# 5-amino-1MQ 5-amino-1-methylquinolinium · NNMT inhibitor https://graded.pl/en/substances/5-amino-1mq · Checked: Not yet Preliminary version. The editors have not finished checking this card, and grades may change. A small molecule, not a peptide, that blocks an enzyme called NNMT. In mice, mostly from one research group, it reduced weight and fat. No study in people has been published and none is registered. > This site is for information and education only. It does not promote or encourage the use or purchase of the substances described and is not medical advice. Many are not authorised as medicines and their safety has not been established. We sell nothing and have no ties to sellers. For health decisions, consult a doctor. ## Short answers ### Does 5-amino-1MQ work? A small molecule, not a peptide, that blocks an enzyme called NNMT. In mice, mostly from one research group, it reduced weight and fat. No study in people has been published and none is registered. Strength: grade D, not clear. Only studies in old mice, from one research group. Their grip strength was about 40% higher than in untreated mice, and an injured leg muscle recovered more force. No study in people exists. Fat loss: grade D, not clear. Only mouse studies: four papers, all from one research group. Obese mice on a high-fat diet lost weight and fat, and in the first study food intake did not change. No study in people has been published or registered, and the mice were given injections, not capsules. ### Is 5-amino-1MQ legal? PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). US: No approval. The FDA drug register has no such medicine. ### Is 5-amino-1MQ banned in sport? May be banned, WADA 2026. It is not on the WADA list, but WADA also bans substances that no health authority has approved, so it may be banned. ### Is 5-amino-1MQ safe? Not known. Studied in mice, which showed no visible harm. No study in people exists, and a 2026 review lists the unknown safety profile as an open problem. ## What studies show | | | | | |---|---|---|---| | Strength | D | Not clear | Only studies in old mice, from one research group. Their grip strength was about 40% higher than in untreated mice, and an injured leg muscle recovered more force. No study in people exists. | | Fat loss | D | Not clear | Only mouse studies: four papers, all from one research group. Obese mice on a high-fat diet lost weight and fat, and in the first study food intake did not change. No study in people has been published or registered, and the mice were given injections, not capsules. | ## Studies we have read - Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice. (Scientific reports 2024; In animals, n=35) https://pubmed.ncbi.nlm.nih.gov/38969654/ - Nicotinamide N-methyltransferase inhibition mitigates obesity-related metabolic dysfunction. (Diabetes, obesity & metabolism 2024; In animals, n=24) https://pubmed.ncbi.nlm.nih.gov/39161060/ - Reduced calorie diet combined with NNMT inhibition establishes a distinct microbiome in DIO mice. (Scientific reports 2022; In animals) https://pubmed.ncbi.nlm.nih.gov/35013352/ - Combined nicotinamide N-methyltransferase inhibition and reduced-calorie diet normalizes body composition and enhances metabolic benefits in obese mice. (Scientific reports 2021; In animals) https://pubmed.ncbi.nlm.nih.gov/33707534/ - Small molecule nicotinamide N-methyltransferase inhibitor activates senescent muscle stem cells and improves regenerative capacity of aged skeletal muscle. (Biochemical pharmacology 2019; In animals, n=48) https://pubmed.ncbi.nlm.nih.gov/30753815/ - Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice. (Biochemical pharmacology 2018; In animals, n=18) https://pubmed.ncbi.nlm.nih.gov/29155147/ ## Is it legal - PL: No approval. The European medicines database (EMA) lists no such medicine in Poland (9 October 2026). The Polish register was down, so we could not check it directly. https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet) - EU: No approval. The European medicines database (EMA), which covers EU and national approvals, lists no such medicine (9 October 2026). https://www.ema.europa.eu/en/documents/other/article-57-product-data_en.xlsx (Checked: Not yet) - US: No approval. The FDA drug register has no such medicine. https://www.accessdata.fda.gov/scripts/cder/daf/ (Checked: Not yet) ## Doping May be banned, WADA 2026. https://zoek.officielebekendmakingen.nl/trb-2026-25.html ## How much research exists - Scientific papers: 3 - Studies with random groups: 0 - Registered studies in people: 0 - These are search results. A count shows how much exists, not how good the studies are. 1 Nov 2026. --- Open data: CC BY 4.0, https://creativecommons.org/licenses/by/4.0/