytes.Curr Res Toxicol | Other paper | 2026 |
| The fungistatic mechanism of benzaldehyde against the nematophagous fungus Arthrobotrys oligospora suggests a method for manipulating soil fungistasis.Commun Biol | Other paper | 2026 |
| A novel Chinese medicine formula against hyperuricemia-induced kidney inflammation involving pyroptosis inhibition via modulating AMPK-TLR4-NLRP3 pathway.Chin Med | Other paper | 2026 |
| Defective autophagy and AMPK inactivation drive ferroptosis in diabetic kidney disease.Diabetologia | Other paper | 2026 |
| Ex vivo lung perfusion enhances donor lung preservation in mice via Hippo signaling activation.Am J Respir Cell Mol Biol | Other paper | 2026 |
| FNDC5/Irisin-dependent renoprotection of resistance training in myocardial infarction-induced Type 2 cardiorenal syndrome.PLoS One | Other paper | 2026 |
| Regulation of ovarian maturation in Macrobrachium nipponense by the ribonucleotide reductase M1 subunit.Mar Life Sci Technol | Other paper | 2026 |
| Vitamin A-activated PPARγ signaling enhances intramuscular fat accumulation by overriding AMPK-mediated inhibition in late-fattening beef cattle.J Anim Sci Biotechnol | Other paper | 2026 |
| AICAR attenuates ischemia-reperfusion-induced AKI by modulating AMPK-TXNIP-NLRP3 pathway and energy metabolism.Cell Mol Life Sci | Other paper | 2026 |